| 61. |
- Ewart, L, et al.
(author)
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Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery
- 2018
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In: Annual review of pharmacology and toxicology. - : Annual Reviews. - 1545-4304 .- 0362-1642. ; 58, s. 65-82
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Journal article (peer-reviewed)abstract
- Enhancing the early detection of new therapies that are likely to carry a safety liability in the context of the intended patient population would provide a major advance in drug discovery. Microphysiological systems (MPS) technology offers an opportunity to support enhanced preclinical to clinical translation through the generation of higher-quality preclinical physiological data. In this review, we highlight this technological opportunity by focusing on key target organs associated with drug safety and metabolism. By focusing on MPS models that have been developed for these organs, alongside other relevant in vitro models, we review the current state of the art and the challenges that still need to be overcome to ensure application of this technology in enhancing drug discovery.
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| 62. |
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| 63. |
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| 64. |
- Jang, Y. M., et al.
(author)
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Message from Organizing Chairs
- 2016
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In: 8th International Conference on Ubiquitous and Future Networks, ICUFN 2016. - : IEEE Computer Society. - 2165-8528. ; 2016-August
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Journal article (peer-reviewed)
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| 65. |
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| 66. |
- Karimi, Nasibeh, et al.
(author)
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Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins
- 2018
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In: Cellular and Molecular Life Sciences. - : Springer Science and Business Media LLC. - 1420-682X .- 1420-9071. ; 75:15, s. 2873-2886
-
Journal article (peer-reviewed)abstract
- The isolation of extracellular vesicles (EVs) from blood is of great importance to understand the biological role of circulating EVs and to develop EVs as biomarkers of disease. Due to the concurrent presence of lipoprotein particles, however, blood is one of the most difficult body fluids to isolate EVs from. The aim of this study was to develop a robust method to isolate and characterise EVs from blood with minimal contamination by plasma proteins and lipoprotein particles. Plasma and serum were collected from healthy subjects, and EVs were isolated by size-exclusion chromatography (SEC), with most particles being present in fractions 8-12, while the bulk of the plasma proteins was present in fractions 11-28. Vesicle markers peaked in fractions 7-11; however, the same fractions also contained lipoprotein particles. The purity of EVs was improved by combining a density cushion with SEC to further separate lipoprotein particles from the vesicles, which reduced the contamination of lipoprotein particles by 100-fold. Using this novel isolation procedure, a total of 1187 proteins were identified in plasma EVs by mass spectrometry, of which several proteins are known as EV-associated proteins but have hitherto not been identified in the previous proteomic studies of plasma EVs. This study shows that SEC alone is unable to completely separate plasma EVs from lipoprotein particles. However, combining SEC with a density cushion significantly improved the separation of EVs from lipoproteins and allowed for a detailed analysis of the proteome of plasma EVs, thus making blood a viable source for EV biomarker discovery.
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| 67. |
- Kug, J. S., et al.
(author)
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Two distinct influences of Arctic warming on cold winters over North America and East Asia
- 2015
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In: Nature Geoscience. - : Springer Science and Business Media LLC. - 1752-0894 .- 1752-0908. ; 8:10
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Journal article (peer-reviewed)abstract
- Arctic warming has sparked a growing interest because of its possible impacts on mid-latitude climate(1-5). A number of unusually harsh cold winters have occurred in many parts of East Asia and North America in the past few years(2,6,7), and observational and modelling studies have suggested that atmospheric variability linked to Arctic warming might have played a central role(1,3,4,8-11). Here we identify two distinct influences of Arctic warming which may lead to cold winters over East Asia or North America, based on observational analyses and extensive climate model results. We find that severe winters across East Asia are associated with anomalous warmth in the Barents-Kara Sea region, whereas severe winters over North America are related to anomalous warmth in the East Siberian-Chukchi Sea region. Each regional warming over the Arctic Ocean is accompanied by the local development of an anomalous anticyclone and the downstream development of a mid-latitude trough. The resulting northerly flow of cold air provides favourable conditions for severe winters in East Asia or North America. These links between Arctic and mid-latitude weather are also robustly found in idealized climate model experiments and CMIP5 multi-model simulations. We suggest that our results may help improve seasonal prediction of winter weather and extreme events in these regions.
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| 68. |
- Kulka, U., et al.
(author)
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BIODOSIMETRY AND BIODOSIMETRY NETWORKS FOR MANAGING RADIATION EMERGENCY
- 2018
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In: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 0144-8420 .- 1742-3406. ; 182:1, s. 128-138
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Journal article (peer-reviewed)abstract
- Biological dosimetry enables individual dose reconstruction in the case of unclear or inconsistent radiation exposure situations, especially when a direct measurement of ionizing radiation is not or is no longer possible. To be prepared for large-scale radiological incidents, networking between well-trained laboratories has been identified as a useful approach for provision of the fast and trustworthy dose assessments needed in such circumstances. To this end, various biodosimetry laboratories worldwide have joined forces and set up regional and/or nationwide networks either on a formal or informal basis. Many of these laboratories are also a part of global networks such as those organized by World Health Organization, International Atomic Energy Agency or Global Health Security Initiative. In the present report, biodosimetry networks from different parts of the world are presented, and the partners, activities and cooperation actions are detailed. Moreover, guidance for situational application of tools used for individual dosimetry is given.
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| 69. |
- Lang, Jenny, et al.
(author)
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Reliability study of a RF power amplifier with GaN-on-SiC HEMTs
- 2016
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In: ECS Transactions. - Pennington, N.J. : The Electrochemical Society. - 9781607685395 ; , s. 49-59
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Conference paper (peer-reviewed)abstract
- RF power amplifier demonstrators containing each one GaN-on- SiC, HEMT, CHZ015A-QEG, from UMS in SMD quad-flat noleads package (QFN) were subjected to thermal cycles (TC) and power cycles (PC) and evaluated electrically, thermally and structurally. Two types of lead-free solders (Sn63Pb36Ag2 and SnAgCu (SAC305)) and two types of TIM materials (NanoTIM and TgonTM 805) for PCB attachment to liquid cold plate were tested for thermo-mechanical reliability. Changes in electrical performance of the devices namely reduction of the current saturation value, threshold voltage shift, increase of the leakage current and degradation of the HF performance were observed as a result of an accumulated current stress during PC. No significant changes in the investigated solder or TIM materials were observed.
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| 70. |
- Lang, Jenny, et al.
(author)
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Reliability Study of GaN-onSiC HEMT RF Power Amplifiers
- 2018
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In: Advances in Technology Innovation. ; 3:4, s. 157-165
-
Journal article (peer-reviewed)abstract
- The RF power amplifier demonstrators containing each one GaN-on-SiC, HEMT, CHZ015A-QEG, from UMSin SMD quad-flat no-leads package (QFN) were subjected to thermal cycles (TC) and power cycles (PC) andevaluated electrically, thermally and structurally. Two types of solders, Sn63Pb36Ag2 and lead-free SnAgCu(SAC305), and two types of TIM materials, NanoTIM and TgonTM 805, for PCB attachment to the liquid cold platewere tested for thermo-mechanical reliability. Changes in the electrical performance of the devices, namely thereduction of the current saturation value, threshold voltage shift, increase of the leakage current and degradation ofthe HF performance were observed as a result of an accumulated current stress during PC. No significant changes inthe investigated solder or TIM materials were observed.
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