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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Elks, Cathy E (author)
Perry, John R B (author)
Sulem, Patrick (author)
show more...
Chasman, Daniel I (author)
Franceschini, Nora (author)
He, Chunyan (author)
Lunetta, Kathryn L (author)
Visser, Jenny A (author)
Byrne, Enda M (author)
Cousminer, Diana L (author)
Gudbjartsson, Daniel F (author)
Esko, Tõnu (author)
Feenstra, Bjarke (author)
Hottenga, Jouke-Jan (author)
Koller, Daniel L (author)
Kutalik, Zoltán (author)
Lin, Peng (author)
Mangino, Massimo (author)
Marongiu, Mara (author)
McArdle, Patrick F (author)
Smith, Albert V (author)
Stolk, Lisette (author)
van Wingerden, Sophie H (author)
Zhao, Jing Hua (author)
Albrecht, Eva (author)
Corre, Tanguy (author)
Ingelsson, Erik, 1975- (author)
Karolinska Institutet
Hayward, Caroline (author)
Magnusson, Patrik K E (author)
Karolinska Institutet
Smith, Erin N (author)
Ulivi, Shelia (author)
Warrington, Nicole M (author)
Zgaga, Lina (author)
Alavere, Helen (author)
Amin, Najaf (author)
Aspelund, Thor (author)
Bandinelli, Stefania (author)
Barroso, Inês (author)
Berenson, Gerald S (author)
Bergmann, Sven (author)
Blackburn, Hannah (author)
Boerwinkle, Eric (author)
Buring, Julie E (author)
Busonero, Fabio (author)
Campbell, Harry (author)
Chanock, Stephen J (author)
Chen, Wei (author)
Cornelis, Marilyn C (author)
Couper, David (author)
Coviello, Andrea D (author)
d'Adamo, Pio (author)
de Faire, Ulf (author)
Karolinska Institutet
de Geus, Eco J C (author)
Deloukas, Panos (author)
Döring, Angela (author)
Smith, George Davey (author)
Easton, Douglas F (author)
Eiriksdottir, Gudny (author)
Emilsson, Valur (author)
Eriksson, Johan (author)
Ferrucci, Luigi (author)
Folsom, Aaron R (author)
Foroud, Tatiana (author)
Garcia, Melissa (author)
Gasparini, Paolo (author)
Geller, Frank (author)
Gieger, Christian (author)
Gudnason, Vilmundur (author)
Hall, Per (author)
Karolinska Institutet
Hankinson, Susan E (author)
Ferreli, Liana (author)
Heath, Andrew C (author)
Hernandez, Dena G (author)
Hofman, Albert (author)
Hu, Frank B (author)
Illig, Thomas (author)
Järvelin, Marjo-Riitta (author)
Johnson, Andrew D (author)
Karasik, David (author)
Khaw, Kay-Tee (author)
Kiel, Douglas P (author)
Kilpeläinen, Tuomas O (author)
Kolcic, Ivana (author)
Kraft, Peter (author)
Launer, Lenore J (author)
Laven, Joop S E (author)
Li, Shengxu (author)
Liu, Jianjun (author)
Levy, Daniel (author)
Martin, Nicholas G (author)
McArdle, Wendy L (author)
Melbye, Mads (author)
Mooser, Vincent (author)
Murray, Jeffrey C (author)
Murray, Sarah S (author)
Nalls, Michael A (author)
Navarro, Pau (author)
Nelis, Mari (author)
Ness, Andrew R (author)
Northstone, Kate (author)
Oostra, Ben A (author)
Peacock, Munro (author)
Palmer, Lyle J (author)
Palotie, Aarno (author)
Paré, Guillaume (author)
Parker, Alex N (author)
Pedersen, Nancy L (author)
Karolinska Institutet
Peltonen, Leena (author)
Pennell, Craig E (author)
Pharoah, Paul (author)
Polasek, Ozren (author)
Plump, Andrew S (author)
Pouta, Anneli (author)
Porcu, Eleonora (author)
Rafnar, Thorunn (author)
Rice, John P (author)
Ring, Susan M (author)
Rivadeneira, Fernando (author)
Rudan, Igor (author)
Sala, Cinzia (author)
Salomaa, Veikko (author)
Sanna, Serena (author)
Schlessinger, David (author)
Schork, Nicholas J (author)
Scuteri, Angelo (author)
Segrè, Ayellet V (author)
Shuldiner, Alan R (author)
Soranzo, Nicole (author)
Sovio, Ulla (author)
Srinivasan, Sathanur R (author)
Strachan, David P (author)
Tammesoo, Mar-Liis (author)
Tikkanen, Emmi (author)
Toniolo, Daniela (author)
Tsui, Kim (author)
Tryggvadottir, Laufey (author)
Tyrer, Jonathon (author)
Uda, Manuela (author)
van Dam, Rob M (author)
van Meurs, Joyce B J (author)
Vollenweider, Peter (author)
Waeber, Gerard (author)
Wareham, Nicholas J (author)
Waterworth, Dawn M (author)
Weedon, Michael N (author)
Wichmann, H Erich (author)
Willemsen, Gonneke (author)
Wilson, James F (author)
Wright, Alan F (author)
Young, Lauren (author)
Zhai, Guangju (author)
Zhuang, Wei Vivian (author)
Bierut, Laura J (author)
Boomsma, Dorret I (author)
Boyd, Heather A (author)
Crisponi, Laura (author)
Demerath, Ellen W (author)
van Duijn, Cornelia M (author)
Econs, Michael J (author)
Harris, Tamara B (author)
Hunter, David J (author)
Loos, Ruth J F (author)
Metspalu, Andres (author)
Montgomery, Grant W (author)
Ridker, Paul M (author)
Spector, Tim D (author)
Streeten, Elizabeth A (author)
Stefansson, Kari (author)
Thorsteinsdottir, Unnur (author)
Uitterlinden, André G (author)
Widen, Elisabeth (author)
Murabito, Joanne M (author)
Ong, Ken K (author)
Murray, Anna (author)
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 (creator_code:org_t)
2010-11-21
2010
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:12, s. 1077-85
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

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By the author/editor
Elks, Cathy E
Perry, John R B
Sulem, Patrick
Chasman, Daniel ...
