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Common variants at 12q15 and 12q24 are associated with infant head circumference

Taal, H. Rob (author)
St Pourcain, Beate (author)
Thiering, Elisabeth (author)
show more...
Das, Shikta (author)
Mook-Kanamori, Dennis O. (author)
Warrington, Nicole M. (author)
Kaakinen, Marika (author)
Kreiner-Moller, Eskil (author)
Bradfield, Jonathan P. (author)
Freathy, Rachel M. (author)
Geller, Frank (author)
Guxens, Monica (author)
Cousminer, Diana L. (author)
Kerkhof, Marjan (author)
Timpson, Nicholas J. (author)
Ikram, M. Arfan (author)
Beilin, Lawrence J. (author)
Bonnelykke, Klaus (author)
Buxton, Jessica L. (author)
Charoen, Pimphen (author)
Chawes, Bo Lund Krogsgaard (author)
Eriksson, Johan (author)
Evans, David M. (author)
Hofman, Albert (author)
Kemp, John P. (author)
Kim, Cecilia E. (author)
Klopp, Norman (author)
Lahti, Jari (author)
Lye, Stephen J. (author)
McMahon, George (author)
Mentch, Frank D. (author)
Mueller-Nurasyid, Martina (author)
O'Reilly, Paul F. (author)
Prokopenko, Inga (author)
Rivadeneira, Fernando (author)
Steegers, Eric A. P. (author)
Sunyer, Jordi (author)
Tiesler, Carla (author)
Yaghootkar, Hanieh (author)
Breteler, Monique M. B. (author)
Debette, Stephanie (author)
Fornage, Myriam (author)
Gudnason, Vilmundur (author)
Launer, Lenore J. (author)
van der Lugt, Aad (author)
Mosley, Thomas H., Jr. (author)
Seshadri, Sudha (author)
Smith, Albert V. (author)
Vernooij, Meike W. (author)
Blakemore, Alexandra I. F. (author)
Chiavacci, Rosetta M. (author)
Feenstra, Bjarke (author)
Fernandez-Banet, Julio (author)
Grant, Struan F. A. (author)
Hartikainen, Anna-Liisa (author)
van der Heijden, Albert J. (author)
Iniguez, Carmen (author)
Lathrop, Mark (author)
McArdle, Wendy L. (author)
Molgaard, Anne (author)
Newnham, John P. (author)
Palmer, Lyle J. (author)
Palotie, Aarno (author)
Pouta, Annneli (author)
Ring, Susan M. (author)
Sovio, Ulla (author)
Standl, Marie (author)
Uitterlinden, Andre G. (author)
Wichmann, H-Erich (author)
Vissing, Nadja Hawwa (author)
DeCarli, Charles (author)
van Duijn, Cornelia M. (author)
McCarthy, Mark I. (author)
Koppelman, Gerard H. (author)
Estivill, Xavier (author)
Hattersley, Andrew T. (author)
Melbye, Mads (author)
Bisgaard, Hans (author)
Pennell, Craig E. (author)
Widen, Elisabeth (author)
Hakonarson, Hakon (author)
Smith, George Davey (author)
Heinrich, Joachim (author)
Jarvelin, Marjo-Riitta (author)
Jaddoe, Vincent W. V. (author)
Adair, Linda S. (author)
Ang, Wei (author)
Atalay, Mustafa (author)
van Beijsterveldt, Toos (author)
Bergen, Nienke (author)
Benke, Kelly (author)
Berry, Diane (author)
Coin, Lachlan (author)
Davis, Oliver S. P. (author)
Elliott, Paul (author)
Flexeder, Claudia (author)
Frayling, Tim (author)
Gaillard, Romy (author)
Groen-Blokhuis, Maria (author)
Goh, Liang-Kee (author)
Haworth, Claire M. A. (author)
Hadley, Dexter (author)
Hedebrand, Johannes (author)
Hinney, Anke (author)
Hirschhorn, Joel N. (author)
Holloway, John W. (author)
Holst, Claus (author)
Hottenga, Jouke Jan (author)
Horikoshi, Momoko (author)
