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Sökning: WFRF:(Lekander M) > (2015-2019)

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  • O'Toole, M. S., et al. (författare)
  • Effects of psychological interventions on systemic levels of inflammatory biomarkers in humans : A systematic review and meta-analysis
  • 2018
  • Ingår i: Brain, behavior, and immunity. - : Elsevier BV. - 0889-1591 .- 1090-2139. ; 74, s. 68-78
  • Forskningsöversikt (refereegranskat)abstract
    • The purpose of the present investigation was to systematically review randomized controlled trials examining the effects of psychological interventions on inflammatory biomarkers in adult populations and to quantitatively analyze those effects by meta-analysis. Two researchers independently searched key electronic databases, selected eligible publications, extracted data, and evaluated methodological quality. Nineteen randomized controlled trials examining a total of 1510 participants were included. The overall combined effect size from pre to post psychological intervention on pro-inflammatory biomarker levels was statistically significant, showing an attenuating effect, although of a small magnitude (s’ g = 0.15, p = .008, CI [0.04–0.26]). However, this effect was not maintained into the follow-up period (g < −0.01, p = .964, CI [−0.19–0.18]). Looking at the individual biomarkers assessed across studies, only C-reactive protein (CRP) was found to significantly decrease following psychological intervention. A number of moderation analyses were conducted, none of which reached statistical significance. However, the numerically largest – and significant – within-group effect size was obtained for the group of studies that had preselected participants based on elevated psychological distress (g = 0.29, p = .047). In conclusion, psychological interventions appear efficacious in reducing pro-inflammatory biomarker levels. Future studies are recommended to carefully select individuals based on inflammatory (e.g., the presence of low-grade inflammation) and/or psychological (e.g., psychological distress) criteria.
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  • Regenbogen, C, et al. (författare)
  • Multisensory detection of sickness
  • 2017
  • Ingår i: CHEMICAL SENSES. - 0379-864X. ; 42:2, s. E47-E48
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Regenbogen, C, et al. (författare)
  • Multisensory Detection of Sickness
  • 2018
  • Ingår i: CHEMICAL SENSES. - 0379-864X. ; 43:4, s. E70-E70
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Regenbogen, C., et al. (författare)
  • Multisensory detection of sickness
  • 2016
  • Ingår i: XXVIth Annual Meeting of the European Chemoreception Research Organization. ; , s. 94-95
  • Konferensbidrag (refereegranskat)abstract
    • Converging evidence suggests that humans have a behavioral repertoire that assists the immune system in the defense against infectious disease. Behavioral detection of subtle and early sickness cues in others, and subsequent avoidance of the infected conspecific, would indeed be a cost-efficient way of coping with an environment fraught with pathogens. That humans can detect early and subtle cues of sickness by way of both olfaction and vision was recently demonstrated. The current study targeted how sickness cues affect social perception 95and how these visual and olfactory cues, alone and in unison, activate the brain.
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