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- Wiberg, Nana, et al.
(författare)
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Infant outcome at four years of age after intrapartum sampling of scalp blood lactate for fetal assessment. A cohort study
- 2018
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:3
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Tidskriftsartikel (refereegranskat)abstract
- Objective To correlate the value of lactate in fetal scalp blood at delivery and the outcomes of the offspring at four years of age. Methods Cases where scalp blood lactate was taken within sixty minutes before delivery were identified from the randomized trial "Determination of pH or lactate in fetal scalp blood in management of intrapartum fetal distress”. Data were grouped according to the generally accepted cutoffs for normality, pre-acidemia, acidemia and concentrations above mean +2 SD during the second stage. The outcome measures included gross-/fine motor function, vision, hearing, speaking and cognitive disorders, signs of central motor damage and referral to specialized pediatric services. Results 307 cases were available for final analyse. With normal scalp lactate concentration, the number of children with a diagnosed disorder was lower compared to the pre-acidemic/ acidemic groups, although the findings were only significant for fine motor dysfunction (p = 0.036). Elevated lactate values were significantly associated with increased risk for a poorer capacity of attention and understanding of instructions (OR 1.37, 95% CI 1.07–1.74), and for fine motor dysfunction (OR 1.22, 95% CI 1.00–1.49) at the age of four. Conclusion Higher levels of lactate in fetal scalp blood seems to be associated with increased risk of an aberrant developmental outcome at four years of age in some areas.
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| 2. |
- Andersson Granberg, Tobias, 1973-, et al.
(författare)
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Using Semi-professionals in Emergency Response
- 2016
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Ingår i: Proceedings of the 13th International Conference on Information Systems for Crisis Response and Management. - 9788460879848 ; , s. 1-6
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The term semi-professional can be used to denote occupational groups that do not have emergency response as their primary profession but who get additional responsibilities within rescue and response, e.g. by performing a first response or assisting the professional emergency services. In this study, four different groups of possible semi-professional resources are analyzed and compared. Similarities and differences between the four groups are discussed. Factors, important for the successful implementation of a cross-sector collaboration of this kind, are highlighted. The preliminary results show that all four groups have the potential to act as semi-professional resources within emergency response. Interestingly, the basic requirements are the same for all groups, despite different prerequisites.
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| 3. |
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| 4. |
- Berghauser Pont, Meta, 1972, et al.
(författare)
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PST
- 2019
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Annan publikation (mjukvara/multimedium) (övrigt vetenskapligt/konstnärligt)abstract
- PST is a tool for performing space syntax and regular accessibility analyses. It currently consists of two main parts - a C++ and Python library called Pstalgo and a plugin for the desktop application QGIS.PST is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version. The GNU General Public License is intended to guarantee your freedom to share and change all versions of a program--to make sure it remains free software for all its users.For latest download visit either the Chalmers publication page, or find "Releases" on the Github page.
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| 5. |
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| 6. |
- Blennow Nordström, Erik, et al.
(författare)
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Validity of the IQCODE-CA : An informant questionnaire on cognitive decline modified for a cardiac arrest population
- 2017
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Ingår i: Resuscitation. - : Elsevier. - 0300-9572 .- 1873-1570. ; 118, s. 8-14
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To examine the psychometric properties of a modified version of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), for a cardiac arrest population (IQCODE-CA). Methods: The IQCODE-CA, a 26-item observer-reported questionnaire, was completed by informants, defined as relatives or close friends, of 268 out-of-hospital cardiac arrest (OHCA) survivors who participated in the Target Temperature Management trial in a scheduled follow-up 180 +/- 14 days after OHCA. Survivors completed the Mini Mental State Examination (MMSE), the Rivermead Behavioural Memory Test (RBMT) and the Hospital Anxiety and Depression Scale (HADS). An exploratory factor analysis was performed. Associations between IQCODE-CA results and demographic variables along with other instruments were calculated. Area under the curve (AUC) ratios were evaluated to examine discrimination. Results: The IQCODE-CA measured one factor, global cognitive decline, with high internal consistency (ordinal alpha = 0.95). Age, gender or education did not influence the IQCODE-CA score. Associations with performance-based measures of global cognitive function as well as anxiety and depression ranged from small to moderate (rs = -0.29 to 0.38). AUC ratios ranged from fair to good (0.72-0.81). According to the MMSE and RBMT, the optimal cut-off score to identify cognitive decline on the IQCODE-CA was 3.04. Using this value, 53% of the survivors were under the cut-off. Conclusions: The IQCODE-CA identified a large amount of survivors with possible cognitive problems, making it useful when screening for cognitive decline post-CA. Due to lower AUC ratios than desired, additional performance-based measures should be used to improve the overall screening methodology. (C) 2017 Elsevier B.V. All rights reserved.
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| 7. |
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| 8. |
- Freischmidt, Axel, et al.
