| 41. |
- Rauramaa, Tuomas, et al.
(författare)
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Consensus Recommendations on Pathologic Changes in the Hippocampus : A Postmortem Multicenter Inter-Rater Study
- 2013
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Ingår i: Journal of Neuropathology and Experimental Neurology. - 0022-3069 .- 1554-6578. ; 72:6, s. 452-461
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Tidskriftsartikel (refereegranskat)abstract
- There is no consensus on the pathologic conditions or severity implied by the term "hippocampal sclerosis" (HS). In this study, a panel of experienced neuropathologists evaluated inter-rater agreement for pathologic diagnoses in the hippocampus and proposes consensus recommendations on the use of the term "HS." In a group of 251 cases of HS selected from a large autopsy cohort (1,388; 18%), a coordinating group identified 5 patterns of degenerative or vascular pathology. Four independent neuropathologists assessed a single set of hematoxylin and eosin-stained sections following descriptive definitions to classify the appearances and assign the diagnosis of HS, if appropriate. Diagnostic agreement (range, 36%-70%) was highest for vascular lesions. Subsequent joint review of all cases highlighted the need to identify neurodegenerative lesions using immunohistochemistry. Initial agreement in assigning the diagnosis of HS varied from 0% to 86%. After a joint review, the group recommended that the term "HS" should be applied to all cases with complete/near-complete neuronal loss and gliosis in the subfields of the cornu Ammonis but not to hippocampal microinfarction. Therefore, the etiology of HS must be defined in association with a neurodegenerative process or as "lacking neurodegenerative markers," a pathologic condition presumed to arise from hypoxic/ischemic mechanisms.
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| 42. |
- Rauramaa, T., et al.
(författare)
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TAR-DNA binding protein-43 and alterations in the hippocampus
- 2010
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Ingår i: Abstracts of the XVIIth International Congress of Neuropathology (ICN 2010), Salzburg, Austria, 11-15 September 2010. - : Wiley. ; 20, s. 44-45
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 43. |
- Rauramaa, Tuomas, et al.
(författare)
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TAR-DNA binding protein-43 and alterations in the hippocampus
- 2011
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Ingår i: Journal of neural transmission. - : Springer Science and Business Media LLC. - 0300-9564 .- 1435-1463. ; 118:5, s. 683-689
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Tidskriftsartikel (refereegranskat)abstract
- Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and alpha-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain.
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| 44. |
- Ruscher, Karsten, et al.
(författare)
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Inhibition of CXCL12 signaling attenuates the postischemic immune response and improves functional recovery after stroke.
- 2013
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Ingår i: Journal of Cerebral Blood Flow and Metabolism. - : SAGE Publications. - 1559-7016 .- 0271-678X. ; 33:8, s. 1225-1234
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Tidskriftsartikel (refereegranskat)abstract
- After stroke, brain inflammation in the ischemic hemisphere hampers brain tissue reorganization and functional recovery. Housing rats in an enriched environment (EE) dramatically improves recovery of lost neurologic functions after experimental stroke. We show here that rats housed in EE after stroke induced by permanent occlusion of the middle cerebral artery (pMCAO), showed attenuated levels of proinflammatory cytokines in the ischemic core and the surrounding peri-infarct area, including a significant reduction in the stroke-induced chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor-1 (CXCL12). To mimic beneficial effects of EE, we studied the impact of inhibiting CXCL12 action on functional recovery after transient MCAO (tMCAO). Rats treated with the specific CXCL12 receptor antagonist 1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclo-tetradecan (AMD3100) showed improved recovery compared with saline-treated rats after tMCAO, without a concomitant reduction in infarct size. This was accompanied by a reduction of infiltrating immune cells in the ischemic hemisphere, particularly cluster of differentiation 3-positive (CD3(+)) and CD3(+)/CD4(+) T cells. Spleen atrophy and delayed death of splenocytes, induced by tMCAO, was prevented by AMD3100 treatment. We conclude that immoderate excessive activation of the CXCL12 pathway after stroke contributes to depression of neurologic function after stroke and that CXCR4 antagonism is beneficial for the recovery after stroke.Journal of Cerebral Blood Flow & Metabolism advance online publication, 1 May 2013; doi:10.1038/jcbfm.2013.71.
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| 45. |
- Santillo, Alexander Frizell, et al.
(författare)
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Von Economo neurons are selectively targeted in frontotemporal dementia.