Huikari, Ville (author)
Hypponen, Elina (author)
Kilpelainen, Tuomas O. (author)
Kirin, Mirna (author)
Kowgier, Matthew (author)
Lakka, Hanna-Maaria (author)
Lange, Leslie A. (author)
Lawlor, Debbie A. (author)
Lehtimaki, Terho (author)
Lewin, Alex (author)
Lindgren, Cecilia (author)
Lindi, Virpi (author)
Maggi, Reedik (author)
Marsh, Julie (author)
Middeldorp, Christel (author)
Millwood, Iona (author)
Murray, Jeffrey C. (author)
Mittuniversitetet,Institutionen för psykologi och socialt arbete
Nivard, Michel (author)
Nohr, Ellen Aagaard (author)
Ntalla, Ioanna (author)
Oken, Emily (author)
Panoutsopoulou, Kalliope (author)
Pararajasingham, Jennifer (author)
Rodriguez, Alina (author)
Mittuniversitetet,Institutionen för samhällsvetenskap (-2013)
Salem, Rany M. (author)
Sebert, Sylvain (author)
Siitonen, Niina (author)
Strachan, David P. (author)
Teo, Yik-Ying (author)
Valcarcel, Beatriz (author)
White, Scott (author)
Willemsen, Gonneke (author)
Zeggini, Eleftheria (author)
Boomsma, Dorret I. (author)
Cooper, Cyrus (author)
Gillman, Matthew (author)
Hocher, Berthold (author)
Lakka, Timo A. (author)
Mohlke, Karen L. (author)
Dedoussis, George V. (author)
Ong, Ken K. (author)
Pearson, Ewan R. (author)
Price, Thomas S. (author)
Power, Chris (author)
Raitakari, Olli T. (author)
Saw, Seang-Mei (author)
Scherag, Andre (author)
Simell, Olli (author)
Sorensen, Thorkild I. A. (author)
Wilson, James F. (author)
Schmidt, Reinhold (author)
Vrooman, Henri A. (author)
Sigurdsson, Sigurdur (author)
Ropele, Stefan (author)
Coker, Laura H. (author)
Longstreth, W. T., Jr. (author)
Niessen, Wiro J. (author)
DeStefano, Anita L. (author)
Beiser, Alexa (author)
Zijdenbos, Alex P. (author)
Struchalin, Maksim (author)
Jack, Clifford R., Jr. (author)
Nalls, Mike A. (author)
Au, Rhoda (author)
Gudnason, Haukur (author)
Harris, Tamara B. (author)
Meeks, William M. (author)
van Buchem, Mark A. (author)
Catellier, Diane (author)
Windham, B. Gwen (author)
Wolf, Philip A. (author)
Schmidt, Helena (author)
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 (creator_code:org_t)
2012-04-15
2012
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:5, s. 532-538
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Keyword

article; body height; brain growth; child; chromosome 12q; chromosome 12q15; chromosome 12q24; degenerative disease; disease association; female; gene locus; genetic association; genetic variability; head circumference; human; infant; infant head circumference; male; meta analysis; Parkinson disease; preschool child; priority journal; single nucleotide polymorphism

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Taal, H. Rob
St Pourcain, Bea ...
Thiering, Elisab ...
Das, Shikta
Mook-Kanamori, D ...
Warrington, Nico ...
show more...
Kaakinen, Marika
Kreiner-Moller, ...
Bradfield, Jonat ...
Freathy, Rachel ...
Geller, Frank
Guxens, Monica
Cousminer, Diana ...
Kerkhof, Marjan
Timpson, Nichola ...
Ikram, M. Arfan
Beilin, Lawrence ...
Bonnelykke, Klau ...
Buxton, Jessica ...
Charoen, Pimphen
Chawes, Bo Lund ...
Eriksson, Johan
Evans, David M.
