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Genome-wide meta-an...
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium
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- Merino, Jordi (author)
- Massachusetts General Hospital,Broad Institute
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- Dashti, Hassan S. (author)
- Massachusetts General Hospital,Broad Institute
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- Li, Sherly X. (author)
- University of Cambridge
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- Sarnowski, Chloé (author)
- Boston University
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- Justice, Anne E. (author)
- University of North Carolina,Sigfried and Janet Weis Center for Research
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- Graff, Misa (author)
- University of North Carolina
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Papoutsakis, Constantina (author)
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Smith, Caren E. (author)
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- Dedoussis, George V. (author)
- Harokopio University
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- Lemaitre, Rozenn N. (author)
- University of Washington
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- Wojczynski, Mary K. (author)
- Washington University in St. Louis
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- Männistö, Satu (author)
- Finnish National Institute for Health and Welfare
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- Ngwa, Julius S. (author)
- Johns Hopkins Bloomberg School of Public Health,Boston University
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- Kho, Minjung (author)
- University of Michigan
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- Ahluwalia, Tarunveer S. (author)
- University of Copenhagen
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- Pervjakova, Natalia (author)
- Imperial College London,University of Tartu,Finnish National Institute for Health and Welfare
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- Houston, Denise K. (author)
- Wake Forest University
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- Bouchard, Claude (author)
- Pennington Biomedical Research Center
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- Huang, Tao (author)
- Peking University
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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Frazier-Wood, Alexis C. (author)
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- Mook-Kanamori, Dennis O. (author)
- Leiden University Medical Centre
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- Pérusse, Louis (author)
- Laval University,Institute of Nutrition and Functional Foods, Canada
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Pennell, Craig E. (author)
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- de Vries, Paul S. (author)
- University of Texas
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- Voortman, Trudy (author)
- Erasmus University Medical Center
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Li, Olivia (author)
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- Kanoni, Stavroula (author)
- Queen Mary University
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- Rose, Lynda M. (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Lehtimäki, Terho (author)
- University of Tampere
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- Zhao, Jing Hua (author)
- University of Cambridge
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- Feitosa, Mary F. (author)
- Washington University in St. Louis
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- Luan, Jian’an (author)
- University of Cambridge
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McKeown, Nicola M. (author)
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- Smith, Jennifer A. (author)
- University of Michigan
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- Hansen, Torben (author)
- University of Copenhagen
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- Eklund, Niina (author)
- Finnish National Institute for Health and Welfare
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- Nalls, Mike A. (author)
- Data Tecnica International,National Institute on Aging, United States
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- Rankinen, Tuomo (author)
- Pennington Biomedical Research Center
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Huang, Jinyan (author)
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- Hernandez, Dena G. (author)
- National Institute on Aging, United States
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- Schulz, Christina Alexandra (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Manichaikul, Ani (author)
- University of Virginia
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- Li-Gao, Ruifang (author)
- Leiden University Medical Centre
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- Vohl, Marie Claude (author)
- Institute of Nutrition and Functional Foods, Canada,Laval University
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Wang, Carol A. (author)
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- van Rooij, Frank J.A. (author)
- Erasmus University Medical Center
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- Shin, Jean (author)
- Hospital for Sick Children, Toronto
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Perola, Markus (author)
- Finnish National Institute for Health and Welfare
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(creator_code:org_t)
- 2018-07-09
- 2019
- English 13 s.
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In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 24:12, s. 1920-1932
- Related links:
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http://dx.doi.org/10...
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https://zenodo.org/r...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the genetic landscape of macronutrient intake, identifying 12 suggestively significant loci (P < 1 × 10−6) associated with intake of any macronutrient in 91,114 European ancestry participants. Four loci replicated and reached genome-wide significance in a combined meta-analysis including 123,659 European descent participants, unraveling two novel loci; a common variant in RARB locus for carbohydrate intake and a rare variant in DRAM1 locus for protein intake, and corroborating earlier FGF21 and FTO findings. In additional analysis of 144,770 participants from the UK Biobank, all identified associations from the two-stage analysis were confirmed except for DRAM1. Identified loci might have implications in brain and adipose tissue biology and have clinical impact in obesity-related phenotypes. Our findings provide new insight into biological functions related to macronutrient intake.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Merino, Jordi
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Dashti, Hassan S ...
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Li, Sherly X.
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Sarnowski, Chloé
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Justice, Anne E.
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Graff, Misa
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show more...
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Papoutsakis, Con ...
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Smith, Caren E.
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Dedoussis, Georg ...
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Lemaitre, Rozenn ...
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Wojczynski, Mary ...
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Männistö, Satu
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Ngwa, Julius S.
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Kho, Minjung
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Ahluwalia, Tarun ...
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Pervjakova, Nata ...
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Houston, Denise ...
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Bouchard, Claude
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Huang, Tao
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Orho-Melander, M ...
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Frazier-Wood, Al ...
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Mook-Kanamori, D ...
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Pérusse, Louis
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Pennell, Craig E ...
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de Vries, Paul S ...
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Voortman, Trudy
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Li, Olivia
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Kanoni, Stavroul ...
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Rose, Lynda M.
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Lehtimäki, Terho
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Zhao, Jing Hua
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Feitosa, Mary F.
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Luan, Jian’an
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McKeown, Nicola ...
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Smith, Jennifer ...
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Hansen, Torben
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Eklund, Niina
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Nalls, Mike A.
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Rankinen, Tuomo
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Huang, Jinyan
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Hernandez, Dena ...
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Schulz, Christin ...
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Manichaikul, Ani
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Li-Gao, Ruifang
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Vohl, Marie Clau ...
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Wang, Carol A.
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van Rooij, Frank ...
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Shin, Jean
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Ericson, Ulrika
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Perola, Markus
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Molecular Psychi ...
- By the university
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Lund University