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Träfflista för sökning "WFRF:(Holton Janice) srt2:(2005-2009)"

Sökning: WFRF:(Holton Janice) > (2005-2009)

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1.
  • Brundin, Patrik, et al. (författare)
  • Research in motion: the enigma of Parkinson's disease pathology spread.
  • 2008
  • Ingår i: Nature Reviews Neuroscience. - : Springer Science and Business Media LLC. - 1471-003X .- 1471-0048. ; 9:10, s. 741-745
  • Forskningsöversikt (refereegranskat)abstract
    • Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.
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2.
  • Li, Jia-Yi, et al. (författare)
  • Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
  • 2008
  • Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 14, s. 501-503
  • Tidskriftsartikel (refereegranskat)abstract
    • Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.
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3.
  • Paviour, Dominic C, et al. (författare)
  • Neuronal intranuclear inclusion disease : Report on a case originally diagnosed as dopa-responsive dystonia with lewy bodies
  • 2005
  • Ingår i: Movement Disorders. - : Wiley. - 0885-3185 .- 1531-8257. ; 20:10, s. 1345-1349
  • Tidskriftsartikel (refereegranskat)abstract
    • Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder with a heterogeneous clinical picture characterized by the presence of eosinophilic intranuclear inclusions in neuronal and glial cells. We describe a case, reported 12 years ago as dopa-responsive dystonia (DRD) with Lewy body pathology. Pathological re-examination has led to a revised diagnosis of neuronal intranuclear inclusion disease. This rare condition, which may be diagnosed in life with a full thickness rectal biopsy, needs to be considered in the differential diagnosis of any case presenting as progressive juvenile parkinsonism (JP) or dystonia. © 2005 Movement Disorder Society.
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  • Resultat 1-3 av 3

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