Sökning: WFRF:(Jablonski Kathleen A)
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Interaction Between...
Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors
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- Merino, Jordi (författare)
- Broad Institute,Rovira i Virgili University (URV),Massachusetts General Hospital,Harvard University
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- Jablonski, Kathleen A. (författare)
- George Washington University, Maryland
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- Mercader, Josep M. (författare)
- Massachusetts General Hospital,Broad Institute
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- Kahn, Steven E. (författare)
- VA Puget Sound Health Care System
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- Chen, Ling (författare)
- Broad Institute,Massachusetts General Hospital
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- Harden, Maegan (författare)
- Broad Institute
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- Delahanty, Linda M. (författare)
- Massachusetts General Hospital,Harvard University
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- Araneta, Maria Rosario G. (författare)
- University of California, San Diego
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- Walford, Geoffrey A. (författare)
- Massachusetts General Hospital
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- Jacobs, Suzanne B.R. (författare)
- Massachusetts General Hospital,Broad Institute
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- Ibebuogu, Uzoma N. (författare)
- University of Tennessee
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- Franks, Paul W. (författare)
- Umeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Genetic & Molecular Epidemiology Unit, Lund University Diabetes Centre, Malmo, Sweden; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA,Näringsforskning
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- Knowler, William C. (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Florez, Jose C. (författare)
- Broad Institute,Harvard University,Massachusetts General Hospital
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(creator_code:org_t)
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- 2019-10-21
- 2020
- Engelska 9 s.
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Ingår i: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 69:1, s. 112-120
- Relaterad länk:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- Coronary artery disease (CAD) is more frequent among individuals with dysglycemia. Preventive interventions for diabetes can improve cardiometabolic risk factors (CRFs), but it is unclear whether the benefits on CRFs are similar for individuals at different genetic risk for CAD. We built a 201-variant polygenic risk score (PRS) for CAD and tested for interaction with diabetes prevention strategies on 1-year changes in CRFs in 2,658 Diabetes Prevention Program (DPP) participants. We also examined whether separate lifestyle behaviors interact with PRS and affect changes in CRFs in each intervention group. Participants in both the lifestyle and metformin interventions had greater improvement in the majority of recognized CRFs compared with placebo (P < 0.001) irrespective of CAD genetic risk (Pinteraction > 0.05). We detected nominal significant interactions between PRS and dietary quality and physical activity on 1-year change in BMI, fasting glucose, triglycerides, and HDL cholesterol in individuals randomized to metformin or placebo, but none of them achieved the multiple-testing correction for significance. This study confirms that diabetes preventive interventions improve CRFs regardless of CAD genetic risk and delivers hypothesis-generating data on the varying benefit of increasing physical activity and improving diet on intermediate cardiovascular risk factors depending on individual CAD genetic risk profile.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Diabetes
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Merino, Jordi
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Jablonski, Kathl ...
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Mercader, Josep ...
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Kahn, Steven E.
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Chen, Ling
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Harden, Maegan
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Delahanty, Linda ...
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Araneta, Maria R ...
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Walford, Geoffre ...
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Jacobs, Suzanne ...
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Ibebuogu, Uzoma ...
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Franks, Paul W.
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Knowler, William ...
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Florez, Jose C.
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