| 1. |
- Ohlson, Sten, et al.
(författare)
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Toward high-throughput drug screening on a chip-based parallell affinity separation platform
- 2010
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Ingår i: Journal of Separation Science. - : Wiley. - 1615-9306 .- 1615-9314. ; 33:17-18, s. 2575-2581
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Tidskriftsartikel (refereegranskat)abstract
- High-throughput screening of compound libraries, including the study of fragments, has become one of the cornerstones in modern drug discovery research. During this process hits are defined that may be developed into valuable leads and eventually into possible drug candidates. In this paper, we have demonstrated that parallel zonal weak affinity chromatography in microcolumns on a chip offers a possible screening format for weakly binding ligands toward a protein target. We used albumin as a model system because this transport protein is well established as a binder (both weak and strong) for drug substances. Bovine serum albumin was immobilized on microparticulate diolsilica particles and then packed into a 24-channel cartridge, which served as the separation platform. Analysis of the obtained chromatograms yielded information about affinity even in the millimolar range. Employing this approach, thousands of substances can be screened in just a day. We feel confident that zonal affinity chromatography will provide a useful technology in the future for performing high-throughput screening.
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| 2. |
- Adler, Jan-Olof, et al.
(författare)
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The upgraded photon tagging facility at the MAX IV Laboratory
- 2013
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier BV. - 0167-5087 .- 0168-9002. ; 715, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- A description is given of the upgraded photon tagging facility at the MAX IV Laboratory. Two magnetic spectrometers are used to momentum analyze post-bremsstrahlung electrons. The tagged photon range extends from 10 to 180 MeV with an energy resolution of about 300 keV. The system has been operated at rates up to 4 x 10(6) photons s(-1) MeV (-1). Different diagnostic tools are described as well as the experimental program.
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| 3. |
- Aguar-Bartolome, P., et al.
(författare)
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Measurement of the gamma p -> K-0 Sigma(+) reaction with the Crystal Ball/TAPS detectors at the Mainz Microtron
- 2013
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 88:4
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Tidskriftsartikel (refereegranskat)abstract
- The gamma p -> K-0 Sigma(+) reaction has been measured from threshold to E-gamma = 1.45 GeV (W-CM = 1.9 GeV) using the Crystal Ball and TAPS multiphoton spectrometers together with the photon tagging facility at the Mainz Microtron MAMI. In the present experiment, this reaction was searched for in the 3 pi(0)p final state, by assuming K-S(0) -> pi(0)pi(0) and Sigma(+) -> pi(0)p. The experimental results include total and differential cross sections as well as the polarization of the recoil hyperon. The new data significantly improve empirical knowledge about the gamma p -> K-0 Sigma(+) reaction in the measured energy range. The results are compared to previous measurements and model predictions. It is demonstrated that adding the present gamma p -> K-0 Sigma(+) results to existing data allowed a better description of this reaction with various models.
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| 4. |
- Aguar-Bartolome, P., et al.
(författare)
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New determination of the eta transition form factor in the Dalitz decay eta -> e(+) e(-) gamma with the Crystal Ball/TAPS detectors at the Mainz Microtron
- 2014
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 89:4
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Tidskriftsartikel (refereegranskat)abstract
- The Dalitz decay eta -> e(+) e(-) gamma has been measured in the gamma p -> eta p reaction with the Crystal Ball and TAPS multiphoton spectrometers, together with the photon-tagging facility at the Mainz Microtron MAMI. The experimental statistic used in this work is one order of magnitude greater than in any previous measurement of eta -> e(+) e(-) gamma. The value obtained for the slope parameter Lambda(-2) of the eta transition form factor, Lambda(-2) = (1.95 +/- 0.15(stat) +/- 0.10(syst)) GeV-2, is in good agreement with recent measurements conducted in eta -> e(+) e(-) gamma and eta -> mu(+) mu(-) gamma decays, as well as with recent form-factor calculations. The uncertainty obtained in the value of Lambda(-2) is lower compared to results from previous measurements of the eta -> e(+) e(-) gamma decay.
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| 5. |
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| 6. |
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| 7. |
- Erni, W., et al.
(författare)
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Technical design report for the PANDA (AntiProton Annihilations at Darmstadt) Straw Tube Tracker
- 2013
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 49:2
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Tidskriftsartikel (refereegranskat)abstract
- This document describes the technical layout and the expected performance of the Straw Tube Tracker (STT), the main tracking detector of the PANDA target spectrometer. The STT encloses a Micro-Vertex-Detector (MVD) for the inner tracking and is followed in beam direction by a set of GEM stations. The tasks of the STT are the measurement of the particle momentum from the reconstructed trajectory and the measurement of the specific energy loss for a particle identification. Dedicated simulations with full analysis studies of certain proton-antiproton reactions, identified as being benchmark tests for the whole PANDA scientific program, have been performed to test the STT layout and performance. The results are presented, and the time lines to construct the STT are described.
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| 8. |
- Fiedler, Markus, et al.
(författare)
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Measurements and analysis of application-perceived throughput via mobile links
- 2011
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Ingår i: Lecture Notes in Computer Science. - : Springer. - 0302-9743 .- 1611-3349. ; 5233, s. 37-69
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Tidskriftsartikel (refereegranskat)abstract
- Application-perceived throughput plays a major role for the performance of networked applications and user experience and thus, for network selection decisions. To support the latter, this tutorial paper investigates the process of user-perceived throughput in GPRS and UMTS systems seen over rather small averaging intervals, based on test traffic mimicking the needs of streaming applications, and analyzes the results with aid of summary statistics. These results reveal a clear influence of the network, seen from variations and autocorrelation of application-perceived throughput mostly on the one-second time scale and indicate that applications have to cope with significant jitter when trying to exploit the nominal throughputs. In GPRS, the promised average throughputs are not reached in downlink direction; instead, significant packet loss occurs. Furthermore, with aid of causality arguments for an equivalent bottleneck, bounds for the extra delay of the first packet sent via mobile links is derived from throughput measurements.
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| 9. |
- Ganenko, V., et al.
(författare)
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Linearly polarized photon beam at MAX-lab
- 2014
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier BV. - 0167-5087 .- 0168-9002. ; 763, s. 137-149
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Tidskriftsartikel (refereegranskat)abstract
- A linearly polarized photon beam has been produced at MAX-lab using the coherent bremsstrahlung of electrons with an energy of 192.6 MeV in a 0.1 mm thick diamond crystal. The intensity and shape of the coherent maxima and their dependence on the crystal orientation are similar to the features observed at higher electron energies (similar to 1 GeV) and are well described by coherent bremsstrahlung theory. The linear polarization of the uncollimated beam at the coherent peak energy approximate to 50-60 MeV is about 20% and can be increased to 40-45% if collimation of half the characteristic angle is used At present the degree of polarization is high enough to allow the study of polarization observables in photo-nuclear reactions at MAX-lab in the energy range from Giant Dipole Resonance up to approximate to 80 MeV. (C) 2014 Elsevier B.V. All rights reserved.
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| 10. |
- Isaksson, Alf, et al.
(författare)
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Grey-Box Identification Based on Horizon Estimation and Nonlinear Optimization
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In applications of (nonlinear) model predictive control a more and more common approach for the state estimation is to use moving horizon estimation, which employs (nonlinear) optimization directly on a model for a whole batch of data. This paper shows that horizon estimation may also be used for joint parameter estimation and state estimation, as long as a bias correction based on the Kalman filter is included. A procedure how to approximate the bias correction for nonlinear systems is outlined.
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