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Träfflista för sökning "WFRF:(Foulkes WD) srt2:(2005-2009);srt2:(2007)"

Sökning: WFRF:(Foulkes WD) > (2005-2009) > (2007)

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Numrering	Referens	Omslagsbild	Hitta
1.	Camp, NJ, et al. (författare) Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics 2007 Ingår i: Human molecular genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 16:11, s. 1271-1278 Tidskriftsartikel (refereegranskat)
2.	Kotsopoulos, J, et al. (författare) Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. 2007 Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 1573-7217 .- 0167-6806. ; 105:2, s. 221-228 Tidskriftsartikel (refereegranskat)abstract An early age at first full-term birth is associated with a reduction in the subsequent development of breast cancer among women in the general population. A similar effect has not yet been reported among women who carry an inherited BRCA1 or BRCA2 mutation. We conducted a matched case–control study on 1816 pairs of women with a BRCA1 (n = 1405) or BRCA2 (n = 411) mutation in an attempt to elucidate the relationship between age at first full-term pregnancy and the risk of developing breast cancer. Information about the age at first childbirth and other pregnancy-related variables was derived from a questionnaire administered to women during the course of genetic counselling. There was no difference in the mean age at first full-term birth in the cases and controls (24.9 years vs. 24.8 years; P = 0.81, respectively). Compared to women whose first child was born at or before 18 years of age, a later age at first full-term birth did not influence the risk of developing breast cancer (OR = 1.00 per year; 95% CI 0.98–1.03; P-trend = 0.67). Stratification by mutation status did not affect the results. These findings suggest that an early first full-term birth does not confer protection against breast cancer in BRCA mutation carriers. Nonetheless, BRCA mutation carriers opting for a prophylactic oophorectomy as a breast and/or ovarian cancer risk-reducing strategy should complete childbearing prior to age 40 when this prevention modality is most effective.

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Moller, P. (2); Foulkes, WD (2); Olsson, Håkan (1); SCHAID, DJ (1); EASTON, D (1); Giles, GG (1); visa fler...; Hopper, JL (1); Severi, G (1); Lubinski, J (1); English, DR (1); Couch, F (1); Whittemore, AS (1); Gronberg, H (1); Tammela, TLJ (1); Schleutker, J (1); Xu, JF (1); Thibodeau, SN (1); McDonnell, SK (1); Stanford, JL (1); Maier, C (1); Isaacs, WB (1); Wiklund, F (1); Ostrander, EA (1); Cooney, KA (1); Johanneson, B (1); Isaacs, C (1); Randall, S. (1); Eisen, A (1); Pasini, Barbara (1); Domchek, S. (1); Offit, K. (1); Eeles, R. (1); Neuhausen, SL (1); Emanuelsson, Monica (1); Daly, Mark (1); Maehle, L (1); George, A (1); Tung, N (1); Camp, NJ (1); Cannon-Albright, LA (1); Emanuelsson, M (1); Lynch, HT (1); Farnham, JM (1); Baffoe-Bonnie, AB (1); Powell, I (1); Bailey-Wilson, JE (1); Carpten, JD (1); Badzioch, MD (1); Oakley-Girvan, I (1); Hsieh, CL (1); visa färre...

Lärosäte: Umeå universitet (1); Lunds universitet (1); Karolinska Institutet (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (1)

År: 2007 (2)Ta bort avgränsningen

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