↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Petronio A. S.) srt2:(2016)"

Search: WFRF:(Petronio A. S.) > (2016)

Result 1-2 of 2

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Portier, CJ, et al. (author) Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA) 2016 In: Journal of epidemiology and community health. - : BMJ. - 1470-2738 .- 0143-005X. ; 70:8, s. 741-745 Journal article (peer-reviewed)
2.	Porpino, Suenia K. P., et al. (author) Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II-mediated hypertension 2016 In: British Journal of Pharmacology. - : Wiley. - 0007-1188 .- 1476-5381. ; 173:14, s. 2290-2302 Journal article (peer-reviewed)abstract Background and PurposeNO deficiency and oxidative stress are crucially involved in the development or progression of cardiovascular disease, including hypertension and stroke. We have previously demonstrated that acute treatment with the newly discovered organic nitrate, 2-nitrate-1,3-dibuthoxypropan (NDBP), is associated with NO-like effects in the vasculature. This study aimed to further characterize the mechanism(s) and to elucidate the therapeutic potential in a model of hypertension and oxidative stress. Experimental ApproachA combination of ex vivo, in vitro and in vivo approaches was used to assess the effects of NDBP on vascular reactivity, NO release, NADPH oxidase activity and in a model of hypertension. Key ResultsEx vivo vascular studies demonstrated NDBP-mediated vasorelaxation in mesenteric resistance arteries, which was devoid of tolerance. In vitro studies using liver and kidney homogenates revealed dose-dependent and sustained NO generation by NDBP, which was attenuated by the xanthine oxidase inhibitor febuxostat. In addition, NDBP reduced NADPH oxidase activity in the liver and prevented angiotensin II-induced activation of NADPH oxidase in the kidney. In vivo studies showed that NDBP halted the progression of hypertension in mice with chronic angiotensin II infusion. This was associated with attenuated cardiac hypertrophy, and reduced NADPH oxidase-derived oxidative stress and fibrosis in the kidney and heart. Conclusion and ImplicationsThe novel organic nitrate NDBP halts the progression of angiotensin II-mediated hypertension. Mechanistically, our findings suggest that NDBP treatment is associated with sustained NO release and attenuated activity of NADPH oxidase, which to some extent requires functional xanthine oxidase.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-2 of 2

Refine your search

Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Forastiere, F (1); Rodriguez, T. (1); Roy, D. (1); Weiderpass, E (1); Kromhout, H (1); Hansen, J (1); show more...; Bruzzi, P (1); Larsson, Erik (1); Belyaev, I (1); Goldberg, M (1); Miller, AB (1); Vineis, P (1); Belpoggi, F (1); Naidoo, S (1); Burns, K (1); Carlstrom, Mattias (1); Magnani, C (1); Terracini, B (1); Armstrong, BK (1); Kortenkamp, A. (1); Roosli, M (1); Biggeri, A (1); Michelozzi, P (1); DeWitt, J. (1); Huang, W (1); Weitzberg, Eddie (1); Huff, J (1); Mirabelli, D (1); Sass, J (1); Hardell, L (1); Davis, D (1); Landrigan, PJ (1); Hauptmann, M (1); Sutton, P. (1); Perry, MJ (1); Portier, CJ (1); Cocco, P (1); Lynch, CF (1); Consonni, D (1); Demers, PA (1); Merler, E (1); Clapp, R. (1); Thomas, DB (1); Miligi, L (1); Smith, MT (1); Zeeb, H (1); Mandrioli, D (1); Zambon, P (1); Zollbrecht, Christa (1); Peleli, Maria (1); show less...

University: Karolinska Institutet (2); Uppsala University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2016 (2)Undo refine

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view