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Argonaute2 Mediates...
Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell.
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Tattikota, Sudhir G (author)
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Rathjen, Thomas (author)
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McAnulty, Sarah J (author)
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Wessels, Hans-Hermann (author)
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Akerman, Ildem (author)
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van de Bunt, Martijn (author)
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Hausser, Jean (author)
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- Esguerra, Jonathan (author)
- Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups
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Musahl, Anne (author)
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Pandey, Amit K (author)
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You, Xintian (author)
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Chen, Wei (author)
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Herrera, Pedro L (author)
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Johnson, Paul R (author)
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O'Carroll, Donal (author)
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- Eliasson, Lena (author)
- Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups
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Zavolan, Mihaela (author)
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Gloyn, Anna L (author)
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Ferrer, Jorge (author)
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Shalom-Feuerstein, Ruby (author)
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Aberdam, Daniel (author)
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Poy, Matthew N (author)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Cell Metabolism. - : Elsevier BV. - 1550-4131. ; 19:1, s. 122-134
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https://doi.org/10.1...
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Abstract
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- Pancreatic β cells adapt to compensate for increased metabolic demand during insulin resistance. Although the microRNA pathway has an essential role in β cell proliferation, the extent of its contribution is unclear. Here, we report that miR-184 is silenced in the pancreatic islets of insulin-resistant mouse models and type 2 diabetic human subjects. Reduction of miR-184 promotes the expression of its target Argonaute2 (Ago2), a component of the microRNA-induced silencing complex. Moreover, restoration of miR-184 in leptin-deficient ob/ob mice decreased Ago2 and prevented compensatory β cell expansion. Loss of Ago2 during insulin resistance blocked β cell growth and relieved the regulation of miR-375-targeted genes, including the growth suppressor Cadm1. Lastly, administration of a ketogenic diet to ob/ob mice rescued insulin sensitivity and miR-184 expression and restored Ago2 and β cell mass. This study identifies the targeting of Ago2 by miR-184 as an essential component of the compensatory response to regulate proliferation according to insulin sensitivity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tattikota, Sudhi ...
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Rathjen, Thomas
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McAnulty, Sarah ...
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Wessels, Hans-He ...
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Akerman, Ildem
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van de Bunt, Mar ...
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show more...
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Hausser, Jean
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Esguerra, Jonath ...
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Musahl, Anne
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Pandey, Amit K
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You, Xintian
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Chen, Wei
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Herrera, Pedro L
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Johnson, Paul R
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O'Carroll, Donal
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Eliasson, Lena
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Zavolan, Mihaela
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Gloyn, Anna L
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Ferrer, Jorge
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Shalom-Feuerstei ...
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Aberdam, Daniel
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Poy, Matthew N
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell Metabolism
- By the university
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Lund University