- 2013
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Ingår i: Neuropathology & Applied Neurobiology. - : Wiley. - 1365-2990 .- 0305-1846. ; 39:5, s. 572-579
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Tidskriftsartikel (refereegranskat)abstract
- Von Economo neurons (VEN) are bipolar neurons located in the anterior cingulate cortex (ACC) and the frontoinsular cortex (FI), areas affected early in behavioural variant frontotemporal dementia (bvFTD), in which VEN may constitute a selectively vulnerable cellular population. Aim A previous study has shown a selective loss of VEN in FTD above other neurons in the ACC of FTD. The aim of this study was to confirm this finding in a larger cohort, using a different methodology, and to examine VEN loss in relation to neuropathological severity and molecular pathology. Methods VEN and neighbouring neurons (NN) were quantified in layer Va and Vb of the right dorsal anterior cingulate cortex in 21 cases of behavioural variant FTD, 10 cases of Alzheimer's disease (AD) and 10 non-demented controls (NDC). Results A marked VEN reduction was seen in all FTD cases. In the neuropathologically early cases of FTD (n=13), VEN/10000 NN was significantly reduced by 53 % compared with NDC (p<0.001) and 41% compared with AD (p=0.019), whereas AD patients showed a non-significant 30% reduction of VEN/10000 NN compared with NDC. VEN reduction was present in all protein pathology subgroups. Discussion In conclusion, this study confirms selective sensitivity of VEN in FTD and suggests that VEN loss is an early event in the neurodegenerative process.
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| 46. |
- Santillo, Alexander, et al.
(författare)
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Greater loss of von Economo neurons than loss of layer II and III neurons in behavioral variant frontotemporal dementia.
- 2014
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Ingår i: American Journal of Neurodegenerative Disease. - 2165-591X. ; 3:2, s. 64-71
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies have shown a selective reduction of von Economo neurons (VENs) in behavioral variant frontotemporal dementia (bvFTD). However, the alleged selectivity rests on the comparison between VENs and other neurons in cortical layer V, while it has been established that neurons in the superficial cortical layers (I-III) are particularly affected in bvFTD. The purpose of this study was to examine loss the loss of VENs in comparison with that of non-VEN-neurons of superficial cortical layers. VENs and non-VEN-neurons of cortical layer V and layers II+III were quantified in the anterior cingulate cortex in 16 cases of bvFTD, 12 non-demented controls and 10 cases of Alzheimer's disease (AD). In bvFTD VENs were more depleted than non-VEN-neurons of layers V and II+III. Also, non-VEN-neurons of layer II+III showed a greater density reduction than those of layer V in bvFTD. VEN density was also reduced in AD, albeit to a lesser extent than in bvFTD, and the differences between bvFTD and AD were only significant when relating VEN loss to that of layer V neurons. Our study strengthens the view of VENs as a particularly sensitive neuronal type of bvFTD, and appears to be on a continuum with the loss of other neurons both in bvFTD and between conditions.
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| 47. |
- Sjöbeck, Martin, et al.
(författare)
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Alzheimer's disease (AD) and executive dysfunction. A case-control study on the significance of frontal white matter changes detected by diffusion tensor imaging (DTI).
- 2010
-
Ingår i: Archives of Gerontology and Geriatrics. - : Elsevier BV. - 1872-6976 .- 0167-4943. ; 50, s. 260-266
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Tidskriftsartikel (refereegranskat)abstract
- White matter (WM) changes are frequently seen on structural imaging in AD but the clinical relevance of these changes is uncertain. Frontal WM pathology is often observed upon neuropathological examination in AD. Since frontal cortical/sub-cortical pathology is known to relate to executive dysfunction, the aim was to elucidate if frontal WM changes in AD correlated with executive dysfunction. In all, 15 AD patients and 15 age-matched control cases were investigated in the study, which covered conventional magnetic resonance imaging (MRI), DTI, neuropsychiatric and neuropsychological examinations. Reduced performance on neuropsychological testing of executive function correlated significantly with an increasing degree of frontal WM changes detected by DTI in the AD group, while no such correlation was observed for the controls. Conventional semi-quantitative MRI assessment did not correlate with results on neuropsychological testing of executive function in any of the groups. The structural correlate to certain dimensions of executive dysfunction in AD patients could be related to changes in the deep frontal WM. DTI appears to be more sensitive in the detection of clinically significant WM alterations than conventional semi-quantitative MRI.
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| 48. |
- Svedberg, Lena, 1958, et al.
(författare)
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Comparison of impact on mood, health, and daily living experiences of primary caregivers of walking and non-walking children with cerebral palsy and provided community services support.
