| 1. |
- Ahlman, Håkan, 1947, et al.
(författare)
-
Clinical management of gastric carcinoid tumors.
- 1994
-
Ingår i: Digestion. - 0012-2823. ; 55 Suppl 3, s. 77-85
-
Tidskriftsartikel (refereegranskat)abstract
- Four types of gastric carcinoids have been identified: (1) multiple small body-fundus carcinoids associated with chronic atrophic gastritis type A (A-CAG); (2) sporadic solitary lesions without specific pathogenetic background (non-A-CAG); (3) carcinoidosis associated with Zollinger-Ellison/MEN 1 syndrome, and (4) rare tumors, e.g. gastrin cell tumors, neuroendocrine carcinomas and mixed endocrine-exocrine tumors. In a retrospective study of 15 patients with gastric carcinoids (11 A-CAG, 3 non-A-CAG and 1 gastrin cell tumor) over a 10-year period, the histopathological and clinical features were assessed. The A-CAG-type carcinoids were clinically silent with lymph node metastases in 2/11 cases but no hepatic metastases. The non-A-CAG-type carcinoids were malignant with disseminated disease, hormonal symptoms and increased urinary excretion of the main histamine metabolite, MeImAA. Five patients with A-CAG tumors were subjected to antrectomy to remove hypergastrinemia, which is thought to be of pathogenetic importance for these tumors. During the observation period (1.5-8 years) 1 patient developed recurrent tumors, while the other 4 showed persistent argyrophil cell hyperplasia. A prospective treatment protocol of these tumors is suggested with endoscopic removal of less numerous, small lesions as first-step therapy, followed by antrectomy at recurrence. Larger lesions should be excised in combination with antrectomy. Gastrectomy is reserved for the rare cases of invasive tumors with lymph node metastases. As evident from the outcome of patients with non-A-CAG tumors radical surgery should be performed whenever practicable.
|
|
| 2. |
- Warkentin, Siegbert, et al.
(författare)
-
Regional cerebral blood flow in schizophrenia: repeated studies during a psychotic episode
- 1990
-
Ingår i: Psychiatry Research. - 1872-7123 .- 0165-1781. ; 35:1, s. 27-38
-
Tidskriftsartikel (refereegranskat)abstract
- Regional cerebral blood flow (rCBF) measurements and clinical ratings were performed on 17 schizophrenic patients and a subgroup of 10 medication-free patients before and after treatment. While clinically exacerbated patients had normal blood flow, patients in remission showed a redistribution of flow with lower values in frontal areas. Anteroposterior ratios correlated with the degree of behavioral disturbances, suggesting that the level of frontal lobe activity in schizophrenia may be a function of the patient's clinical state at the time of study.
|
|
| 3. |
- Edling, C., et al.
(författare)
-
Long-term follow up of workers exposed to solvents
- 1990
-
Ingår i: British journal of industrial medicine. - 0007-1072. ; 47:2, s. 75-82
-
Tidskriftsartikel (refereegranskat)abstract
- Long term occupational exposure to organic solvents may cause adverse effects to the central nervous system. This collaborative study between six Swedish departments of occupational medicine examines the overall prognosis in terms of working capacity, symptoms, and psychometric test performance for individuals occupationally exposed to organic solvents. After re-analyses of the data from an initial clinical investigation of 111 men, the subjects were divided into two subgroups: one group of 65 with symptoms but no impairment on the tests and one group of 46 with toxic encephalopathy (symptoms and test impairment). At least five years after the initial examination the subjects were asked to attend a re-examination that included a structured medical interview and a psychometric investigation. The results indicate that effects on the central nervous system persist even when exposure has ceased. In the group of 46 more men had stopped working and were receiving sickness or early retirement pensions. This group also had reduced activity levels with regard to everyday life, leisure activities, and education or training and more neuropsychiatric symptoms. There was no support for the view that a solvent induced toxic encephalopathy is a progressive disease comparable with presenile dementia such as Alzheimer's disease or Pick's disease. If a worker was removed from exposure when he presented symptoms without signs of impairment in intellectual function recovery was seen in most cases.
|
|
| 4. |
- Minthon, Lennart, et al.
(författare)
-
Oral tetrahydroaminoacridine treatment of Alzheimer's disease evaluated clinically and by regional cerebral blood flow and EEG
- 1993
-
Ingår i: Dementia (Switzerland). - 1013-7424. ; 4:1, s. 32-42
-
Tidskriftsartikel (refereegranskat)abstract
- Neurochemical evidence indicates that cognitive impairment in dementia of Alzheimer type (DAT) is related to degeneration of cholinergic neurons in the brain. A pharmacological approach is treatment with a cholinesterase inhibitor such as tetrahydroaminoacridine (THA). THA treatment of 17 patients with DAT was studied with a double-blind crossover design with three types of treatment, THA + lecithin, THA + placebo and placebo + placebo. Each treatment period was 6 weeks with wash out periods of 2 weeks. The treatment was evaluated with clinical ratings, psychometric testing, EEG and regional cerebral blood flow (rCBF) measurements. No significant clinical differences between treatment periods were found in the total sample, but marked individual differences were observed. The patients were subdivided into three outcome groups based on four clinical measures: 6 patients improved (responders), 5 patients were mainly unchanged, and 6 patients showed further deterioration during the trial period of 26 weeks. Pretreatment rCBF in responders differed significantly from that of the deteriorated patients. EEG showed more high frequency activity among responders. Hepatotoxic side effects were observed in several cases. Three subjects showed marked increases of liver enzymes, with normalization following dose reduction. The majority of patients who improved or remained unchanged during the study chose to continue THA treatment in an open trial.
|
|
| 5. |
- Nilsson, Peter, et al.
(författare)
-
A bit-serial CMOS digital IF-filter for mobile radio using an on-chip clock
- 1994
-
Ingår i: Mobile communications advanced systems and components / Lecture notes in Computer Science. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1611-3349 .- 0302-9743. - 3540578560 ; 783, s. 510-521
-
Konferensbidrag (refereegranskat)abstract
- A chip for digital intermediate frequency filtering is introduced. The filter is intended move most of the analog intermediate frequency filtering to the digital domain in systems like the American mobile radio system (IS-54). It is a wave digital lattice filter realized with bit-serial arithmetic. Furthermore, a technique for local clocks on chip is presented. The method is based on a ring oscillator and a cycle counter which is controlled from outside the chip. A 0.8 micron technology custom test chip has been fabricated and tested.
|
|
| 6. |
- Warkentin, Siegbert, et al.
(författare)
-
Cycloid psychosis: regional cerebral blood flow correlates of a psychotic episode
- 1992
-
Ingår i: Acta Psychiatrica Scandinavica. - 0001-690X .- 1600-0447. ; 85:1, s. 23-29
-
Tidskriftsartikel (refereegranskat)abstract
- Eight patients meeting Leonhard's criteria for cycloid psychosis were investigated on repeated occasions during a psychotic episode, with regional cerebral blood flow measurements and clinical ratings. The results showed that, at admission to the hospital, when the patients were clinically exacerbated, the mean hemispheric blood flow was significantly elevated compared with values from a normal control group. The hemispheric blood flow level covaried significantly with the degree of clinical symptoms, such that the more elevated the cortical blood flow was, the more behaviorally disturbed was the patient. At discharge from the hospital, the patients had no residual symptoms and the cortical blood flow was normal. These findings differ distinctly from those commonly made in other psychoses, such as schizophrenia.
|
|
