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- Ghabboun, Jamal, et al.
(författare)
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Mapping of Embedded Functionalized Carbon Nanotubes in Poly(vinyl alcohol)/Nanotube Composite Using Electrostatic Force Microscopy
- 2012
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Ingår i: IJPAC. International journal of polymer analysis and characterization. - : Taylor & Francis. - 1023-666X .- 1563-5341. ; 17:4, s. 268-277
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Tidskriftsartikel (refereegranskat)abstract
- In the present study, electrostatic force microscopy (EFM) was used as a nondestructive tool for mapping individual functionalized single-wall carbon nanotubes (SWCNTs) incorporated in a poly(vinyl alcohol) (PVA)/CNT composite. The nanocomposite film was prepared using a spin-coating technique. The FT-IR results show esterification between the PVA and the functionalized CNTs. Furthermore, AFM images show that SWCNTs are embedded inside the PVA film. The distribution and orientation of the embedded CNTs were mapped using EFM phase imaging through investigation of the polarizability signal elicited from the CNTs. Results show that polarized SWCNTs are dispersed and oriented in different directions at different depths in the PVA matrix.
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- Lekman, Magnus, et al.
(författare)
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The genetic interacting landscape of 63 candidate genes in Major Depressive Disorder : an explorative study
- 2014
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Ingår i: BioData Mining. - : Springer Science and Business Media LLC. - 1756-0381. ; 7, s. 19-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Genetic contributions to major depressive disorder (MDD) are thought to result from multiple genes interacting with each other. Different procedures have been proposed to detect such interactions. Which approach is best for explaining the risk of developing disease is unclear. This study sought to elucidate the genetic interaction landscape in candidate genes for MDD by conducting a SNP-SNP interaction analysis using an exhaustive search through 3,704 SNP-markers in 1,732 cases and 1,783 controls provided from the GAIN MDD study. We used three different methods to detect interactions, two logistic regressions models (multiplicative and additive) and one data mining and machine learning (MDR) approach. Results: Although none of the interaction survived correction for multiple comparisons, the results provide important information for future genetic interaction studies in complex disorders. Among the 0.5% most significant observations, none had been reported previously for risk to MDD. Within this group of interactions, less than 0.03% would have been detectable based on main effect approach or an a priori algorithm. We evaluated correlations among the three different models and conclude that all three algorithms detected the same interactions to a low degree. Although the top interactions had a surprisingly large effect size for MDD (e. g. additive dominant model P-uncorrected = 9.10E-9 with attributable proportion (AP) value = 0.58 and multiplicative recessive model with P-uncorrected = 6.95E-5 with odds ratio (OR estimated from beta 3) value = 4.99) the area under the curve (AUC) estimates were low (< 0.54). Moreover, the population attributable fraction (PAF) estimates were also low (< 0.15). Conclusions: We conclude that the top interactions on their own did not explain much of the genetic variance of MDD. The different statistical interaction methods we used in the present study did not identify the same pairs of interacting markers. Genetic interaction studies may uncover previously unsuspected effects that could provide novel insights into MDD risk, but much larger sample sizes are needed before this strategy can be powerfully applied.
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- Sowwan, Mukhles, et al.
(författare)
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Growth of 2,2-Biimidazole-Based Nanorods on Mica Substrate
- 2010
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Ingår i: Journal of Nanomaterials. - : Hindawi Publishing Corporation. - 1687-4110 .- 1687-4129. ; 2010
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Tidskriftsartikel (refereegranskat)abstract
- The synthesis of a one-dimensional single-stranded helix using the crystallization of silver (I) nitrate and 2,2-biimidazole has promising potential for use in the area of nanotechnology mainly because of its unique electrical properties and its structural similarity to naturally occurring nucleic acids. In this study, we report a new method for the deposition and growth of 2,2-biimidazole- based nanorods on mica substrates by employing a complex solution of silver nitrate (I) and 2,2-biimidazole. The morphology and electrical polarizability of the prepared nanorods are investigated by tapping mode atomic force microscopy (AFM) and noncontact electrostatic force microscopy (EFM). The experimental results show highly polarizable and singly separated nanorods oriented in three preponderant directions. In addition, we show that the active K+ ions on the mica surface are required for the formation of these nanorods. Additionally, these potassium ions are a critical factor in controlling the nucleation and morphology of nanostructures.
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