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Multimodal analysis...
Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus
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- Luikku, Antti J. (author)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurosurg Neuro Ctr, POB 100, FIN-70029 Kuopio, Finland.
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- Hall, Anette (author)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.
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- Nerg, Ossi (author)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland.
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- Koivisto, Anne M. (author)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland.
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- Hiltunen, Mikko (author)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Univ Eastern Finland, Inst Biomed, Kuopio, Finland.
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- Helisalmi, Seppo (author)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.
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- Herukka, Sanna-Kaisa (author)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland.
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- Sutela, Anna (author)
- Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland.
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- Kojoukhova, Maria (author)
- Kuopio Univ Hosp, Neurosurg Neuro Ctr, POB 100, FIN-70029 Kuopio, Finland.;Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland.
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- Mattila, Jussi (author)
- VTT Tech Res Ctr Finland, Tampere, Finland.;Combinostics Ltd, Tampere, Finland.
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- Lotjonen, Jyrki (author)
- VTT Tech Res Ctr Finland, Tampere, Finland.;Combinostics Ltd, Tampere, Finland.
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- Rummukainen, Jaana (author)
- Kuopio Univ Hosp, Dept Pathol, Kuopio, Finland.
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- Alafuzoff, Irina (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Univ Uppsala Hosp, Dept Pathol & Cytol, Uppsala, Sweden.
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- Jaaskelainen, Juha E. (author)
- Kuopio Univ Hosp, Neurosurg Neuro Ctr, POB 100, FIN-70029 Kuopio, Finland.
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- Remes, Anne M. (author)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland.
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- Soininen, Hilkka (author)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland.
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- Leinonen, Ville (author)
- Kuopio Univ Hosp, Neurosurg Neuro Ctr, POB 100, FIN-70029 Kuopio, Finland.
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Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland;Kuopio Univ Hosp, Neurosurg Neuro Ctr, POB 100, FIN-70029 Kuopio, Finland. Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland. (creator_code:org_t)
- 2016-10-14
- 2016
- English.
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In: Acta Neurochirurgica. - : Springer Science and Business Media LLC. - 0001-6268 .- 0942-0940. ; 158:12, s. 2311-2319
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Optimal selection of idiopathic normal pressure hydrocephalus (iNPH) patients for shunt surgery is challenging. Disease State Index (DSI) is a statistical method that merges multimodal data to assist clinical decision-making. It has previously been shown to be useful in predicting progression in mild cognitive impairment and differentiating Alzheimer's disease (AD) and frontotemporal dementia. In this study, we use the DSI method to predict shunt surgery response for patients with iNPH. In this retrospective cohort study, a total of 284 patients (230 shunt responders and 54 non-responders) from the Kuopio NPH registry were analyzed with the DSI. Analysis included data from patients' memory disorder assessments, age, clinical symptoms, comorbidities, medications, frontal cortical biopsy, CT/MRI imaging (visual scoring of disproportion between Sylvian and suprasylvian subarachnoid spaces, atrophy of medial temporal lobe, superior medial subarachnoid spaces), APOE genotyping, CSF AD biomarkers, and intracranial pressure. Our analysis showed that shunt responders cannot be differentiated from non-responders reliably even with the large dataset available (AUC = 0.58). Prediction of the treatment response in iNPH is challenging even with our extensive dataset and refined analysis. Further research of biomarkers and indicators predicting shunt responsiveness is still needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Idiopathic normal pressure hydrocephalus
- Shunt response
- Computer-assisted diagnosis
- Prognosis
- Cognitive decline
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Luikku, Antti J.
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Hall, Anette
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Nerg, Ossi
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Koivisto, Anne M ...
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Hiltunen, Mikko
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Helisalmi, Seppo
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show more...
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Herukka, Sanna-K ...
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Sutela, Anna
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Kojoukhova, Mari ...
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Mattila, Jussi
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Lotjonen, Jyrki
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Rummukainen, Jaa ...
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Alafuzoff, Irina
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Jaaskelainen, Ju ...
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Remes, Anne M.
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Soininen, Hilkka
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Leinonen, Ville
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Acta Neurochirur ...
- By the university
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Uppsala University