Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer

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Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer

Bolton, Kelly L. (author)

Chenevix-Trench, Georgia (author)

Goh, Cindy (author)

Sadetzki, Siegal (author)

Ramus, Susan J. (author)

Karlan, Beth Y. (author)

Lambrechts, Diether (author)

Despierre, Evelyn (author)

Barrowdale, Daniel (author)

McGuffog, Lesley (author)

Healey, Sue (author)

Easton, Douglas F. (author)

Sinilnikova, Olga (author)

Benitez, Javier (author)

Garcia, Maria J. (author)

Neuhausen, Susan (author)

Gail, Mitchell H. (author)

Hartge, Patricia (author)

Peock, Susan (author)

Frost, Debra (author)

Evans, Gareth (author)

Eeles, Rosalind (author)

Godwin, Andrew K. (author)

Daly, Mary B. (author)

Kwong, Ava (author)

Ma, Edmond S. K. (author)

Lazaro, Conxi (author)

Blanco, Ignacio (author)

Montagna, Marco (author)

D'Andrea, Emma (author)

Nicoletto, Maria Ornella (author)

Johnatty, Sharon E. (author)

Krueger, Susanne (author)

Jensen, Allan (author)

Hogdall, Estrid (author)

Goode, Ellen L. (author)

Fridley, Brooke L. (author)

Loud, Jennifer T. (author)

Greene, Mark H. (author)

Mai, Phuong L. (author)

Chetrit, Angela (author)

Lubin, Flora (author)

Hirsh-Yechezkel, Galit (author)

Glendon, Gord (author)

Andrulis, Irene L. (author)

Toland, Amanda E. (author)

Senter, Leigha (author)

Gore, Martin E. (author)

Gourley, Charlie (author)

Michie, Caroline O. (author)

Song, Honglin (author)

Tyrer, Jonathan (author)

Whittemore, Alice S. (author)

McGuire, Valerie (author)

Sieh, Weiva (author)

Kristoffersson, Ulf (author): Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine

Olsson, Håkan (author): Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine

Borg, Åke (author): Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine

Levine, Douglas A. (author)

Steele, Linda (author)

Beattie, Mary S. (author)

Chan, Salina (author)

Nussbaum, Robert L. (author)

Moysich, Kirsten B. (author)

Gross, Jenny (author)

Cass, Ilana (author)

Walsh, Christine (author)

Li, Andrew J. (author)

Leuchter, Ronald (author)

Gordon, Ora (author)

Garcia-Closas, Montserrat (author)

Gayther, Simon A. (author)

Chanock, Stephen J. (author)

Antoniou, Antonis C. (author)

Pharoah, Paul D. P. (author)

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(creator_code:org_t)

American Medical Association (AMA), 2012
2012
English.
In: JAMA: The Journal of the American Medical Association. - : American Medical Association (AMA). - 1538-3598. ; 307:4, s. 382-390

Related links:: http://dx.doi.org/10...; show more...; https://jamanetwork....; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear. Objective To characterize the survival of BRCA carriers with EOC compared with noncarriers and to determine whether BRCA1 and BRCA2 carriers show similar survival patterns. Design, Setting, and Participants A pooled analysis of 26 observational studies on the survival of women with ovarian cancer, which included data from 1213 EOC cases with pathogenic germline mutations in BRCA1 (n=909) or BRCA2 (n=304) and from 2666 noncarriers recruited and followed up at variable times between 1987 and 2010 (the median year of diagnosis was 1998). Main Outcome Measure Five-year overall mortality. Results The 5-year overall survival was 36% (95% CI, 34%-38%) for noncarriers, 44% (95% CI, 40%-48%) for BRCA1 carriers, and 52% (95% CI, 46%-58%) for BRCA2 carriers. After adjusting for study and year of diagnosis, BRCA1 and BRCA2 mutation carriers showed a more favorable survival than noncarriers (for BRCA1: hazard ratio [HR], 0.78; 95% CI, 0.68-0.89; P<.001; and for BRCA2: HR, 0.61; 95% CI, 0.50-0.76; P<.001). These survival differences remained after additional adjustment for stage, grade, histology, and age at diagnosis (for BRCA1: HR, 0.73; 95% CI, 0.64-0.84; P<.001; and for BRCA2: HR, 0.49; 95% CI, 0.39-0.61; P<.001). The BRCA1 HR estimate was significantly different from the HR estimated in the adjusted model (P for heterogeneity=.003). Conclusion Among patients with invasive EOC, having a germline mutation in BRCA1 or BRCA2 was associated with improved 5-year overall survival. BRCA2 carriers had the best prognosis. JAMA. 2012;307(4):382-390

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By the author/editor: Bolton, Kelly L.; Chenevix-Trench, ...; Goh, Cindy; Sadetzki, Siegal; Ramus, Susan J.; Karlan, Beth Y.; show more...; Lambrechts, Diet ...; Despierre, Evely ...; Barrowdale, Dani ...; McGuffog, Lesley; Healey, Sue; Easton, Douglas ...; Sinilnikova, Olg ...; Benitez, Javier; Garcia, Maria J.; Neuhausen, Susan; Gail, Mitchell H ...; Hartge, Patricia; Peock, Susan; Frost, Debra; Evans, Gareth; Eeles, Rosalind; Godwin, Andrew K ...; Daly, Mary B.; Kwong, Ava; Ma, Edmond S. K.; Lazaro, Conxi; Blanco, Ignacio; Montagna, Marco; D'Andrea, Emma; Nicoletto, Maria ...; Johnatty, Sharon ...; Krueger, Susanne; Jensen, Allan; Hogdall, Estrid; Goode, Ellen L.; Fridley, Brooke ...; Loud, Jennifer T ...; Greene, Mark H.; Mai, Phuong L.; Chetrit, Angela; Lubin, Flora; Hirsh-Yechezkel, ...; Glendon, Gord; Andrulis, Irene ...; Toland, Amanda E ...; Senter, Leigha; Gore, Martin E.; Gourley, Charlie; Michie, Caroline ...; Song, Honglin; Tyrer, Jonathan; Whittemore, Alic ...; McGuire, Valerie; Sieh, Weiva; Kristoffersson, ...; Olsson, Håkan; Borg, Åke; Levine, Douglas ...; Steele, Linda; Beattie, Mary S.; Chan, Salina; Nussbaum, Robert ...; Moysich, Kirsten ...; Gross, Jenny; Cass, Ilana; Walsh, Christine; Li, Andrew J.; Leuchter, Ronald; Gordon, Ora; Garcia-Closas, M ...; Gayther, Simon A ...; Chanock, Stephen ...; Antoniou, Antoni ...; Pharoah, Paul D. ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

Articles in the publication: JAMA: The Journa ...; JAMA

By the university: Lund University

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Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer

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