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1.	Melen, E, et al. (author) Genome-wide association study of body mass index in 23 000 individuals with and without asthma 2013 In: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. - : Wiley. - 1365-2222. ; 43:4, s. 463-474 Journal article (peer-reviewed)
2.	Pedersen, M, et al. (author) Ambient air pollution and low birthweight: a European cohort study (ESCAPE) 2013 In: The Lancet. Respiratory medicine. - 2213-2600. ; 1:9, s. 695-704 Journal article (peer-reviewed)
3.	Pinart, M, et al. (author) Comorbidity and persistence of allergy-related phenotypes in children in the longitudinal MeDALL study 2013 In: EUROPEAN RESPIRATORY JOURNAL. - 0903-1936. ; 42 Conference paper (other academic/artistic)
4.	Pedersen, Marie, et al. (author) Bulky DNA Adducts in Cord Blood, Maternal Fruit-and-Vegetable Consumption, and Birth Weight in a European Mother-Child Study (NewGeneris) 2013 In: Journal of Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 121:10, s. 1200-1206 Journal article (peer-reviewed)abstract Background: Tobacco-smoke, airborne, and dietary exposures to polycyclic aromatic-hydrocarbons (PAHs) have been associated with reduced prenatal growth. Evidence from -biomarker-based studies of low-exposed populations is limited. Bulky DNA adducts in cord blood reflect the prenatal effective dose to several genotoxic agents including PAHs. Objectives: We estimated the association between bulky DNA adduct levels and birth weight in a multicenter study and examined modification of this association by maternal intake of fruits and vegetables during pregnancy. Methods: Pregnant women from Denmark, England, Greece, Norway, and Spain were recruited in 2006-2010. Adduct levels were measured by the 32P-postlabeling technique in white blood cells from 229 mothers and 612 newborns. Maternal diet was examined through questionnaires. Results: Adduct levels in maternal and cord blood samples were similar and positively correlated (median, 12.1 vs. 11.4 adducts in 108 nucleotides; Spearman rank correlation coefficient = 0.66, p < 0.001). Cord blood adduct levels were negatively associated with birth weight, with an estimated difference in mean birth weight of -129 g (95% CI: -233, -25 g) for infants in the highest versus lowest tertile of adducts. The negative association with birth weight was limited to births in Norway, Denmark, and England, the countries with the lowest adduct levels, and was more pronounced in births to mothers with low intake of fruits and vegetables (-248 g; 95% CI: -405, -92 g) compared with those with high intake (-58 g; 95% CI: -206, 90 g). Conclusions: Maternal exposure to genotoxic agents that induce the formation of bulky DNA adducts may affect intrauterine growth. Maternal fruit and vegetable consumption may be protective.

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Type of publication: journal article (3); conference paper (1)

Type of content: peer-reviewed (3); other academic/artistic (1)

Author/Editor: Kogevinas, M (3); Sunyer, J (2); Heinrich, J. (2); Melen, E (2); Kull, I (2); Bernard, C. (1); show more...; Henderson, J. (1); Pedersen, M. (1); Forastiere, F (1); Kumar, A. (1); Törnqvist, Margareta (1); Alexander, Jan (1); Kabesch, M (1); Wright, J (1); Anto, JM (1); Bousquet, J (1); Postma, DS (1); Jarvis, D. (1); Soderhall, C (1); Pershagen, G (1); Braun-Fahrlander, C (1); Becker, A. (1); Sunyer, Jordi (1); Kogevinas, Manolis (1); Pinart, M (1); Koppelman, GH (1); Benet, M (1); Garcia-Aymerich, J (1); Gonzalez, JR (1); Guerra, S (1); Keil, T (1); Wickman, M (1); Gruzieva, O (1); Celedón, JC (1); Michel, S (1); Standl, M (1); Thiering, E. (1); Bindslev-Jensen, C (1); Cirach, M. (1); Brunborg, Gunnar (1); Brunekreef, B (1); Bergstrom, A (1); Farrall, M. (1); Flexeder, C (1); Heude, B (1); Palmer, LJ (1); Tiesler, CMT (1); Jaddoe, VWV (1); Wjst, M (1); Raaschou-Nielsen, O (1); show less...

University: Karolinska Institutet (4); Stockholm University (1)

Language: English (4)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

Year: 2013 (4)Undo refine

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