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- Zhang, Weihua, et al.
(författare)
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Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels.
- 2016
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Ingår i: Thrombosis and haemostasis. - 2567-689X. ; 116:6, s. 1041-1049
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Tidskriftsartikel (refereegranskat)abstract
- ). Together these two loci explain 7 % of the total variance in serum L-arginine concentrations. The associations at both loci were replicated in independent cohorts with plasma L-arginine measurements (p<0.004). The two sentinel SNPs are in nearly complete LD with the nonsynonymous SNP rs3733402 at KLKB1 and the 5'-UTR SNP rs1801020 at F12, respectively. SNPs at both loci are associated with blood pressure. Our findings provide new insight into the genetic regulation of L-arginine and its potential relationship with cardiovascular risk.
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