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CENP-F expression i...
CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer
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O'Brien, Sallyarm L. (författare)
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Fagan, Ailis (författare)
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Fox, Edward J. P. (författare)
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Millikan, Robert C. (författare)
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Culhane, Aedin C. (författare)
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Brennan, Donal J. (författare)
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McCann, Amanda H. (författare)
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Hegarty, Shauna (författare)
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Moyna, Siobhan (författare)
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Duffy, Michael J. (författare)
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HigginS, Desmond G. (författare)
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- Jirström, Karin (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Landberg, Göran (författare)
- Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups
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Gallagher, William M. (författare)
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(creator_code:org_t)
- 2007-01-04
- 2007
- Engelska.
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136. ; 120:7, s. 1434-1443
- Relaterad länk:
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- DNA microarrays have the potential to classify tumors according to their transcriptome. Tissue microarrays (TMAs) facilitate the validation of biomarkers by offering a high-throughput approach to sample analysis. We reanalyzed a high profile breast cancer DNA microarray dataset containing 96 tumor samples using a powerful statistical approach, between group analyses. Among the genes we identified was centromere protein-F (CENP-F), a gene associated with poor prognosis. In a published follow-up breast cancer DNA microarray study, comprising 295 tumour samples, we found that CENP-F upregulation was significantly associated with worse overall survival (p < 0.001) and reduced metastasis-free survival (p < 0.001). To validate and expand upon these findings, we used 2 independent breast cancer patient cohorts represented on TMAs. CENP-F protein expression was evaluated by immunohistochemistry in 91 primary breast cancer samples from cohort I and 289 samples from cohort II. CENP-F correlated with markers of aggressive tumor behavior including ER negativity and high tumor grade. In cohort I, CENP-F was significantly associated with markers of CIN including cyclin E, increased telomerase activity, c-Myc amplification and aneuploidy. In cohort II CENP-F correlated with VEGFR2, phosphorylated Ets-2 and Ki67, and in multivariate analysis, was an independent predictor of worse breast cancer-specific survival (p = 0.036) and overall survival (p = 0.040). In conclusion, we identified CENP-F as a biomarker associated with poor outcome in breast cancer and showed several novel associations of biological significance. (c) 2007 Wiley-Liss, Inc.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- CENP-F
- prognosis
- tissue microarrays
- breast cancer
- DNA microarrays
- chromosomal instability
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O'Brien, Sallyar ...
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Fagan, Ailis
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Fox, Edward J. P ...
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Millikan, Robert ...
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Culhane, Aedin C ...
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Brennan, Donal J ...
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visa fler...
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McCann, Amanda H ...
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Hegarty, Shauna
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Moyna, Siobhan
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Duffy, Michael J ...
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HigginS, Desmond ...
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Jirström, Karin
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Landberg, Göran
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Gallagher, Willi ...
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visa färre...
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