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Sökning: WFRF:(Fellman Vineta) > (2005-2009) > (2006)

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2.
  • Fellman, Vineta, et al. (författare)
  • Cortical auditory event-related potentials in newborn infants.
  • 2006
  • Ingår i: Seminars in Fetal & Neonatal Medicine. - : Elsevier BV. - 1878-0946 .- 1744-165X. ; 11:6, s. 452-458
  • Tidskriftsartikel (refereegranskat)abstract
    • The possibility of recording changes in electroencephalography potentials following perception of sound was reported several decades ago. The recent expanding research on auditory cortical event-retated potentials (AERPs) for assessing sound discrimination abilities in children and infants has indicated that several methodological issues need to be addressed before it can be implemented in clinical practice. Latencies, polarities, and amplitudes of the responses change with gestational age and during infancy. Thus, the maturation of the infant must be considered when designing stimulus paradigms and interpreting the responses. Of healthy newborn infants, only about 80% will show mismatch negativity, the automatic change detection of the auditory stimuli. Currently, the AERP method cannot be applied in clinical practice in the neonatal period, although the findings in healthy newborns at risk for dyslexia are promising. Further research will elucidate the possibility of developing AERPs as a possible early screening method during infancy for later dyslexia or cognitive dysfunction.
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3.
  • Fellman, Vineta (författare)
  • De GRACILA barnen
  • 2006
  • Ingår i: Finska Läkaresällskapets Handlingar. - 0015-2501. ; 166:2, s. 75-80
  • Tidskriftsartikel (refereegranskat)abstract
    • GRACILE-syndromet (Fellmans syndrom, MIM 603358) hör till det fi nländska genetiska sjukdomsarvet. Sjukdomen är orsakad av en missens mutation (S78G) i BCS1L, ett protein som fungerar som en “chaperon” eller sammankopplande länk vid bildning av komplex III i andningskedjan. Syndromet uttrycker sig som en grav tillväxthämning redan under fostertiden, och efter födseln utvecklar barnet en uttalad metabolisk acidos pga. av nedsatt funktion i komplex III. Övriga symtom är proximal tubulopati, nedsatt leverfunktion med cirrhos och uttalad järnupplagring, störd järnmetabolism och tidig död. Diagnosen ställs med hjälp av mutationen, alla barn av fi nländskt ursprung har haft samma homozygota mutation S78G. I andra länder förekommer olika mutationer i BCS1L och fenotypen varierar. Behandlingen är än så länge enbart symtomatisk.
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4.
  • Fellman, Vineta (författare)
  • Mitochondrial complex III deficiencies in the newborn infant.
  • 2006
  • Ingår i: Drug Discovery Today: Disease Mechanisms. - : Elsevier BV. - 1740-6765. ; 3:4, s. 421-427
  • Tidskriftsartikel (refereegranskat)abstract
    • New mechanisms for respiratory chain complex III diseases have recently been reported. Deletions, rearrangements and tRNA mutations of mitochondrial DNA cause deficiencies in several complexes. Mutations in the only complex III subunit encoded by mitochondrial DNA, cytochrome b, cause variable clinical phenotypes, such as cardiomyopathy or multisystemic dysfunction after birth. The homozygous serine78alanine mutation in the complex III assembling protein, BCS1L, causes a distinct phenotype, the GRACILE syndrome, whereas in other BCS1L mutations, the clinical picture is variable, but tubulopathy and liver dysfunction are typical.
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5.
  • Sambeth, A, et al. (författare)
  • Newborns discriminate novel from harmonic sounds: A study using magnetoencephalography
  • 2006
  • Ingår i: Clinical Neurophysiology. - : Elsevier BV. - 1872-8952 .- 1388-2457. ; 117:3, s. 496-503
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: We investigated whether newborns respond differently to novel and deviant sounds during quiet sleep. Methods: Twelve healthy neonates were presented with a three-stimulus oddball paradigm, consisting of frequent standard (76%), infrequent deviant (12%), and infrequent novel stimuli (12%). The standards and deviants were counterbalanced between the newborns and consisted of 500 and 750 Hz tones with two upper harmonics. The novel stimuli contained animal, human, and mechanical sounds. All stimuli had a duration of 300 ms and the stimulus onset asynchrony was 1 s. Evoked magnetic responses during quiet sleep were recorded and averaged offline. Results: Two deflections peaking at 345 and 615 ms after stimulus onset were observed in the evoked responses of most of the newborns. The first deflection was larger to novel and deviant stimuli than to the standard and, furthermore, larger to novel than to deviant stimuli. The second deflection was larger to novel and deviant stimuli than to standards, but did not differ between the novels and deviants. Conclusions: The two deflections found in the present study reflect different mechanisms of auditory change detection and discriminative processes. Significance: The early brain indicators of novelty detection may be crucial in assessing the normal and abnormal cortical function in newborns. Further, studying evoked magnetic fields to complex auditory stimulation in healthy newborns is needed for studying the newborns at-risk for cognitive or language problems. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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  • Resultat 1-5 av 5
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tidskriftsartikel (5)
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refereegranskat (5)
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Fellman, Vineta (5)
Huotilainen, Minna (1)
Huotilainen, M (1)
Sambeth, A (1)
Kushnerenko, E (1)
Pihko, E (1)
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Lunds universitet (5)
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Engelska (4)
Svenska (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (5)
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