| 1. |
- Claesson, Maria, 1985, et al.
(author)
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Improved QCM-D signal-to-noise ratio using mesoporous silica and titania
- 2012
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In: Sensors and Actuators, B: Chemical. - : Elsevier BV. - 0925-4005. ; 166, s. 526-534
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Journal article (peer-reviewed)abstract
- In many biological and environmental applications it is crucial to detect low concentrations of low molecular weight analytes. To accomplish this a variety of surface sensing techniques, such as quartz crystal microbalance with dissipation monitoring (QCM-D) and surface plasmon resonance (SPR), have been developed. These techniques provide good sensitivity and selectivity, however, there is a need to improve these even further by enhancing the signal-to-noise ratio. One suggestion to improve the QCM-D signal is to use mesoporous coated QCM-D sensor crystals as sensing substrate. Mesoporous materials are promising to use, since they possess a high specific surface area and that their properties, such as pore size, pore geometry and surface chemistry, can be controlled. Here we demonstrate a method to increase the signal-to-noise ratio of the QCM-D signal illustrated by adsorbing dendrimers on mesoporous silica and titania coated QCM-D crystals. The experiments were performed on cubic mesoporous silica having varying pore sizes and hexagonal and cubic mesoporous titania having similar pore size. The results showed that the QCM-D signal-to-noise was improved when mesoporous material was used and that the pore size and pore geometry determined the selectivity of the adsorbing analyte. These findings are important in the detection of analytes at low concentrations using QCM-D.
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| 2. |
- Karlsson, Johan, 1984, et al.
(author)
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In vivo biomechanical stability of osseointegrating mesoporous TiO2 implants
- 2012
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In: Acta Biomaterialia. - : Elsevier BV. - 1878-7568 .- 1742-7061. ; 8:12, s. 4438-4446
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Journal article (peer-reviewed)abstract
- Mesoporous materials are of high interest as implant coatings to receive an enhanced osseointegration. In this study, titanium implants coated with mesoporous TiO(2) thin films have been evaluated both in vitro and in vivo. Material characterization showed that, with partly crystalline TiO(2) (anatase), long-range-ordered hydrophilic mesoporous thin films with a pore size of 6nm were obtained. Evaluation of the mechanical resistance showed that the films were robust enough to withstand the standard implantation procedure. In vitro apatite formation was studied using simulated body fluids, showing that the pores are accessible for ions and that formation of apatite was increased due to the presence of the mesopores. An in vivo study using a rabbit model was executed in which the removal torque and histomorphometry were evaluated. The results show that the biomechanical stability of the TiO(2) coating was unaffected by the presence of mesopores and that osseointegration was achieved without any signs of inflammation.
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