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Premature menopause...
Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts
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- Vogt, Elinor Chelsom (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway
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- Real, Francisco Gómez (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
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- Husebye, Eystein Sverre (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway
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- Björnsdottir, Sigridur (författare)
- Karolinska Institutet
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- Benediktsdottir, Bryndis (författare)
- Medical Faculty, University of Iceland, Reykjavik, Iceland; Department of Sleep, Landspitali University Hospital Reykjavík, Reykjavik, Iceland
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- Bertelsen, Randi Jacobsen (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway
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- Demoly, Pascal (författare)
- University Hospital of Montpellier, IDESP, Univ Montpellier-Inserm, Montpellier, France
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- Franklin, Karl Anders (författare)
- Umeå universitet,Kirurgi
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- de Aja Gallastegui, Leire Sainz (författare)
- Unit of Epidemiology and Public Health, Department of Health, Basque Government, Vitoria-Gasteiz, Spain
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- González, Francisco Javier Callejas (författare)
- Department of Respiratory Medicine, Albacete University Hospital, Albacete, Spain
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- Heinrich, Joachim (författare)
- Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia
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- Holm, Mathias (författare)
- Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Jogi, Nils Oscar (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway
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- Leynaert, Benedicte (författare)
- Université Paris-Saclay, Inserm U1018, Center for Epidemiology and Population Health, Integrative Respiratory Epidemiology Team, Villejuif, France
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- Lindberg, Eva (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning,Department of Medical Sciences, Respiratory, Allergy and Sleep Medicine, Uppsala University, Uppsala, Sweden
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- Malinovschi, Andrei, 1978- (författare)
- Uppsala universitet,Klinisk fysiologi,Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
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- Martínez-Moratalla, Jesús (författare)
- Pneumology Service of the General University Hospital of Albacete, Albacete, Spain; Albacete Faculty of Medicine, Castilla-La Mancha University, Albacete, Spain
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- Mayoral, Raúl Godoy (författare)
- Department of Respiratory Medicine, Albacete University Hospital, Albacete, Spain
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- Oudin, Anna (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Pereira-Vega, Antonio (författare)
- Juan Ramón Jiménez University Hospital in Huelva, Huelva, Spain
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- Semjen, Chantal Raherison (författare)
- INSERM, EpiCene Team U1219, University of Bordeaux, Talence, France
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- Schlünssen, Vivi (författare)
- Department of Public Health, Environment, Work and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark; The National Research Center for the Working Environment, Copenhagen, Denmark
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- Triebner, Kai (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway
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- Øksnes, Marianne (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway
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Department of Clinical Science, University of Bergen, Bergen, Norway; KG. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway (creator_code:org_t)
- Bioscientifica, 2022
- 2022
- Engelska.
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Ingår i: Endocrine Connections. - : Bioscientifica. - 2049-3614. ; 11:5
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objective: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women.Design: Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-sectional analysis of 6870 women.Methods: Variables associated with the timing of menopause and hormone measurements of 17β-estradiol and follicle-stimulating hormone were explored using multivariable logistic regression analysis. Specific immunoprecipitating assays of steroidogenic autoantibodies against 21-hydroxylase (21-OH), side-chain cleavage enzyme (anti-SCC) and 17alpha-hydroxylase (17 OH), as well as NACHT leucine-rich-repeat protein 5 were used to identify women with likely autoimmune POI.Results: Premature menopause was identified in 2.8% of women, and these women had higher frequencies of nulliparity (37.4% vs 19.7%), obesity (28.7% vs 21.4%), osteoporosis (17.1% vs 11.6%), hormone replacement therapy (59.1% vs 36.9%) and never smokers (60.1% vs 50.9%) (P < 0.05), compared to women with menopause ≥40 years. Iatrogenic causes were found in 91 (47%) and non-ovarian causes in 27 (14%) women, while 77 (39%) women were classified as POI of unknown cause, resulting in a 1.1% prevalence of idiopathic POI. After adjustments nulliparity was the only variable significantly associated with POI (odds ratio 2.46; 95% CI 1.63-3.42). Based on the presence of autoantibodies against 21 OH and SCC, 4.5% of POI cases were of likely autoimmune origin.Conclusion: Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- autoimmune
- premature menopause
- premature ovarian failure
- premature ovarian insufficiency
- primary ovarian insufficiency
- Physiology
- Fysiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Vogt, Elinor Che ...
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Real, Francisco ...
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Husebye, Eystein ...
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Björnsdottir, Si ...
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Benediktsdottir, ...
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Bertelsen, Randi ...
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Demoly, Pascal
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Franklin, Karl A ...
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de Aja Gallasteg ...
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González, Franci ...
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Heinrich, Joachi ...
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Holm, Mathias
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Jogi, Nils Oscar
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Leynaert, Benedi ...
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Lindberg, Eva
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Malinovschi, And ...
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Martínez-Moratal ...
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Mayoral, Raúl Go ...
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Oudin, Anna
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Pereira-Vega, An ...
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Semjen, Chantal ...
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Schlünssen, Vivi
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Triebner, Kai
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Øksnes, Marianne
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- Artiklar i publikationen
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Endocrine Connec ...
- Av lärosätet
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Uppsala universitet
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Umeå universitet
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Karolinska Institutet