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rs641738C>T near MB...
rs641738C>T near MBOAT7 is associated with liver fat, ALT, and fibrosis in NAFLD: a meta-analysis.
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Teo, Kevin (author)
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Abeysekera, Kushala W M (author)
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Adams, Leon (author)
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show more...
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Aigner, Elmar (author)
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Anstee, Quentin M (author)
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Banales, Jesus M (author)
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Banerjee, Rajarshi (author)
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Basu, Priyadarshi (author)
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Berg, Thomas (author)
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Bhatnagar, Pallav (author)
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Buch, Stephan (author)
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Canbay, Ali (author)
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Caprio, Sonia (author)
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Chatterjee, Ankita (author)
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Chen, Yii-Der Ida (author)
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Chowdhury, Abhijit (author)
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Daly, Anna K (author)
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Christian, Datz (author)
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de Gracia Hahn, Dana (author)
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DiStefano, Johanna K (author)
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Dong, Jiawen (author)
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Duret, Amedine (author)
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Emdin, Connor (author)
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Fairey, Madison (author)
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Gerhard, Glenn S (author)
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Guo, Xiuqing (author)
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Hampe, Jochen (author)
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Hickman, Matthew (author)
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Heintz, Lena (author)
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Hudert, Christian (author)
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Hunter, Harriet (author)
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Kelly, Matt (author)
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Kozlitina, Julia (author)
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Krawczyk, Marcin (author)
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Lammert, Frank (author)
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Langenberg, Claudia (author)
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Lavine, Joel (author)
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Li, Lin (author)
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Lim, Hong Kai (author)
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Loomba, Rohit (author)
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Luukkonen, Panu K (author)
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Melton, Philip E (author)
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Mori, Trevor A (author)
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Palmer, Nicholette D (author)
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Parisinos, Constantinos A (author)
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Pillai, Sreekumar G (author)
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Qayyum, Faiza (author)
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Reichert, Matthias C (author)
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- Romeo, Stefano, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Rotter, Jerome I (author)
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Im, Yu Ri (author)
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Santoro, Nicola (author)
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Schafmayer, Clemens (author)
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Speliotes, Elizabeth K (author)
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Stender, Stefan (author)
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Stickel, Felix (author)
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Still, Christopher D (author)
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Strnad, Pavel (author)
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Taylor, Kent D (author)
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Tybjaerg-Hansen, Anne (author)
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Umano, Giuseppina Rosaria (author)
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Utukuri, Mrudula (author)
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Valenti, Luca (author)
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Wagenknecht, Lynne E (author)
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Wareham, Nicholas J (author)
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Watanabe, Richard m (author)
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Wattacheril, Julia (author)
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Yaghootkar, Hanieh (author)
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Yki-Järvinen, Hannele x (author)
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Young, Kendra A (author)
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Mann, Jake P (author)
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Journal of hepatology. - : Elsevier BV. - 1600-0641 .- 0168-8278. ; 74:1, s. 20-30
- Related links:
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http://www.journal-o...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated with hepatic fat and advanced histology in non-alcoholic fatty liver disease (NAFLD), however, these findings have not been consistently replicated in the literature. We aimed to establish whether rs641738C>T is a risk factor across the spectrum of NAFLD and characterize its role in the regulation of related metabolic phenotypes through meta-analysis.We performed meta-analysis of studies with data on the association between rs641738C>T genotype and: liver fat, NAFLD histology, and serum ALT, lipids, or insulin. These included directly genotyped studies and population-level data from genome-wide association studies (GWAS). We performed random effects meta-analysis using recessive, additive, and dominant genetic models.Data from 1,066,175 participants (9,688 with liver biopsies) across 42 studies were included in the meta-analysis. rs641738C>T was associated with higher liver fat on CT/MRI (+0.03 standard deviations [95% CI: 0.02 - 0.05], pz=4.8x10-5) and diagnosis of NAFLD (OR 1.17 [95% CI 1.05 - 1.3], pz=0.003) in Caucasian adults. The variant was also positively associated with presence of advanced fibrosis (OR 1.22 [95% CI: 1.03 - 1.45], pz=0.021) in Caucasian adults using a recessive model of inheritance (CC+CT vs. TT). Meta-analysis of data from previous GWAS found the variant to be associated with higher ALT (pz=0.002) and lower serum triglycerides (pz=1.5x10-4). rs641738C>T was not associated with fasting insulin and no effect was observed in children with NAFLD.Our study validates rs641738C>T near MBOAT7 as a risk factor for the presence and severity of NAFLD in individuals of European descent.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Teo, Kevin
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Abeysekera, Kush ...
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Adams, Leon
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Aigner, Elmar
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Anstee, Quentin ...
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Banales, Jesus M
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show more...
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Banerjee, Rajars ...
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Basu, Priyadarsh ...
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Berg, Thomas
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Bhatnagar, Palla ...
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Buch, Stephan
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Canbay, Ali
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Caprio, Sonia
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Chatterjee, Anki ...
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Chen, Yii-Der Id ...
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Chowdhury, Abhij ...
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Daly, Anna K
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Christian, Datz
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de Gracia Hahn, ...
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DiStefano, Johan ...
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Dong, Jiawen
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Duret, Amedine
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Emdin, Connor
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Fairey, Madison
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Gerhard, Glenn S
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Guo, Xiuqing
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Hampe, Jochen
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Hickman, Matthew
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Heintz, Lena
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Hudert, Christia ...
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Hunter, Harriet
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Kelly, Matt
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Kozlitina, Julia
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Krawczyk, Marcin
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Lammert, Frank
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Langenberg, Clau ...
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Lavine, Joel
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Li, Lin
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Lim, Hong Kai
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Loomba, Rohit
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Luukkonen, Panu ...
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Melton, Philip E
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Mori, Trevor A
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Palmer, Nicholet ...
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Parisinos, Const ...
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Pillai, Sreekuma ...
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Qayyum, Faiza
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Reichert, Matthi ...
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Romeo, Stefano, ...
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Rotter, Jerome I
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Im, Yu Ri
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Santoro, Nicola
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Schafmayer, Clem ...
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Speliotes, Eliza ...
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Stender, Stefan
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Stickel, Felix
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Still, Christoph ...
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Strnad, Pavel
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Taylor, Kent D
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Tybjaerg-Hansen, ...
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Umano, Giuseppin ...
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Utukuri, Mrudula
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Valenti, Luca
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Wagenknecht, Lyn ...
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Wareham, Nichola ...
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Watanabe, Richar ...
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Wattacheril, Jul ...
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Yaghootkar, Hani ...
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Yki-Järvinen, Ha ...
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Young, Kendra A
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Mann, Jake P
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of hepat ...
- By the university
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University of Gothenburg