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Mannan-binding lect...
Mannan-binding lectin modulates the response to HSV-2 infection.
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Gadjeva, M (författare)
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Paludan, S R (författare)
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Thiel, S (författare)
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visa fler...
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Slavov, V (författare)
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Ruseva, M (författare)
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- Eriksson, Kristina, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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- Löwhagen, Gun-Britt, 1942 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology
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Shi, L (författare)
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Takahashi, K (författare)
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Ezekowitz, A (författare)
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Jensenius, J C (författare)
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(creator_code:org_t)
- 2004-09-27
- 2004
- Engelska.
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Ingår i: Clinical and experimental immunology. - : Oxford University Press (OUP). - 0009-9104 .- 1365-2249. ; 138:2, s. 304-11
- Relaterad länk:
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https://onlinelibrar...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Viruses have developed numerous strategies to escape recognition by the immune system. However, some viruses such as herpes simplex virus-2 (HSV-2) are recognized by initiators of the complement system, e.g. mannan-binding lectin (MBL). To study the effects of MBL deficiency during viral infection we have chosen a model of generalized HSV-2 infection. We infected MBL-A and MBL-C double knock-out mice (DKO) with HSV-2 via the intraperitoneal (i.p.) route. DKO mice cleared HSV-2 from the liver less efficiently than the comparable wild-type animals. The impairment to effectively neutralize HSV-2 correlated with compromised liver function as measured by increased plasma levels of alanine-amino transferase. No differences in the viral burden were found in other organs such as spleen or brain. Thus, MBL-mediated protection was limited to the effects of preservation of liver homeostasis. Reconstitution with recombinant human MBL before and during the HSV-2 infection dramatically lowered the viral titres in the liver. Taken together, the data show that MBL modulates the response to HSV-2 in mice by affecting neutralization of the virus. To analyse if MBL plays a role in establishment and progression of human HSV-2 infection we analysed MBL levels in the serum samples from asymptomatic (virus-exposed people who have never displayed symptoms of HSV-2 infection) and symptomatic HSV-2 patients (people with recurrent HSV-2 infections). We found that the frequency of the MBL deficiency (<100 ng/ml) was higher in the symptomatic group and significantly different from that in the asymptomatic group (P = 0.0369). This suggests that lack of MBL-mediated complement activation increases susceptibility to viral infection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Adult
- Aged
- Alanine Transaminase
- blood
- Animals
- Brain
- immunology
- Female
- Herpes Genitalis
- immunology
- Herpes Simplex
- blood
- immunology
- Herpesvirus 2
- Human
- immunology
- Homeostasis
- immunology
- Humans
- Liver
- immunology
- Male
- Mannose-Binding Lectin
- blood
- immunology
- Mice
- Mice
- Knockout
- Middle Aged
- Recombinant Proteins
- immunology
- Recurrence
- Spleen
- immunology
- Viral Load
- methods
- Viral Proteins
- immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gadjeva, M
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Paludan, S R
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Thiel, S
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Slavov, V
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Ruseva, M
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Eriksson, Kristi ...
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visa fler...
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Löwhagen, Gun-Br ...
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Shi, L
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Takahashi, K
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Ezekowitz, A
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Jensenius, J C
-
visa färre...
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Göteborgs universitet