(författare)
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Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
- 2015
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Ingår i: Nature Neuroscience. - : Springer Science and Business Media LLC. - 1097-6256 .- 1546-1726. ; 18:5, s. 631-
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Tidskriftsartikel (refereegranskat)abstract
- Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative syndrome hallmarked by adult-onset loss of motor neurons. We performed exome sequencing of 252 familial ALS (fALS) and 827 control individuals. Gene-based rare variant analysis identified an exome-wide significant enrichment of eight loss-of-function (LoF) mutations in TBK1 (encoding TANK-binding kinase 1) in 13 fALS pedigrees. No enrichment of LoF mutations was observed in a targeted mutation screen of 1,010 sporadic ALS and 650 additional control individuals. Linkage analysis in four families gave an aggregate LOD score of 4.6. In vitro experiments confirmed the loss of expression of TBK1 LoF mutant alleles, or loss of interaction of the C-terminal TBK1 coiled-coil domain (CCD2) mutants with the TBK1 adaptor protein optineurin, which has been shown to be involved in ALS pathogenesis. We conclude that haploinsufficiency of TBK1 causes ALS and fronto-temporal dementia.
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| 9. |
- Gasch, Tobias
(författare)
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Concrete as a multi-physical material with applications to hydro power facilities
- 2016
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- During its lifetime, a concrete structure is subjected to many different actions, ranging from mechanical loads to environmental actions. To accurately predict its integrity from casting and throughout its service life, a modelling strategy is required that considers mechanical loading but also implicitly accounts for physical effects such as temperature and moisture variations. This is especially true for large concrete structures found in many infrastructure applications such as bridges, nuclear power plants and dams. Modelling concrete as a multi-physical material is becoming an increasingly used approach for which large research efforts are being made, including the development of more refined mathematical and numerical methods as well as considering more physical and chemical variables in the coupled model.The research project, of which this licentiate thesis is the first phase, aims at investigating aging concrete structures at hydro power facilities, with focus on the internal structures of the power plants. This thesis presents a review of advanced mathematical methods and concepts for modelling aging concrete found in the literature which can later be applied to study such structures. The focus is on models that describe the deformational behaviour of concrete where aspects such as aging, cracking, creep and shrinkage are investigated. However, in order to accurately describe such phenomena, a multi-physical approach is adopted where moisture and temperature variations in the concrete are studied. Also, models that describe the chemical behaviour related to hydration and thus in extension aging, are also reviewed and introduced in the multi-physical framework. The use of such models are discussed in the context of the finite element method (FEM), in which coupled models are implemented, verified and applied in the appended papers using two different FE codes.Several verification examples are presented covering different aspects of the implemented models, both in isolation and coupled in a multi-physical setting. By comparing the numerical results with experimental data from the literature it can be shown that it is possible to predict most aspects of aging concrete that have been of interest here. While these examples are all on a laboratory scale, numerical examples and case studies are also provided that exemplify how the models can be applied on a structural scale. By using the developed analysis tools, valuable information and insights can be gained on aging concrete structures and these tools will in the next phase of the research project be applied to large concrete structures at hydro power facilities.
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| 10. |
- Gasch, Tobias
(författare)
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Multiphysical analysis methods to predict the ageing and durability of concrete
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- With the societal demand for sustainability and the increasing age of infrastructure, a crucial task for the civil engineering community is to improve the durability of concrete structures. This thesis aims to contribute to such development through theoretical studies using mathematical modelling and numerical simulations. During its service life, a concrete structure is subjected to many different actions, ranging from mechanical loads to chemical and physical processes. Hence, a sound modelling strategy requires multiphysics and the inclusion of coupled chemical and physical fields (e.g. temperature, moisture and cement hydration) in addition to methods that describe mechanical integrity of the material. Conditions and phenomena critical for concrete structures at hydropower facilities have been of particular interest to study.The thesis presents several mathematical models of various complexity to describe the multiphysical behaviour of concrete using a material point description. A significant focus is on models that describe the mechanical behaviour of concrete where aspects such as ageing, cracking, creep and shrinkage are investigated. For the creep behaviour, a state-of-the-art model based on the Microprestress–Solidification (MPS) theory is reviewed and further developed. The appended papers (III to IV) presents a mathematical framework for the modelling of durability aspects of concrete based on multiphase porous media theory. The governing equations are derived with the Thermodynamically Constrained Averaging Theory (TCAT) as a starting point. It is demonstrated how this framework can be applied to a broad variety of phenomena related to durability; from the casting and hardening of concrete to the long-term absorption of water into air-entrained concrete. The Finite Element Methods (FEM) is used to solve the proposed mathematical models, and their capabilities are verified using experimental data from the literature.The main research contribution is the development and evaluation of theoretical models that advance the understanding and improve knowledge of the ageing and durability of concrete and concrete structures. More precisely, it is shown how multiphysical models and the developed multiphase framework can be used to gain insights on the material behaviour of concrete at smaller scales while they are also applicable to structural-scale simulations. During all model development, the efficient solution of structural problems has been fundamental. Through case studies and several examples from the literature, it is exemplified how these models can be used to enhance the performance and thereby increase the durability of concrete structures.
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