Franceschini, No ...
He, Chunyan
show more...
Lunetta, Kathryn ...
Visser, Jenny A
Byrne, Enda M
Cousminer, Diana ...
Gudbjartsson, Da ...
Esko, Tõnu
Feenstra, Bjarke
Hottenga, Jouke- ...
Koller, Daniel L
Kutalik, Zoltán
Lin, Peng
Mangino, Massimo
Marongiu, Mara
McArdle, Patrick ...
Smith, Albert V
Stolk, Lisette
van Wingerden, S ...
Zhao, Jing Hua
Albrecht, Eva
Corre, Tanguy
Ingelsson, Erik, ...
Hayward, Carolin ...
Magnusson, Patri ...
Smith, Erin N
Ulivi, Shelia
Warrington, Nico ...
Zgaga, Lina
Alavere, Helen
Amin, Najaf
Aspelund, Thor
Bandinelli, Stef ...
Barroso, Inês
Berenson, Gerald ...
Bergmann, Sven
Blackburn, Hanna ...
Boerwinkle, Eric
Buring, Julie E
Busonero, Fabio
Campbell, Harry
Chanock, Stephen ...
Chen, Wei
Cornelis, Marily ...
Couper, David
Coviello, Andrea ...
d'Adamo, Pio
de Faire, Ulf
de Geus, Eco J C
Deloukas, Panos
Döring, Angela
Smith, George Da ...
Easton, Douglas ...
Eiriksdottir, Gu ...
Emilsson, Valur
Eriksson, Johan
Ferrucci, Luigi
Folsom, Aaron R
Foroud, Tatiana
Garcia, Melissa
Gasparini, Paolo
Geller, Frank
Gieger, Christia ...
Gudnason, Vilmun ...
Hall, Per
Hankinson, Susan ...
Ferreli, Liana
Heath, Andrew C
Hernandez, Dena ...
Hofman, Albert
Hu, Frank B
Illig, Thomas
Järvelin, Marjo- ...
Johnson, Andrew ...
Karasik, David
Khaw, Kay-Tee
Kiel, Douglas P
Kilpeläinen, Tuo ...
Kolcic, Ivana
Kraft, Peter
Launer, Lenore J
Laven, Joop S E
Li, Shengxu
Liu, Jianjun
Levy, Daniel
Martin, Nicholas ...
McArdle, Wendy L
Melbye, Mads
Mooser, Vincent
Murray, Jeffrey ...
Murray, Sarah S
Nalls, Michael A
Navarro, Pau
Nelis, Mari
Ness, Andrew R
Northstone, Kate
Oostra, Ben A
Peacock, Munro
Palmer, Lyle J
Palotie, Aarno
Paré, Guillaume
Parker, Alex N
Pedersen, Nancy ...
Peltonen, Leena
Pennell, Craig E
Pharoah, Paul
Polasek, Ozren
Plump, Andrew S
Pouta, Anneli
Porcu, Eleonora
Rafnar, Thorunn
Rice, John P
Ring, Susan M
Rivadeneira, Fer ...
Rudan, Igor
Sala, Cinzia
Salomaa, Veikko
Sanna, Serena
Schlessinger, Da ...
Schork, Nicholas ...
Scuteri, Angelo
Segrè, Ayellet V
Shuldiner, Alan ...
Soranzo, Nicole
Sovio, Ulla
Srinivasan, Sath ...
Strachan, David ...
Tammesoo, Mar-Li ...
Tikkanen, Emmi
Toniolo, Daniela
Tsui, Kim
Tryggvadottir, L ...
Tyrer, Jonathon
Uda, Manuela
van Dam, Rob M
van Meurs, Joyce ...
Vollenweider, Pe ...
Waeber, Gerard
Wareham, Nichola ...
Waterworth, Dawn ...
Weedon, Michael ...
Wichmann, H Eric ...
Willemsen, Gonne ...
Wilson, James F
Wright, Alan F
Young, Lauren
Zhai, Guangju
Zhuang, Wei Vivi ...
Bierut, Laura J
Boomsma, Dorret ...
Boyd, Heather A
Crisponi, Laura
Demerath, Ellen ...
van Duijn, Corne ...
Econs, Michael J
Harris, Tamara B
Hunter, David J
Loos, Ruth J F
Metspalu, Andres
Montgomery, Gran ...
Ridker, Paul M
Spector, Tim D
Streeten, Elizab ...
Stefansson, Kari
Thorsteinsdottir ...
Uitterlinden, An ...
Widen, Elisabeth
Murabito, Joanne ...
Ong, Ken K
Murray, Anna
show less...
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Nature Genetics
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Uppsala University
Karolinska Institutet

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