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Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Wolpin, Brian M. (author)
Rizzato, Cosmeri (author)
Kraft, Peter (author)
show more...
Kooperberg, Charles (author)
Petersen, Gloria M. (author)
Wang, Zhaoming (author)
Arslan, Alan A. (author)
Beane-Freeman, Laura (author)
Bracci, Paige M. (author)
Buring, Julie (author)
Canzian, Federico (author)
Duell, Eric J. (author)
Gallinger, Steven (author)
Giles, Graham G. (author)
Goodman, Gary E. (author)
Goodman, Phyllis J. (author)
Jacobs, Eric J. (author)
Kamineni, Aruna (author)
Klein, Alison P. (author)
Kolonel, Laurence N. (author)
Kulke, Matthew H. (author)
Li, Donghui (author)
Malats, Nuria (author)
Olson, Sara H. (author)
Risch, Harvey A. (author)
Sesso, Howard D. (author)
Visvanathan, Kala (author)
White, Emily (author)
Zheng, Wei (author)
Abnet, Christian C. (author)
Albanes, Demetrius (author)
Andreotti, Gabriella (author)
Austin, Melissa A. (author)
Barfield, Richard (author)
Basso, Daniela (author)
Berndt, Sonja I. (author)
Boutron-Ruault, Marie-Christine (author)
Brotzman, Michelle (author)
Buechler, Markus W. (author)
Bueno-de-Mesquita, H. Bas (author)
Bugert, Peter (author)
Burdette, Laurie (author)
Campa, Daniele (author)
Caporaso, Neil E. (author)
Capurso, Gabriele (author)
Chung, Charles (author)
Cotterchio, Michelle (author)
Costello, Eithne (author)
Elena, Joanne (author)
Funel, Niccola (author)
Gaziano, J. Michael (author)
Giese, Nathalia A. (author)
Goggins, Michael (author)
Gorman, Megan J. (author)
Gross, Myron (author)
Haiman, Christopher A. (author)
Hassan, Manal (author)
Helzlsouer, Kathy J. (author)
Henderson, Brian E. (author)
Holly, Elizabeth A. (author)
Hu, Nan (author)
Hunter, David J. (author)
Innocenti, Federico (author)
Jenab, Mazda (author)
Kaaks, Rudolf (author)
Key, Timothy J. (author)
Khaw, Kay-Tee (author)
Klein, Eric A. (author)
Kogevinas, Manolis (author)
Krogh, Vittorio (author)
Kupcinskas, Juozas (author)
Kurtz, Robert C. (author)
LaCroix, Andrea (author)
Landi, Maria T. (author)
Landi, Stefano (author)
Le Marchand, Loic (author)
Mambrini, Andrea (author)
Mannisto, Satu (author)
Milne, Roger L. (author)
Nakamura, Yusuke (author)
Oberg, Ann L. (author)
Owzar, Kouros (author)
Patel, Alpa V. (author)
Peeters, Petra H. M. (author)
Peters, Ulrike (author)
Pezzilli, Raffaele (author)
Piepoli, Ada (author)
Porta, Miquel (author)
Real, Francisco X. (author)
Riboli, Elio (author)
Rothman, Nathaniel (author)
Scarpa, Aldo (author)
Shu, Xiao-Ou (author)
Silverman, Debra T. (author)
Soucek, Pavel (author)
Sund, Malin (author)
Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
Talar-Wojnarowska, Renata (author)
Taylor, Philip R. (author)
Theodoropoulos, George E. (author)
Thornquist, Mark (author)
Tjonneland, Anne (author)
Tobias, Geoffrey S. (author)
Trichopoulos, Dimitrios (author)
Vodicka, Pavel (author)
Wactawski-Wende, Jean (author)
Wentzensen, Nicolas (author)
Wu, Chen (author)
Yu, Herbert (author)
Yu, Kai (author)
Zeleniuch-Jacquotte, Anne (author)
Hoover, Robert (author)
Hartge, Patricia (author)
Fuchs, Charles (author)
Chanock, Stephen J. (author)
Stolzenberg-Solomon, Rachael S. (author)
Amundadottir, Laufey T. (author)
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 (creator_code:org_t)
2014-09-01
2014
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 46:9, s. 994-
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 x 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 x 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 x 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 x 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 x 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 x 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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art (subject category)

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By the author/editor
Wolpin, Brian M.
Rizzato, Cosmeri
Kraft, Peter
Kooperberg, Char ...
Petersen, Gloria ...
Wang, Zhaoming
show more...
Arslan, Alan A.
Beane-Freeman, L ...
Bracci, Paige M.
Buring, Julie
Canzian, Federic ...
Duell, Eric J.
Gallinger, Steve ...
Giles, Graham G.
Goodman, Gary E.
Goodman, Phyllis ...
Jacobs, Eric J.
Kamineni, Aruna
Klein, Alison P.
Kolonel, Laurenc ...
Kulke, Matthew H ...
Li, Donghui
Malats, Nuria
Olson, Sara H.
Risch, Harvey A.
Sesso, Howard D.
Visvanathan, Kal ...
White, Emily
Zheng, Wei
Abnet, Christian ...
Albanes, Demetri ...
Andreotti, Gabri ...
Austin, Melissa ...
Barfield, Richar ...
Basso, Daniela
Berndt, Sonja I.
Boutron-Ruault, ...
Brotzman, Michel ...
Buechler, Markus ...
Bueno-de-Mesquit ...
Bugert, Peter
Burdette, Laurie
Campa, Daniele
Caporaso, Neil E ...
Capurso, Gabriel ...
Chung, Charles
Cotterchio, Mich ...
Costello, Eithne
Elena, Joanne
Funel, Niccola
Gaziano, J. Mich ...
Giese, Nathalia ...
Goggins, Michael
Gorman, Megan J.
Gross, Myron
Haiman, Christop ...
Hassan, Manal
Helzlsouer, Kath ...
Henderson, Brian ...
Holly, Elizabeth ...
Hu, Nan
Hunter, David J.
Innocenti, Feder ...
Jenab, Mazda
Kaaks, Rudolf
Key, Timothy J.
Khaw, Kay-Tee
Klein, Eric A.
Kogevinas, Manol ...
Krogh, Vittorio
Kupcinskas, Juoz ...
Kurtz, Robert C.
LaCroix, Andrea
Landi, Maria T.
Landi, Stefano
Le Marchand, Loi ...
Mambrini, Andrea
Mannisto, Satu
Milne, Roger L.
Nakamura, Yusuke
Oberg, Ann L.
Owzar, Kouros
Patel, Alpa V.
Peeters, Petra H ...
Peters, Ulrike
Pezzilli, Raffae ...
Piepoli, Ada
Porta, Miquel
Real, Francisco ...
Riboli, Elio
Rothman, Nathani ...
Scarpa, Aldo
Shu, Xiao-Ou
Silverman, Debra ...
Soucek, Pavel
Sund, Malin
Talar-Wojnarowsk ...
Taylor, Philip R ...
Theodoropoulos, ...
Thornquist, Mark
Tjonneland, Anne
Tobias, Geoffrey ...
Trichopoulos, Di ...
Vodicka, Pavel
Wactawski-Wende, ...
Wentzensen, Nico ...
Wu, Chen
Yu, Herbert
Yu, Kai
Zeleniuch-Jacquo ...
Hoover, Robert
Hartge, Patricia
Fuchs, Charles
Chanock, Stephen ...
Stolzenberg-Solo ...
Amundadottir, La ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Nature Genetics
By the university
Umeå University

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