| 1. |
|
|
| 2. |
- Schepens, Marloes A. A., et al.
(författare)
-
Supplemental calcium attenuates the colitis-related increase in diarrhea, intestinal permeability, and extracellular matrix breakdown in HLA-B27 transgenic rats
- 2009
-
Ingår i: Journal of Nutrition. - : Elsevier BV. - 0022-3166 .- 1541-6100. ; 139:8, s. 1525-1533
-
Tidskriftsartikel (refereegranskat)abstract
- We have shown in several controlled rat and human infection studies that dietary calcium improves intestinal resistance and strengthens the mucosal barrier. Reinforcement of gut barrier function may alleviate inflammatory bowel disease (IBD). Therefore, we investigated the effect of supplemental calcium on spontaneous colitis development in an experimental rat model of IBD. HLA-B27 transgenic rats were fed a purified high-fat diet containing either a low or high calcium concentration (30 and 120 mmol CaHPO4/kg diet, respectively) for almost 7 wk. Inert chromium EDTA (CrEDTA) was added to the diets to quantify intestinal permeability by measuring urinary CrEDTA excretion. Relative fecal wet weight was determined to quantify diarrhea. Colonic inflammation was determined histologically and by measuring mucosal interleukin (IL)-1beta. In addition, colonic mucosal gene expression of individual rats was analyzed using whole-genome microarrays. The calcium diet significantly inhibited the increase in intestinal permeability and diarrhea with time in HLA-B27 rats developing colitis compared with the control transgenic rats. Mucosal IL-1beta levels were lower in calcium-fed rats and histological colitis scores tended to be lower (P = 0.08). Supplemental calcium prevented the colitis-induced increase in the expression of extracellular matrix remodeling genes (e.g. matrix metalloproteinases, procollagens, and fibronectin), which was confirmed by quantitative real-time PCR and gelatin zymography. In conclusion, dietary calcium ameliorates several important aspects of colitis severity in HLA-B27 transgenic rats. Reduction of mucosal irritation by luminal components might be part of the mechanism. These results show promise for supplemental calcium as effective adjunct therapy for IBD.
|
|
| 3. |
|
|
| 4. |
- Taal, Cees H., et al.
(författare)
-
An Evaluation of Objective Quality Measures for Speech Intelligibility Prediction
- 2009
-
Konferensbidrag (refereegranskat)abstract
- In this research various objective quality measures are evaluated in order to predict the intelligibility for a wide range of non-linearly processed speech signals and speech degraded by additive noise. The obtained results are compared with the prediction results of a more advanced perceptual-based model proposed by Dau et al. and an objective intelligibility measure, namely the coherence speech intelligibility index (cSII). These tests are performed in order to gain more knowledge between the link of speech-quality and speech-intelligibility and may help us to exploit the extensive research done into the field of speech-quality for speech-intelligibility. It is shown that cSII does not necessarily show better performance compared to conventional objective (speech)-quality measures. In general, the DAU-model is the only method with reasonable results for all processing conditions.
|
|
