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- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 7. |
- Li, Wenya, et al.
(författare)
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Upper-Hybrid Waves Driven by Meandering Electrons Around Magnetic Reconnection X Line
- 2021
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Ingår i: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 48:16
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Tidskriftsartikel (refereegranskat)abstract
- Magnetic reconnection is a fundamental process in collisionless space plasma environment, and plasma waves relevant to the kinetic interactions can have a significant impact on the multiscale behavior of reconnection. Here, we present Magnetospheric Multiscale (MMS) observations during an encounter of an X line of symmetric magnetic reconnection in the magnetotail. The X line is characterized by reversals of ion and electron jets and electromagnetic fields, agyrotropic electron velocity distribution functions (VDFs), and an electron-scale current sheet. MMS observe large-amplitude nonlinear upper-hybrid (UH) waves on both sides of the neutral line, and the wave amplitudes have highly localized distribution along the normal direction. The inbound meandering electrons drive the UH waves, releasing the free energy stored from the reconnection electric field along the meandering trajectories. The interaction between the meandering electrons and the UH waves may modify the balance of the reconnection electric field around the X line. Plain Language Summary The electron-scale kinetic physics in the electron diffusion region (EDR) controls how magnetic field lines break and reconnect. Electron crescent, an indicator of EDR, can drive high-frequency electrostatic waves around EDR. For the first time, the upper-hybrid (UH) waves are observed on both sides of the X line and we show the direct association between the UH waves and the reconnection electric field. The strong wave-electron interaction can change the electron-scale dynamics and may modify the reconnection electric field. This study demonstrates that the UH waves may play an important role in controlling the reconnection rate.
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| 9. |
- Qiao, Mengyao, et al.
(författare)
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60 Gbit/s PAM-4 wireless transmission in the 310 GHz band with nonlinearity tolerant signal processing
- 2021
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Ingår i: Optics Communications. - : Elsevier BV. - 0030-4018 .- 1873-0310. ; 492
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Tidskriftsartikel (refereegranskat)abstract
- We experimentally demonstrate a terahertz (THz) photonic wireless transmission system in the 310 GHz band with four-level pulse amplitude modulation (PAM-4) signals. A zero-bias diode is used as a simple direct detection receiver, which is cost-effective compared to a conventional coherent receiver. Moreover, we comprehensively investigate the system performance by applying linear and nonlinear equalization schemes. The experimental results show that Volterra nonlinear filtering can significantly improve the system capacity by around 90%, and transmissions of up to 60 Gbit/s PAM-4 signals over a 3 m wireless link are successfully achieved. The advantageous features of this make it promising for high-speed THz wireless communications.
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