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Blood Metabolic Signatures of Body Mass Index : A Targeted Metabolomics Study in the EPIC Cohort

Carayol, Marion (author)
International Agency for Research on Cancer, World Health Organization
Leitzmann, Michael F. (author)
International Agency for Research on Cancer, World Health Organization
Ferrari, Pietro (author)
International Agency for Research on Cancer, World Health Organization
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Zamora-Ros, Raul (author)
International Agency for Research on Cancer, World Health Organization
Achaintre, David (author)
International Agency for Research on Cancer, World Health Organization
Stepien, Magdalena (author)
International Agency for Research on Cancer, World Health Organization
Schmidt, Julie A (author)
University of Oxford
Travis, Ruth C (author)
University of Oxford
Overvad, Kim (author)
Aarhus University
Tjønneland, Anne (author)
Danish Cancer Society
Hansen, Louise (author)
Danish Cancer Society
Kaaks, Rudolf (author)
German Cancer Research Centre
Kühn, Tilman (author)
German Cancer Research Centre
Boeing, Heiner (author)
German Institute of Human Nutrition
Bachlechner, Ursula (author)
German Institute of Human Nutrition
Trichopoulou, Antonia (author)
Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens,Harvard University
Bamia, Christina (author)
Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
Palli, Domenico (author)
Cancer Research and Prevention Institute (ISPO)
Agnoli, Claudia (author)
Istituto Nazionale dei Tumori
Tumino, Rosario (author)
Civic and M.P Arezzo Hospital
Vineis, Paolo (author)
Imperial College London
Panico, Salvatore (author)
University of Naples Federico II
Quirós, J Ramón (author)
Public Health Directorate
Sánchez-Cantalejo, Emilio (author)
Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
Huerta, José María (author)
CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
Ardanaz, Eva (author)
CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
Arriola, Larraitz (author)
CIBER Epidemiology and Public Health (CIBERESP)
Agudo, Antonio (author)
Catalan Institute of Oncology
Nilsson, Jan (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Bueno de Mesquita, Bas (author)
National Institute for Public Health and the Environment (RIVM),Imperial College London,University of Malaya,University Medical Center Utrecht
Peeters, Petra H. (author)
Imperial College London,University Medical Center Utrecht
Wareham, Nick (author)
University of Cambridge
Khaw, Kay-Tee (author)
University of Cambridge
Jenab, Mazda (author)
International Agency for Research on Cancer, World Health Organization
Key, Timothy J (author)
University of Oxford
Scalbert, Augustin (author)
International Agency for Research on Cancer, World Health Organization
Rinaldi, Sabina (author)
International Agency for Research on Cancer, World Health Organization
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 (creator_code:org_t)
2017-08-11
2017
English 10 s.
In: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 16:9, s. 3137-3146
Related links:
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

blood
body mass index
metabolic profiling
obesity
targeted metabolome

Publication and Content Type

art (subject category)
ref (subject category)

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