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- Bollerslev, J., et al.
(författare)
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Medical observation, compared with parathyroidectomy, for asymptomatic primary hyperparathyroidism: a prospective, randomized trial
- 2007
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 92:5, s. 1687-92
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: The clinical presentation of primary hyperparathyroidism (pHPT) has changed during the last half century, and the diagnosis is now more often made by chance in patients with no specific symptoms. OBJECTIVE: The present study is a randomized, controlled trial that investigates the effects of parathyroidectomy or medical observation in mild asymptomatic pHPT on morbidity and quality of life (QoL). DESIGN/SETTING/PATIENTS: A total of 191 patients (26 men) with asymptomatic pHPT [mean age 64.2 +/- 7.4 (sd) yr] were recruited in the study and randomized to medical observation (serum calcium level 2.69 +/- 0.08 mmol/liter) or surgery (2.70 +/- 0.08 mmol/liter). We here report baseline and 1 (n = 119) and 2 yr data (n = 99) on those who had completed the follow-up visits by the end of the inclusion period. RESULTS: At baseline, the patients had significantly lower QoL (SF-36) and more psychological symptoms, compared with age- and sex-matched healthy subjects. The two groups were similar at baseline, and no clinically significant changes in these parameters were seen during the observation time. Calcium and PTH normalized after surgery. The areal bone mineral density increased in the group randomized to operation, whereas the bone mineral density remained stable in the medical observation group. No change in kidney function (creatinine) or blood pressure was observed longitudinally or between the groups. CONCLUSIONS: Asymptomatic patients with mild pHPT have decreased QoL and more psychological symptoms than normal controls. No benefit of operative treatment, compared with medical observation, was found on these measures so far.
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| 3. |
- Lindqvist, Ann-Sophie, 1973, et al.
(författare)
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AAS abuse in former competitive sport athletes.
- 2007
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Ingår i: First Nordic Conference on Abuse of Anabolic Androgenic Steroids and Anti-Doping Work, Uppsala, 2007.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Anderberg, Cecilia, et al.
(författare)
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Alternative descriptions of roughness for cylinder liner production
- 2009
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Ingår i: Journal of Materials Processing Technology. - Amsterdam : Elsevier. - 0924-0136 .- 1873-4774. ; 209:4, s. 1936-1942
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Tidskriftsartikel (refereegranskat)abstract
- The roughness of stratified surfaces such as cylinder liners, produced by plateau honing, is functionally important in their tribology but is notoriously difficult to characterise. An issue in manufacturing quality control related to their tribological function is the comparative ability of various roughness characterisation systems. In this paper the Rk family of parameters is compared with the Rq family as regards stability and discrimination. When coefficients of variation of the two parameter families are compared as a measure of stability, CVs of individual parameters vary between 8% and 20% but do not seem to indicate a clear advantage to either family. When the correlation of parameters within and between the two groups is computed as a measure of relative discriminative ability, many parameters are found to be highly correlated, to the point where values of Rpk and Rpq are effectively indistinguishable. The relative robustness of the parameters is also established by simulation of surface or measurement artefacts: outlying peaks and valleys, high-frequency noise, changes in stylus or skid radius, changes in high-pass filter and in assessment length. Outlying peaks cause a large increase in Rpk, while outlying valleys have little effect. The Rq parameters are more sensitive to high-frequency noise than the Rk parameters. Increasing the stylus radius reduced the valley parameters, while adding a 25 mm radius skid increased Rk and Rpq by as much as 15%. Increasing the short-wavelength cut-off from 2.5 m to 8 m reduced most parameters, particularly the peak parameters, while replacing the robust Gaussian filter used throughout by a valley-suppression filter had little effect. Finally reducing the assessment length from 17 mm to 4 mm decreased the values of many parameters by up to 11%. Increasing plateau honing time decreased plateau roughness, while increasing pressure during coarse honing increased valley roughness, but these changes could not be correlated with roughness parameters. This suggests that the optimum parameter set has not yet been found. 2008 Elsevier B.V. All rights reserved.
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| 10. |
- Dahlgren, Eva, et al.
(författare)
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Sertoli-Leydig cell tumour in a postmenopausal woman showing all facets of the insulin resistance syndrome (IRS)
- 2005
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Ingår i: Ups J Med Sci. - 0300-9734. ; 110:3, s. 233-6
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Tidskriftsartikel (refereegranskat)abstract
- Sertoli-Leydig cell tumours are rare sex stromal tumours with an incidence of < 0.5% of all ovarian tumours. Most frequently this tumour occurs in young women with a history of amenorrhoea, hirsutism and lowered pitch. Here, we report on a woman with IRS, postmenopausal virilization and increased testosterone levels due to a Sertoli-Leydig cell tumour. This is the first case to suggest an association between IRS and Sertoli-Leydig cell tumours. Furthermore, we highlight the difficulties in detecting this ovarian tumour with sonography.
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