| 1. |
- Ahlström, Håkan, et al.
(författare)
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Positron emission tomography in the diagnosis and staging of urinary bladder cancer
- 1996
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Ingår i: Acta Radiologica. - 0284-1851 .- 1600-0455. ; 37:2, s. 180-185
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Evaluation of positron emission tomography (PET) using (18)fl 18F-2-fluoro-2-deoxy-D-glucose (18FDG) and L-methyl-11C-methionine in the diagnosis and staging of urinary bladder carcinoma. MATERIAL AND METHODS: Twenty-three patients with biopsy-proven urinary bladder carcinoma were examined with PET after intravenous injection of 11C-methionine; 2 were also examined with 18FDG. The results from the PET investigations were compared with CT or MR findings and TNM classification before and after treatment. RESULTS: The urinary excretion of 18FDG prevented distinction of the primary tumour from the surrounding tracer. With 11C-methionine it was possible to detect 18/23 primary tumours. A trend was seen, suggesting that the higher the uptake values of 11C-methionine in the tumour, the greater the tumour stage. CONCLUSION: It is possible to visualize urinary bladder tumours larger than 1 cm in diameter with PET using (11)C-methionine, but the value of the method in the staging of the lesions is not superior to conventional methods.
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| 2. |
- Carlsson, Jörgen, et al.
(författare)
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Conjugate chemistry and cellular processing of EGF-dextran
- 1999
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Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 38:3, s. 313-321
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Tidskriftsartikel (refereegranskat)abstract
- Conjugates with specific binding to the epidermal growth factor receptor, EGFR, of interest for radionuclide based imaging and therapy were prepared using mouse epidermal growth factor, mEGF, and dextran. In one type of conjugate, mEGF was coupled to dextran by reductive amination in which the free amino group on the mEGF N-terminal reacted with the aldehyde group on the reductive end of dextran. The end-end coupled conjugate could be further activated by the cyanopyridinium agent CDAP, thereby introducing tyrosines to the dextran part. In the other type of conjugate, the cyanylating procedure using CDAP was applied, first to activate dextran and then allowing for the amino terminus of mEGF to randomly attach to the dextran. In the latter case, radionuclide-labelled tyrosines or glycines could be added in the same conjugation step. All types of mEGF-dextran conjugates had EGFR-specific binding since the binding could be displaced by an excess of non-radioactive mEGF. The conjugates were to a large extent internalized in the test cells and the associated radioactivity was retained intracellularly for different times depending on both the type of cells and conjugate applied. Different intracellular 'traffic routes' for the radionuclides are discussed as well as applications for both imaging and therapy.
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| 3. |
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| 4. |
- Jarkrans, Torsten, et al.
(författare)
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Grading of transitional cell bladder carcinoma by image analysis of histological sections
- 1995
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Ingår i: Analytical Cellular Pathology. - : ELSEVIER SCI PUBL IRELAND LTD. - 0921-8912 .- 1878-3651. ; 8:2, s. 135-158
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Tidskriftsartikel (refereegranskat)abstract
- Image analysis of histological sections was used to achieve a more objective malignancy grading of transitional cell carcinoma of the bladder. Images from Feulgen-stained sections from a clinical material of 197 tumours were analyzed. Features at various
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| 5. |
- Ranefall, Petter, et al.
(författare)
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Automatic quantification of microvessels using unsupervised image analysis
- 1998
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Ingår i: Analytical Cellular Pathology. - : IOS PRESS. - 0921-8912 .- 1878-3651. ; 17:2, s. 83-92
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Tidskriftsartikel (refereegranskat)abstract
- An automatic method for quantification of images of microvessels by computing area proportions and number of objects is presented. The objects are segmented from the background using dynamic thresholding of the average component size histogram. To be able
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| 6. |
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| 7. |
- Wester, Kenneth, et al.
(författare)
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Automatic quantification of microvessel density in urinary bladder carcinoma
- 1999
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Ingår i: British Journal of Cancer. - : CHURCHILL LIVINGSTONE. - 0007-0920 .- 1532-1827. ; 81:8, s. 1363-1370
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Tidskriftsartikel (refereegranskat)abstract
- Seventy-three TUR-T biopsies from bladder carcinoma were evaluated regarding microvessel density, defined as microvessel number (nMVD) and cross-section endothelial cell area (aMVD). A semi-automatic and a newly developed, automatic image analysis techniq
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