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Träfflista för sökning "WFRF:(Michael Agnieszka) srt2:(2007-2009)"

Sökning: WFRF:(Michael Agnieszka) > (2007-2009)

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1.
  • Juncker, Agnieszka S, et al. (författare)
  • Sequence-based feature prediction and annotation of proteins
  • 2009
  • Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1465-6914 .- 1465-6906. ; 10:2, s. 206-
  • Tidskriftsartikel (refereegranskat)abstract
    • A recent trend in computational methods for annotation of protein function is that many prediction tools are combined in complex workflows and pipelines to facilitate the analysis of feature combinations, for example, the entire repertoire of kinase-binding motifs in the human proteome.
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4.
  • van Es, Michael A, et al. (författare)
  • Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis
  • 2009
  • Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:10, s. 1083-1087
  • Tidskriftsartikel (refereegranskat)abstract
    • We conducted a genome-wide association study among 2,323 individuals with sporadic amyotrophic lateral sclerosis (ALS) and 9,013 control subjects and evaluated all SNPs with P < 1.0 x 10(-4) in a second, independent cohort of 2,532 affected individuals and 5,940 controls. Analysis of the genome-wide data revealed genome-wide significance for one SNP, rs12608932, with P = 1.30 x 10(-9). This SNP showed robust replication in the second cohort (P = 1.86 x 10(-6)), and a combined analysis over the two stages yielded P = 2.53 x 10(-14). The rs12608932 SNP is located at 19p13.3 and maps to a haplotype block within the boundaries of UNC13A, which regulates the release of neurotransmitters such as glutamate at neuromuscular synapses. Follow-up of additional SNPs showed genome-wide significance for two further SNPs (rs2814707, with P = 7.45 x 10(-9), and rs3849942, with P = 1.01 x 10(-8)) in the combined analysis of both stages. These SNPs are located at chromosome 9p21.2, in a linkage region for familial ALS with frontotemporal dementia found previously in several large pedigrees.
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5.
  • Wykowska, Agnieszka, et al. (författare)
  • How humans optimize their interaction with the environment : The impact of action context on human perception
  • 2009
  • Ingår i: Communications in Computer and Information Science. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1865-0929 .- 1865-0937. ; 44, s. 162-172
  • Tidskriftsartikel (refereegranskat)abstract
    • Humans have developed various mechanisms to optimize interaction with the environment. Optimization of action planning requires efficient selection of action-relevant features. Selection might also depend on the environmental context in which an action takes place. The present study investigated how action context influences perceptual processing in action planning. The experimental paradigm comprised two independent tasks: (1) a perceptual visual search task and (2) a grasping or a pointing movement. Reaction times in the visual search task were measured as a function of the movement type (grasping vs. pointing) and context complexity (context varying along one dimension vs. context varying along two dimensions). Results showed that action context influenced reaction times, which suggests a close bidirectional link between action and perception as well as an impact of environmental action context on perceptual selection in the course of action planning. Such findings are discussed in the context of application for robotics
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  • Resultat 1-5 av 5

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