| 1. |
- Björkqvist, Maria, et al.
(author)
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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.
- 2008
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In: Journal of Experimental Medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 205, s. 1869-1877
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Journal article (peer-reviewed)abstract
- Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. We examined the peripheral immune system and found widespread evidence of innate immune activation detectable in plasma throughout the course of HD. Interleukin 6 levels were increased in HD gene carriers with a mean of 16 years before the predicted onset of clinical symptoms. To our knowledge, this is the earliest plasma abnormality identified in HD. Monocytes from HD subjects expressed mutant huntingtin and were pathologically hyperactive in response to stimulation, suggesting that the mutant protein triggers a cell-autonomous immune activation. A similar pattern was seen in macrophages and microglia from HD mouse models, and the cerebrospinal fluid and striatum of HD patients exhibited abnormal immune activation, suggesting that immune dysfunction plays a role in brain pathology. Collectively, our data suggest parallel central nervous system and peripheral pathogenic pathways of immune activation in HD.
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| 2. |
- Möller, Niels, et al.
(author)
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Supporting end-to-end applications over HSDPA by cross-layer signalling
- 2007
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In: IEEE WIRELESS COMMUNICATIONS & NETWORKING CONFERENCE, VOLS 1-9. - NEW YORK : IEEE. - 9781424406586 ; , s. 3858-3863
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Conference paper (peer-reviewed)abstract
- A new control structure is proposed to improve user experience of wireless Internet. Information on radio bandwidth and queue length available in the radio network, close to the base station, is used in a proxy that resides between the Internet and the cellular system. The control algorithm in the proxy sets the window size according to event-triggered information on radio bandwidth changes and time-triggered information on the queue length at the wireless link. The mechanism is compared to TCP Reno in two simulation scenarios. The first scenario models a dedicated channel with stepwise changes in the bandwidth, while the second scenario models the High-speed Downlink Shared Channel recently introduced by 3GPP. The proposed mechanism significantly reduces the amount of buffer space needed in the radio network, and it also gives modest improvements to user response time and link utilization. Reduced buffering is particularly beneficial for third-party end-to-end real-time services such as voice, video, and online gaming.
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| 3. |
- Möller, Patrik
(author)
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Glimten i läkarens blick : Foucault, psykiatrihistoria och "antropologiska kategorier"
- 2006
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In: Scandia. - : Lunds universitet. - 0036-5483. ; 72:2, s. 60-70
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Journal article (peer-reviewed)abstract
- In The Archaeology of Knowledge Michel Foucault teaches us to discard or at least decentre the historical subject and to call all the unquestioned continuities by which we organize the discourses we want to analyse in question. The aim of this study is to discuss the implications of such a theoretical approach when it is applied to a scholarly project that focuses on a certain historical individual, the Swedish psychiatrist, Bror Gadelius, and his role in the formation of a specific discursive formation, early 20th-century psychiatry in Sweden.
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| 4. |
- Möller, Patrik, 1966
(author)
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Myten om Darwin: Om myters uppkomst genom onaturligt urval
- 2006
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In: I skuggan av samtiden: En vänbok till Sven-Eric Liedman och Amanda Peralta, Johan Kärnfelt (red.). - Göteborg : Göteborg University. - 9197623903 ; , s. 347-366
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Book chapter (other academic/artistic)
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| 7. |
- Novac, Bucur M., et al.
(author)
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A 10-GW pulsed power supply for HPM sources
- 2006
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In: IEEE TRANS PLASMA SCI. ; , s. 1814-1821
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Conference paper (peer-reviewed)abstract
- A research activity involving the detailed consideration of novel high-voltage transformers for pulsed-power applications has recently begun at Loughborough University. Although the main goal is the demonstration of a compact and lightweight unit employing magnetic insulation under vacuum conditions, the initial stage of the work is directed toward the development of a conventional air-cored transformer as a main component in a compact power supply for high power microwave sources. In cooperation with the Swedish Defence Research Agency (FOI), the power supply has been tested with a microwave source of the vircator type. The power generator for the system uses a 70-kJ/25-kV capacitor bank and an exploding wire array to generate a 150-kV voltage pulse in the primary circuit of a transformer. A pressurized SF6 spark gap in the secondary circuit sharpens the high-voltage output so that pulses approaching 500 kV and with a rise time well below 100 ns are generated on a 20-Omega high-power resistors With the peak power in excess of 10 GW. Experimental results are presented from final testing of the system, where a reflex triode vircator replaces the 20-Omega resistor. Measurements of the microwave emission using free-field sensors are presented, and comments are made with the microwave emission from the same vircator when powered by a Marx generator at FOI.
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