| 21. |
- Engstrom, PG, et al.
(författare)
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Complex Loci in human and mouse genomes
- 2006
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Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 2:4, s. 564-577
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Tidskriftsartikel (refereegranskat)
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| 22. |
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| 23. |
- Högström, Anette E.S., et al.
(författare)
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Late Ordovician sclerites in the Siljan District, Sweden.
- 2007
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Ingår i: WOGOGOB 2007, 9th meeting of the WOrking Group on Ordovician Geology Of Baltoscandia. - 9789171587886 ; , s. 110-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Isolated and semi-articulated sclerites of machaeridians are common in the Upper Ordovician (lower Nabala Stage) Fjäcka Shale of the Siljan District in Sweden. The organic rich shale offers a high preservation potential, preserving a dysaerobic, quiet deepwater environment. In the succeeding carbonate mounds of the Boda Limestone (Nabala-Porkuni stage) machaeridians and other sclerite bearing animals have hitherto been unknown. Though still rare, the presence of various sclerites in environments such as the carbonate mud mounds isnot surprising, as many of these taxa are widespread stratigraphically, geographically and environmentally.Amongst the machaeridian sclerites perhaps the most striking find are a few minute sclerites from pockets in the Kallholn and Solberga quarries. These animals are associated with minute fauna of gastropods, ostracodes and complete trilobites, which may have belonged to a cryptofauna. However, the presence ofsuch faunas in the fossil record is difficult to prove. The diversity of the machaeridian sclerites is high with different genera represented in different settings; it also seems to indicate a higher presence of machaeridians than what is shown at present.
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| 29. |
- Suzuki, R, et al.
(författare)
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Alcohol and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status : A prospective cohort study
- 2005
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Ingår i: Journal of the National Cancer Institute. - Karolinska Inst, Div Nutr Epidemiol, Natl Inst Environm Med, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden. Tokyo Metropolitan Komagome Hosp, Dept Surg & Breast Oncol, Tokyo Metropolitan Canc & Infect Dis Ctr, Tokyo, Japan. Harvard Univ, Sch Med, Boston, MA 02115 USA. Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA. : OXFORD UNIV PRESS INC. - 0027-8874 .- 1460-2105. ; 97:21, s. 1601-1608
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Tidskriftsartikel (refereegranskat)abstract
- Background: Alcohol intake has been reported to be positively associated with an increased risk of postmenopausal breast cancer; however, the association with the estrogen receptor (ER) and progesterone receptor (PR) status of the breast tumors remains unclear. Methods: Self-reported data on alcohol consumption were collected in 1987 and 1997 from 51847 postmenopausal women in the population-based Swedish Mammography Cohort. Through June 30,2004,1188 invasive breast cancer case patients with known ER and PR status were identified during an average 8.3-year follow-up. We used Cox proportional hazards models to estimate multivariable relative risks (RRs) of breast cancer, adjusting for age; family history of breast cancer; body mass index; height; parity; age at menarche, first birth, and menopause; education level; use of postmenopausal hormones; and diet. Heterogeneity among groups was evaluated using the Wald test. All statistical tests were two-sided. Results: Alcohol consumption was associated with an increased risk for the development of ER-positive (+) tumors, irrespective of PR status (highest intake [ >= 10 g of alcohol per day] versus nondrinkers, multivariable RR = 1.35, 95% confidence interval [CI] = 1.02 to 1.80; P-trend < .049 for ER+PR+ tumors; and RR = 2.36, 95% CI = 1.56 to 3.56; P-trend < .001 for ER+PR-tumors). The absolute rate of ER+ breast cancer (standardized to the age distribution of person-years experienced by all study participants using 5-year age categories) was 232 per 100000 person-years among women in the highest category of alcohol intake, and 158 per 100000 person-years among nondrinkers. No association was observed between alcohol intake and the risk of developing ER-tumors. Furthermore, we observed a statistically significant interaction between alcohol intake and the use of postmenopausal hormones on the risk for ER+PR+ tumors (P-interaction = .039). Conclusion: The observed association between risk of developing postmenopausal ER+ breast cancer and alcohol drinking, especially among those women who use postmenopausal hormones, may be important, because the majority of breast tumors among postmenopausal women overexpress ER.
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