SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Jansson JO) srt2:(1995-1999)"

Sökning: WFRF:(Jansson JO) > (1995-1999)

  • Resultat 1-8 av 8
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  • Helou, K, et al. (författare)
  • Amplification and overexpression of the hepatocyte growth factor receptor (HGFR/MET) in rat DMBA sarcomas
  • 1999
  • Ingår i: Oncogene. - : Nature Publishing Group. - 0950-9232 .- 1476-5594. ; 18:21, s. 3226-3234
  • Tidskriftsartikel (refereegranskat)abstract
    • In the present study subcutaneous fibrosarcomas were induced by the carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) in rats from F1 generation cross breedings of two different inbred strains. Comparative genomic hybridization (CGH) analysis, which allows detection of DNA sequence copy changes, was applied to one of the tumors and it was found that there were increased copy numbers of sequences at chromosome 4q12-q21 in this tumor. We have previously determined that the loci for the hepatocyte growth factor (Hgf) and hepatocyte growth factor receptor (Hgfr/Met), a protooncogene, are situated in this particular chromosome region. Using probes for the two genes in FISH (fluorescence in situ hybridization) and in Southern blots we found that the Hgfr/Met gene was amplified in five of the 19 sarcomas studied, and that the Hgf gene was coamplified in two of them. Northern and Western blots and tyrosine phosphorylation analysis showed that the HGF receptor was overexpressed and functional in all five tumors, as well as in two additional tumors. In summary, both amplification and overexpression of the Hgfr/Met gene was found in about 25% of DMBA-induced experimental rat sarcomas, and HGF receptor overexpression alone was seen in two additional tumors. Possibly this reflects an involvement in paracrine or autocrine stimulation of growth and invasiveness by HGF. Our finding could provide a rodent model system to increased knowledge about causality and therapy, which may be applicable to the sizeable fraction of human musculoskeletal tumors displaying MET overexpression.
  •  
5.
  • McGinnis, S, et al. (författare)
  • Use of oxygen-stabilized C-60 films for selective chemical vapor deposition
  • 1997
  • Ingår i: APPLIED PHYSICS LETTERS. - : AMER INST PHYSICS. ; 70:5
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Thin C-60 films exposed to ultraviolet/visible light in the presence of oxygen were used as a selective mask for tungsten chemical vapor deposition on silicon substrates. An uptake of oxygen in the fullerene films as well as a significant increase in the
  •  
6.
  •  
7.
  • Norin, L, et al. (författare)
  • Deposition of transition metal carbide superlattices using C-60 as a carbon source
  • 1998
  • Ingår i: Applied Physics Letters. ; 73:19, s. 2754-2756
  • Tidskriftsartikel (refereegranskat)abstract
    • Epitaxial films of TiC and VC can be deposited at low temperatures on Mg(001) substrates by coevaporation of the metals with C-60 in a ultrahigh vacuum system. This process was used to deposit TiC/VC (001) superlattices on MgO(001) at 400 degrees C. The
  •  
8.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-8 av 8

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy