1. |
|
|
2. |
- Leusink, M., et al.
(författare)
-
A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering
- 2016
-
Ingår i: Pharmacogenomics. - : Future Medicine Ltd. - 1462-2416 .- 1744-8042. ; 17:6, s. 583-591
-
Tidskriftsartikel (refereegranskat)abstract
- Aim: To find new genetic loci associated with statin response, and to investigate the association of a genetic risk score (GRS) with this outcome. Patients & methods: In a discovery meta-analysis (five studies, 1991 individuals), we investigated the effects of approximately 50000 single nucleotide polymorphisms on statin response, following up associations with p < 1 × 10-4 (three independent studies, 5314 individuals). We further assessed the effect of a GRS based on SNPs in ABCG2, LPA and APOE. Results: No new SNPs were found associated with statin response. The GRS was associated with reduced statin response: 0.0394 mmol/l per allele (95% CI: 0.0171-0.0617, p = 5.37 × 10-4). Conclusion: The GRS was associated with statin response, but the small effect size (∼2% of the average low-density lipoprotein cholesterol reduction) limits applicability. © Future Medicine Ltd 2016.
|
|