- 2010
-
Ingår i: European journal of paediatric neurology. - : Elsevier BV. - 1532-2130 .- 1090-3798. ; 14:3, s. 239-246
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Tidskriftsartikel (refereegranskat)abstract
- Many children with cerebral palsy (CP), especially non-walkers, were previously reported to have cold extremities, pain, sleeping disorders, constipation, and impaired well-being - besides accompanying impairments. Most children had had one or more of these symptoms for more than 1 year, and the symptoms were largely untreated. This study (1) describes mood, health, and daily life experiences of the children's parents; (2) explains impact that the child's impairments and symptoms have on the family; and (3) investigates community services support. Information in this study was gathered from parents of 106 children, ages 5-16, with CP, who lived in northern Sweden. Compared with parents of walkers, parents with non-walking children and several disorders were more frequently anxious for their children's physical and psychological health; often experienced restricted time for themselves; reported frequent daily living interferences; and stated that their health was affected due to the child's health. 10 percent of all families reported that their need of community services support was unmet. To improve health and to provide good community services support for the entire family, regular follow-up and evaluation of the child's treatment and family support are important.
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| 49. |
- Tiselius, Elisabet, 1967-
(författare)
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Experience and Expertise in Conference Interpreting : An investigation of Swedish conference interpreters
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Avhandlingen undersöker tolkningsprocessen och tolkprodukten hos konferenstolkar med olika lång tolkerfarenhet. Detta görs utifrån expertteorin (jmf Ericsson, Charness och Hoffman 2007) tillämpad på tolkning. Enligt expertteorin använder mycket skickliga utövare, oberoende av fält, samma typer av processer och strategier för att nå den absoluta toppen inom sitt gebit. En viktig del av expertteorin är medveten eller avsiktlig övning (deliberate practice), en särskild typ av övning som mycket skickliga utövare använder sig av för att förbättra sin insats.Avhandlingen bygger på fyra olika studier om två olika grupper av deltagare. Deltagarna simultantolkar ett eller två tal från engelska till svenska. Två grupper – en tvärsnittsgrupp med nio deltagare på tre olika tolkerfarenhetsnivåer (ingen erfarenhet, kort erfarenhet och lång erfarenhet) samt en longitudinellgrupp med tre deltagare som spelats in vid två olika tillfällen med 15 års mellanrum – analyserades utifrån både process och produkt data. Tolkprocessen studerades genom att analysera och kategorisera process problem, monitorering och tolkstrategier som tolkarna rapporterat om under retrospektion efter tolkning. Tolkprodukten analyserades genom holistiska bedömningsskalor, en för förståelighet och en för nivån på informationsöverföring. Vidare genomfördes också djupintervjuer med deltagarna i det longitudinella materialet. Syftet var att undersöka hur de uppfattade medveten/avsiktlig övning och hur de såg på sin utveckling och övning av tolkfärdigheten. En viktig del av avhandlingen, förutom resultaten, är utvecklingen av de holistiska bedömningsskalorna (utvecklade från Carroll 1966) och utvecklingen av metoden i djupintervjustudien.Slutsatsen i avhandlingen är att det finns en mätbar skillnad i tolkfärdigheten mellan tolkar med liten eller ingen tolkerfarenhet och tolkar med lång tolkerfarenhet. Denna slutsats fick dock inte stöd i det longitudinella (och intra-individuella) materialet. Skillnaderna mellan grupperna i tvärsnittsmaterialet var också tydliga i processdata. Erfarna tolkar stöter på färre process problem än tolkar med kortare erfarenhet. Det fanns också tydliga skillnader vad gäller förekomsterna av monitorering (alltså kontroll av tolkprocessen och produktionen) mellan erfarna tolkar och övriga deltagare. Monitorering verkar vara en skiljelinje mellan erfarna och oerfarna tolkar, de erfarna tolkarna hade mer process kapacitet tillgänglig för att monitorera sig själva. Detta stöddes också till viss del av djupintervjuerna, där deltagarna rapporterade hur de ständigt utvärderar sig själva i syfte att förbättra sin insats. Ett nyckelantagande som slogs fast i början av projektet – nämligen att erfarna tolkar skulle hävda i djupintervjuerna att de ägnade mycket tid åt att öva färdigheten – fick, till författarens förvåning, inte stöd. Tolkarna rapporterade om många övningslika aktiviteter, men hävdade samtidigt att de inte övade.Avhandlingen avslutas genom ett önskemål om fler studier med fokus på medveten/avsiktlig övning bland tolkar. Dessutom föreslår författaren också att termen “experttolk” eller “expert” ska användas med stor försiktighet i forskningsstudier om just expertkunnande i tolkning. Författaren efterlyser också en bredare diskussion om expertkunnande och medveten/avsiktlig övning.
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