Hofman, Albert
Kemp, John P.
Kim, Cecilia E.
Klopp, Norman
Lahti, Jari
Lye, Stephen J.
McMahon, George
Mentch, Frank D.
Mueller-Nurasyid ...
O'Reilly, Paul F ...
Prokopenko, Inga
Rivadeneira, Fer ...
Steegers, Eric A ...
Sunyer, Jordi
Tiesler, Carla
Yaghootkar, Hani ...
Breteler, Moniqu ...
Debette, Stephan ...
Fornage, Myriam
Gudnason, Vilmun ...
Launer, Lenore J ...
van der Lugt, Aa ...
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Seshadri, Sudha
Smith, Albert V.
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Chiavacci, Roset ...
Feenstra, Bjarke
Fernandez-Banet, ...
Grant, Struan F. ...
Hartikainen, Ann ...
van der Heijden, ...
Iniguez, Carmen
Lathrop, Mark
McArdle, Wendy L ...
Molgaard, Anne
Newnham, John P.
Palmer, Lyle J.
Palotie, Aarno
Pouta, Annneli
Ring, Susan M.
Sovio, Ulla
Standl, Marie
Uitterlinden, An ...
Wichmann, H-Eric ...
Vissing, Nadja H ...
DeCarli, Charles
van Duijn, Corne ...
McCarthy, Mark I ...
Koppelman, Gerar ...
Estivill, Xavier
Hattersley, Andr ...
Melbye, Mads
Bisgaard, Hans
Pennell, Craig E ...
Widen, Elisabeth
Hakonarson, Hako ...
Smith, George Da ...
Heinrich, Joachi ...
Jarvelin, Marjo- ...
Jaddoe, Vincent ...
Adair, Linda S.
Ang, Wei
Atalay, Mustafa
van Beijsterveld ...
Bergen, Nienke
Benke, Kelly
Berry, Diane
Coin, Lachlan
Davis, Oliver S. ...
Elliott, Paul
Flexeder, Claudi ...
Frayling, Tim
Gaillard, Romy
Groen-Blokhuis, ...
Goh, Liang-Kee
Haworth, Claire ...
Hadley, Dexter
Hedebrand, Johan ...
Hinney, Anke
Hirschhorn, Joel ...
Holloway, John W ...
Holst, Claus
Hottenga, Jouke ...
Horikoshi, Momok ...
Huikari, Ville
Hypponen, Elina
Kilpelainen, Tuo ...
Kirin, Mirna
Kowgier, Matthew
Lakka, Hanna-Maa ...
Lange, Leslie A.
Lawlor, Debbie A ...
Lehtimaki, Terho
Lewin, Alex
Lindgren, Cecili ...
Lindi, Virpi
Maggi, Reedik
Marsh, Julie
Middeldorp, Chri ...
Millwood, Iona
Murray, Jeffrey ...
Nivard, Michel
Nohr, Ellen Aaga ...
Ntalla, Ioanna
Oken, Emily
Panoutsopoulou, ...
Pararajasingham, ...
Rodriguez, Alina
Salem, Rany M.
Sebert, Sylvain
Siitonen, Niina
Strachan, David ...
Teo, Yik-Ying
Valcarcel, Beatr ...
White, Scott
Willemsen, Gonne ...
Zeggini, Elefthe ...
Boomsma, Dorret ...
Cooper, Cyrus
Gillman, Matthew
Hocher, Berthold
Lakka, Timo A.
Mohlke, Karen L.
Dedoussis, Georg ...
Ong, Ken K.
Pearson, Ewan R.
Price, Thomas S.
Power, Chris
Raitakari, Olli ...
Saw, Seang-Mei
Scherag, Andre
Simell, Olli
Sorensen, Thorki ...
Wilson, James F.
Schmidt, Reinhol ...
Vrooman, Henri A ...
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Ropele, Stefan
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Jack, Clifford R ...
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Au, Rhoda
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Nature Genetics
By the university
Mid Sweden University

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