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A combination of pl...
A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes The EPIC-InterAct case-cohort study
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Imamura, Fumiaki (författare)
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Sharp, Stephen J. (författare)
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Koulman, Albert (författare)
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visa fler...
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Schulze, Matthias B. (författare)
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Kröger, Janine (författare)
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Griffin, Julian L. (författare)
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Huerta, José M. (författare)
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Guevara, Marcela (författare)
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Sluijs, Ivonne (författare)
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Agudo, Antonio (författare)
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Ardanaz, Eva (författare)
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Balkau, Beverley (författare)
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Boeing, Heiner (författare)
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Chajes, Veronique (författare)
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Dahm, Christina C. (författare)
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Dow, Courtney (författare)
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Fagherazzi, Guy (författare)
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Feskens, Edith J. M. (författare)
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Franks, Paul W. (författare)
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Gavrila, Diana (författare)
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Gunter, Marc (författare)
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Kaaks, Rudolf (författare)
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Key, Timothy J. (författare)
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Khaw, Kay-Tee (författare)
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Kuehn, Tilman (författare)
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Melander, Olle (författare)
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Molina-Portillo, Elena (författare)
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Nilsson, Peter M. (författare)
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Olsen, Anja (författare)
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Overvad, Kim (författare)
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Palli, Domenico (författare)
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Panico, Salvatore (författare)
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Rolandsson, Olov (författare)
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Sieri, Sabina (författare)
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Sacerdote, Carlotta (författare)
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Slimani, Nadia (författare)
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Spijkerman, Annemieke M. W. (författare)
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Tjønneland, Anne (författare)
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Tumino, Rosario (författare)
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van der Schouw, Yvonne T. (författare)
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Langenberg, Claudia (författare)
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Riboli, Elio (författare)
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Forouhi, Nita G. (författare)
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Wareham, Nick J. (författare)
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visa färre...
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(utgivare)
- Public Library Science 2017
- 2017
- Engelska.
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Ingår i: PLoS Medicine. - 1549-1277. ; 14:10
Abstract
Ämnesord
Stäng
- Background Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated. Methods and findings We measured plasma phospholipid fatty acids by gas chromatography in 27,296 adults, including 12,132 incident cases of T2D, over the follow-up period between baseline (1991-1998) and 31 December 2007 in 8 European countries in EPIC-InterAct, a nested casecohort study. The first principal component derived by principal component analysis of 27 individual fatty acids (mole percentage) was the main exposure (subsequently called the fatty acid pattern score [FA-pattern score]). The FA-pattern score was partly characterised by high concentrations of linoleic acid, stearic acid, odd-chain fatty acids, and very-long-chain saturated fatty acids and low concentrations of.-linolenic acid, palmitic acid, and long-chain monounsaturated fatty acids, and it explained 16.1% of the overall variability of the 27 fatty acids. Based on country-specific Prentice-weighted Cox regression and random-effects meta-analysis, the FA-pattern score was associated with lower incident T2D. Comparing the top to the bottom fifth of the score, the hazard ratio of incident T2D was 0.23 (95% CI 0.19-0.29) adjusted for potential confounders and 0.37 (95% CI 0.27-0.50) further adjusted for metabolic risk factors. The association changed little after adjustment for individual fatty acids or fatty acid subclasses. In cross-sectional analyses relating the FA-pattern score to metabolic, genetic, and dietary factors, the FA-pattern score was inversely associated with adiposity, triglycerides, liver enzymes, C-reactive protein, a genetic score representing insulin resistance, and dietary intakes of soft drinks and alcohol and was positively associated with high-density-lipoprotein cholesterol and intakes of polyunsaturated fat, dietary fibre, and coffee (p < 0.05 each). Limitations include potential measurement error in the fatty acids and other model covariates and possible residual confounding. Conclusions A combination of individual fatty acids, characterised by high concentrations of linoleic acid, odd-chain fatty acids, and very long-chain fatty acids, was associated with lower incidence of T2D. The specific fatty acid pattern may be influenced by metabolic, genetic, and dietary factors.
Ämnesord
- Medical and Health Sciences (hsv)
- Health Sciences (hsv)
- Nutrition and Dietetics (hsv)
- Medicin och hälsovetenskap (hsv)
- Hälsovetenskaper (hsv)
- Näringslära (hsv)
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- Av författaren/redakt...
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Imamura, Fumiaki
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Sharp, Stephen J ...
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Koulman, Albert
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Schulze, Matthia ...
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Kröger, Janine
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Griffin, Julian ...
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visa fler...
-
Huerta, José M.
-
Guevara, Marcela
-
Sluijs, Ivonne
-
Agudo, Antonio
-
Ardanaz, Eva
-
Balkau, Beverley
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Boeing, Heiner
-
Chajes, Veroniqu ...
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Dahm, Christina ...
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Dow, Courtney
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Fagherazzi, Guy
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Feskens, Edith J ...
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Franks, Paul W.
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Gavrila, Diana
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Gunter, Marc
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Kaaks, Rudolf
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Key, Timothy J.
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Khaw, Kay-Tee
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Kuehn, Tilman
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Melander, Olle
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Molina-Portillo, ...
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Nilsson, Peter M ...
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Olsen, Anja
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Overvad, Kim
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Palli, Domenico
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Panico, Salvator ...
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Rolandsson, Olov
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Sieri, Sabina
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Sacerdote, Carlo ...
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Slimani, Nadia
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Spijkerman, Anne ...
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Tjønneland, Anne
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Tumino, Rosario
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van der Schouw, ...
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Langenberg, Clau ...
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Riboli, Elio
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Forouhi, Nita G.
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Wareham, Nick J.
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