| 1. |
|
|
| 2. |
- Tao, Bairui, et al.
(författare)
-
Three-dimensional graphene nanosheets supported by NiO/Si-MCP as electrode materials for high-performance supercapacitors
- 2017
-
Ingår i: Ionics (Kiel). - : Springer Science and Business Media LLC. - 0947-7047 .- 1862-0760. ; 23:8, s. 2185-2191
-
Tidskriftsartikel (refereegranskat)abstract
- A three-dimensional (3D) graphene/NiO/Si-microchannel (MCP) composite electrode is synthesized by the conventional microelectronic machining process and electrochemical exfoliation technology for electrochemical capacitors. SEM, AFM, and Raman scattering are used to investigate the morphology and structure, and electrochemical characterization reveals that the 3D graphene/NiO/Si-MCP has a high specific capacitance of 833 Fg-1 at a current density of 5 Ag-1 in 6 mol L-1 KOH. Moreover, good cycling performance with 92% capacitance retention after 1000 cycles is observed indicating the novel electrode has large potential in high-performance supercapacitors.
|
|
| 3. |
- Wuttke, Matthias, et al.
(författare)
-
A catalog of genetic loci associated with kidney function from analyses of a million individuals
- 2019
-
Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 51:6, s. 957-972
-
Tidskriftsartikel (refereegranskat)abstract
- Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
|
|
| 4. |
- Ho, Peh Joo, et al.
(författare)
-
Comparison of self-reported and register-based hospital medical data on comorbidities in women
- 2019
-
Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 9:1
-
Tidskriftsartikel (refereegranskat)abstract
- Breast cancer patients commonly present with comorbidities which are known to influence treatment decisions and survival. We aim to examine agreement between self-reported and register-based medical records (National Patient Register [NPR]). Ascertainment of nine conditions, using individually-linked data from 64,961 women enrolled in the Swedish KARolinska MAmmography Project for Risk Prediction of Breast Cancer (KARMA) study. Agreement was assessed using observed proportion of agreement (overall agreement), expected proportion of agreement, and Cohen's Kappa statistic. Two-stage logistic regression models taking into account chance agreement were used to identify potential predictors of overall agreement. High levels of overall agreement (i.e. ≥86.6%) were observed for all conditions. Substantial agreement (Cohen's Kappa) was observed for myocardial infarction (0.74), diabetes (0.71) and stroke (0.64) between self-reported and NPR data. Moderate agreement was observed for preeclampsia (0.51) and hypertension (0.46). Fair agreement was observed for heart failure (0.40) and polycystic ovaries or ovarian cysts (0.27). For hyperlipidemia (0.14) and angina (0.10), slight agreement was observed. In most subgroups we observed negative specific agreement of >90%. There is no clear reference data source for ascertainment of conditions. Negative specific agreement between NPR and self-reported data is consistently high across all conditions.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Takeuchi, Fumihiko, et al.
(författare)
-
Interethnic analyses of blood pressure loci in populations of East Asian and European descent
- 2018
-
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 9:1
-
Tidskriftsartikel (refereegranskat)abstract
- Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
|
|
| 8. |
- Zhang, Shang-Zhou, et al.
(författare)
-
First-principles study of phase stability and elastic properties of binary Ti-xTM (TM = V,Cr,Nb,Mo) and ternary Ti-15TH-yAl alloys
- 2016
-
Ingår i: Materials & design. - : Elsevier. - 0264-1275 .- 1873-4197. ; 110, s. 80-89
-
Tidskriftsartikel (refereegranskat)abstract
- The phase stability and elastic property of binary Ti-chi TM (TM=V, Cr, Nb, Mo) and ternary Ti-15TH-yAl alloys are investigated systematically by using a first-principles method. The coherent potential approximation is employed to describe the random distribution of the alloying atoms in the alloys. We show that the transition metal (TM) elements V, Cr, Nb, Mo increase the elastic stability of the beta phase but decreases that of the a phase. The polycrystalline bulk modulus of the a phase increases with the concentration of the TM alloying elements whereas the Young's modulus and shear modulus are weakened. For the beta phase, all the polycrystalline elastic moduli hardens with the addition of the TM alloying elements. The influence of the simple metal (SM) element Al on the elastic properties is much weaker than the TM ones. The TM alloying elements increase the stability of the beta relative to the alpha and omega phases. Al stabilizes significantly the beta phase over the omega phase. Our calculations suggest that the d electron density dominates the elastic modulus but not the relative phase stability. The interaction between the TM and SM alloying elements in titanium alloys matters to the relative stability.
|
|
