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Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Takeuchi, Fumihiko (author)
Akiyama, Masato (author)
Matoba, Nana (author)
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Katsuya, Tomohiro (author)
Nakatochi, Masahiro (author)
Tabara, Yasuharu (author)
Narita, Akira (author)
Saw, Woei-Yuh (author)
Moon, Sanghoon (author)
Spracklen, Cassandra N. (author)
Chai, Jin-Fang (author)
Kim, Young-Jin (author)
Zhang, Liang (author)
Wang, Chaolong (author)
Li, Huaixing (author)
Li, Honglan (author)
Wu, Jer-Yuarn (author)
Dorajoo, Rajkumar (author)
Nierenberg, Jovia L. (author)
Wang, Ya Xing (author)
He, Jing (author)
Bennett, Derrick A. (author)
Takahashi, Atsushi (author)
Momozawa, Yukihide (author)
Hirata, Makoto (author)
Matsuda, Koichi (author)
Rakugi, Hiromi (author)
Nakashima, Eitaro (author)
Isono, Masato (author)
Shirota, Matsuyuki (author)
Hozawa, Atsushi (author)
Ichihara, Sahoko (author)
Matsubara, Tatsuaki (author)
Yamamoto, Ken (author)
Kohara, Katsuhiko (author)
Igase, Michiya (author)
Han, Sohee (author)
Gordon-Larsen, Penny (author)
Huang, Wei (author)
Lee, Nanette R. (author)
Adair, Linda S. (author)
Hwang, Mi Yeong (author)
Lee, Juyoung (author)
Chee, Miao Li (author)
Sabanayagam, Charumathi (author)
Zhao, Wanting (author)
Liu, Jianjun (author)
Reilly, Dermot F. (author)
Sun, Liang (author)
Huo, Shaofeng (author)
Edwards, Todd L. (author)
Long, Jirong (author)
Chang, Li-Ching (author)
Chen, Chien-Hsiun (author)
Yuan, Jian-Min (author)
Koh, Woon-Puay (author)
Friedlander, Yechiel (author)
Kelly, Tanika N. (author)
Bin Wei, Wen (author)
Xu, Liang (author)
Cai, Hui (author)
Xiang, Yong-Bing (author)
Lin, Kuang (author)
Clarke, Robert (author)
Walters, Robin G. (author)
Millwood, Iona Y. (author)
Li, Liming (author)
Chambers, John C. (author)
Kooner, Jaspal S. (author)
Elliott, Paul (author)
van der Harst, Pim (author)
Chen, Zhengming (author)
Sasaki, Makoto (author)
Shu, Xiao-Ou (author)
Jonas, Jost B. (author)
He, Jiang (author)
Heng, Chew-Kiat (author)
Chen, Yuan-Tsong (author)
Zheng, Wei (author)
Lin, Xu (author)
Teo, Yik-Ying (author)
Tai, E-Shyong (author)
Cheng, Ching-Yu (author)
Wong, Tien Yin (author)
Sim, Xueling (author)
Mohlke, Karen L. (author)
Yamamoto, Masayuki (author)
Kim, Bong-Jo (author)
Miki, Tetsuro (author)
Nabika, Toru (author)
Yokota, Mitsuhiro (author)
Kamatani, Yoichiro (author)
Kubo, Michiaki (author)
Kato, Norihiro (author)
Rolandsson, Olov (contributor)
Umeå universitet,Allmänmedicin,The International Genomics of Blood Pressure (iGEN-BP) Consortium
Franks, Paul W. (contributor)
Umeå universitet,Allmänmedicin,The International Genomics of Blood Pressure (iGEN-BP) Consortium; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, USA
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 (creator_code:org_t)
2018-11-28
2018
English.
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 9:1
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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art (subject category)

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By the author/editor
Takeuchi, Fumihi ...
Akiyama, Masato
Matoba, Nana
Katsuya, Tomohir ...
Nakatochi, Masah ...
Tabara, Yasuharu
show more...
Narita, Akira
Saw, Woei-Yuh
Moon, Sanghoon
Spracklen, Cassa ...
Chai, Jin-Fang
Kim, Young-Jin
Zhang, Liang
Wang, Chaolong
Li, Huaixing
Li, Honglan
Wu, Jer-Yuarn
Dorajoo, Rajkuma ...
Nierenberg, Jovi ...
Wang, Ya Xing
He, Jing
Bennett, Derrick ...
Takahashi, Atsus ...
Momozawa, Yukihi ...
Hirata, Makoto
Matsuda, Koichi
Rakugi, Hiromi
Nakashima, Eitar ...
Isono, Masato
Shirota, Matsuyu ...
Hozawa, Atsushi
Ichihara, Sahoko
Matsubara, Tatsu ...
Yamamoto, Ken
Kohara, Katsuhik ...
Igase, Michiya
Han, Sohee
Gordon-Larsen, P ...
Huang, Wei
Lee, Nanette R.
Adair, Linda S.
Hwang, Mi Yeong
Lee, Juyoung
Chee, Miao Li
Sabanayagam, Cha ...
Zhao, Wanting
Liu, Jianjun
Reilly, Dermot F ...
Sun, Liang
Huo, Shaofeng
Edwards, Todd L.
Long, Jirong
Chang, Li-Ching
Chen, Chien-Hsiu ...
Yuan, Jian-Min
Koh, Woon-Puay
Friedlander, Yec ...
Kelly, Tanika N.
Bin Wei, Wen
Xu, Liang
Cai, Hui
Xiang, Yong-Bing
Lin, Kuang
Clarke, Robert
Walters, Robin G ...
Millwood, Iona Y ...
Li, Liming
Chambers, John C ...
Kooner, Jaspal S ...
Elliott, Paul
van der Harst, P ...
Chen, Zhengming
Sasaki, Makoto
Shu, Xiao-Ou
Jonas, Jost B.
He, Jiang
Heng, Chew-Kiat
Chen, Yuan-Tsong
Zheng, Wei
Lin, Xu
Teo, Yik-Ying
Tai, E-Shyong
Cheng, Ching-Yu
Wong, Tien Yin
Sim, Xueling
Mohlke, Karen L.
Yamamoto, Masayu ...
Kim, Bong-Jo
Miki, Tetsuro
Nabika, Toru
Yokota, Mitsuhir ...
Kamatani, Yoichi ...
Kubo, Michiaki
Kato, Norihiro
Rolandsson, Olov
Franks, Paul W.
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Nature Communica ...
By the university
Umeå University

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