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| 2. |
- Clark, Andrew G., et al.
(författare)
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Evolution of genes and genomes on the Drosophila phylogeny
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
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Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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| 3. |
- Berman, F., et al.
(författare)
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New grid scheduling and rescheduling methods in the GrADS Project
- 2005
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Ingår i: International journal of parallel programming. - : Springer Science and Business Media LLC. - 0885-7458 .- 1573-7640. ; 33:3-Feb, s. 209-229
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Tidskriftsartikel (refereegranskat)abstract
- The goal of the Grid Application Development Software (GrADS) Project is to provide programming tools and an execution environment to ease program development for the Grid. This paper presents recent extensions to the GrADS software framework: a new approach to scheduling workflow computations, applied to a 3-D image reconstruction application; a simple stop/migrate/restart approach to rescheduling Grid applications, applied to a QR factorization benchmark; and a process-swapping approach to rescheduling, applied to an N-body simulation. Experiments validating these methods were carried out on both the GrADS MacroGrid (a small but functional Grid) and the MicroGrid (a controlled emulation of the Grid).
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| 4. |
- Jiang, Shi, et al.
(författare)
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Fe-S complexes containing five-membered heterocycles : novel models for the active site of hydrogenases with unusual low reduction potential
- 2007
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Ingår i: Dalton Transactions. - : Royal Society of Chemistry (RSC). - 1477-9226 .- 1477-9234. ; :8, s. 896-902
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Tidskriftsartikel (refereegranskat)abstract
- Three biomimetic 2Fe2S complexes [{(mu-SCH2)(2)NCH2(2-C4H3O)}](Fe-2(CO)(6)) (6a), [{(mu-SCH2)(2) NCH2(2-C4H3S)}](Fe-2(CO)(6)) (6b) and [{(mu-SCH2)(2)NCH2(5-Br-2-C4H2S)}Fe-2(CO)(6)] (6c) were prepared as models for the active site of Fe-only hydrogenase by the convergent process from [(mu-S-2)Fe-2(CO)(6)] and N,N-bis(hydromethyl)-2-furan and thiophene. The structures of these complexes were identified spectroscopically and crystallographically. The electrochemical behavior of the complexes 6a and 6c was unique as they showed catalytic proton reduction with a low reduction potential at -1.13 and -1.09 V vs Fc/Fc(+), respectively, in the presence of HClO4.
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| 5. |
- Jiang, Shi, et al.
(författare)
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Preparation, characteristics and crystal structures of novel N-heterocyclic carbene substituted furan- and pyridine-containing azadithiolate Fe-S complexes
- 2007
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Ingår i: Polyhedron. - : Elsevier BV. - 0277-5387 .- 1873-3719. ; 26:7, s. 1499-1504
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Tidskriftsartikel (refereegranskat)abstract
- Two novel N-heterocyclic carbene disubstituted furan- and pyridine-containing azadithiolate Fe-only hydrogenase models (2 and 4) have been synthesized, and characterized by IR and H-1 NMR spectra and X-ray single crystal diffraction. Cyclic voltammetry (CV) experiments indicate that they show more negative reductive potentials at -2.53 V and -2.49 V, respectively versus the ferrocene/ferrocenium couple (Fc/Fc(+)) and are easier to capture proton attributing to the strong electron-donating ligand NHC. After the protonation under F3CCO2H the reductive potentials of 2 and 4 have 1.02 V and 0.77 V shifts, indicating the formation of Fe-H-Fe bond. The results also are confirmed by the data changes in IR spectra and the negative H signals are detected by 1H NMR spectra at -27 ppm and -55 ppm.
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| 7. |
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| 8. |
- Lindblad-Toh, Kerstin, et al.
(författare)
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Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- 2005
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
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Tidskriftsartikel (refereegranskat)abstract
- Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
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| 9. |
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| 10. |
- Shi, W, et al.
(författare)
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Synthesis and characterization of a six-coordinate monomeric Mn(III) complex with SOD-like activity
- 2006
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Ingår i: Journal of Coordination Chemistry. - : Informa UK Limited. - 1026-7441 .- 0095-8972 .- 1029-0389. ; 59:2, s. 119-130
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Tidskriftsartikel (refereegranskat)abstract
- The complex [Mn-III(HL)(L)(py)(CH3OH)](CH3OH)-C-. (H2L=2-ortho-hydroxyphenylbenzimidazole, py pyridine), 1, has been characterized spectroscopically and by X-ray crystallography. The complex is triclinic, space group P-1(-) with a = 10.396(2), b = 10.7340(10), c = 15.193(2) angstrom, alpha = 73.193(4)degrees, beta = 76.283(8)degrees, gamma = 61.400(40)degrees, V = 1415.1(4)angstrom(3), Z = 2, D-c = 1.445 Mg m(-3), M-r = 615.56, mu = 0.515 mm(-1), F(000) = 640, R = 0.0631, wR = 0.1525. Manganese is six-coordinate in an N3O3 ligand sphere created by two bidentate H2L ligands and solvent molecules with a slightly distorted, axially elongated octahedral geometry. Electronic absorption spectra show pi-pi* and Ligand Metal Charge Transfer (LMCT) transitions in the UV region and d-d transitions in the visible region. Solvent molecules coordinated to the Mn(III) ion in the crystal are thought to retain their coordination in solution. It is shown that 1 has reaction activity with the superoxide ion, as indicated by inhibition of pyrogallol autoxidation and by spin trapping electron paramagnetic resonance (EPR) spectroscopy. The N3O3 ligand set in 1 is similar to that in native MnSOD (superoxide dismutatase) in the substrate-bound state. The correlation between the ligand set in 1 and its reaction with the superoxide ion is discussed.
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