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- Gaillard, R. C., et al.
(författare)
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Overall and cause-specific mortality in GH-deficient adults on GH replacement
- 2012
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Ingår i: European Journal of Endocrinology. - : Oxford University Press (OUP). - 0804-4643 .- 1479-683X. ; 166:6, s. 1069-1077
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Hypopituitarism is associated with an increased mortality rate but the reasons underlying this have not been fully elucidated. The purpose of this study was to evaluate mortality and associated factors within a large GH-replaced population of hypopituitary patients. Design: In KIMS (Pfizer International Metabolic Database) 13 983 GH-deficient patients with 69 056 patient-years of follow-up were available. Methods: This study analysed standardised mortality ratios (SMRs) by Poisson regression. IGF1 SDS was used as an indicator of adequacy of GH replacement. Statistical significance was set to P<0.05. Results: All-cause mortality was 13% higher compared with normal population rates (SMR, 1.13; 95% confidence interval, 1.04-1.24). Significant associations were female gender, younger age at follow-up, underlying diagnosis of Cushing's disease, craniopharyngioma and aggressive tumour and presence of diabetes insipidus. After controlling for confounding factors, there were statistically significant negative associations between IGF1 SDS after 1, 2 and 3 years of GH replacement and SMR. For cause-specific mortality there was a negative association between 1-year IGF1 SDS and SMR for deaths from cardiovascular diseases (P=0.017) and malignancies (P=0.044). Conclusions: GH-replaced patients with hypopituitarism demonstrated a modest increase in mortality rate; this appears lower than that previously published in GH-deficient patients. Factors associated with increased mortality included female gender, younger attained age, aetiology and lower IGF1 SDS during therapy. These data indicate that GH replacement in hypopituitary adults with GH deficiency may be considered a safe treatment.
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| 4. |
- Ogawa, Y., et al.
(författare)
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Upper atmosphere cooling over the past 33 years
- 2014
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Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 41:15, s. 5629-5635
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Tidskriftsartikel (refereegranskat)abstract
- Theoretical models and observations have suggested that the increasing greenhouse gas concentration in the troposphere causes the upper atmosphere to cool and contract. However, our understanding of the long-term trends in the upper atmosphere is still quite incomplete, due to a limited amount of available and well-calibrated data. The European Incoherent Scatter radar has gathered data in the polar ionosphere above TromsO for over 33years. Using this long-term data set, we have estimated the first significant trends of ion temperature at altitudes between 200 and 450km. The estimated trends indicate a cooling of 10-15K/decade near the F region peak (220-380km altitude), whereas above 400km the trend is nearly zero or even warming. The height profiles of the observed trends are close to those predicted by recent atmospheric general circulation models. Our results are the first quantitative confirmation of the simulations and of the qualitative expectations.
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| 5. |
- Pellinen-Wannberg, Asta, et al.
(författare)
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E region ionization enhancement over northern Scandinavia during the 2002 Leonids
- 2014
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Ingår i: 2014 XXXITH URSI GENERAL ASSEMBLY AND SCIENTIFIC SYMPOSIUM (URSI GASS). - : IEEE. - 9781467352253
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Konferensbidrag (refereegranskat)abstract
- Intensive E-region ionization was observed with the EISCAT UHF radar during the 2002 Leonids meteor shower. The levels of the geomagnetic disturbance were low during the event. Thus the ionization cannot be explained by intensive precipitation. The layer was 30-40 km thick, so it cannot be classified as a sporadic E-layer (often associated to ions of meteoric origin). These are typically only about km-wide. Incoherent scatter radars have never so far reported any notable meteor shower-related increases in the average background ionization. The 2002 Leonid storm flux, however, was so high that it, if any, might be able to induce such an event. Whether meteors in general can cause such an excess E-region ionization during an intensive shower is discussed. The University of Leeds CABMOD model is used to estimate deposition rates of individual meteors and to relate the results to the predicted Leonid flux values in free space and observed ionization on November 19, 2002.
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| 6. |
- Pellinen-Wannberg, Asta K., et al.
(författare)
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Strong E region ionization caused by the 1767 trail during the 2002 Leonids
- 2014
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Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 119:9, s. 7880-7888
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Tidskriftsartikel (refereegranskat)abstract
- Intensive E region ionization extending up to 140 km altitude and lasting for several hours was observed with the European Incoherent Scatter (EISCAT) UHF radar during the 2002 Leonids meteor shower maximum. The level of global geomagnetic disturbance as well as the local geomagnetic and auroral activity in northern Scandinavia were low during the event. Thus, the ionization cannot be explained by intensive precipitation. The layer was 30-40 km thick, so it cannot be classified as a sporadic E layer which are typically just a few kilometers wide. Incoherent scatter radars have not to date reported any notable meteor shower-related increases in the average background ionization. The 2002 Leonids storm flux, however, was so high that it might have been able to induce such an event. The Chemical Ablation Model is used to estimate deposition rates of individual meteors. The resulting electron production, arising from hyperthermal collisions of ablated atoms with atmospheric molecules, is related to the predicted Leonid flux values and observed ionization on 19 November 2002. The EISCAT Svalbard Radar (ESR) located at some 1000 km north of the UHF site did not observe any excess ionization during the same period. The high-latitude electrodynamic conditions recorded by the SuperDARN radar network show that the ESR was within a strongly drifting convection cell continuously fed by fresh plasma while the UHF radar was outside the polar convection region maintaining the ionization.
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