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Träfflista för sökning "WFRF:(Wallace D) srt2:(2000-2004)"

Sökning: WFRF:(Wallace D) > (2000-2004)

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  • Andersson, J., et al. (författare)
  • Pareto optimization using the struggle genetic crowding algorithm
  • 2002
  • Ingår i: Engineering optimization (Print). - : Informa UK Limited. - 0305-215X .- 1029-0273. ; 34:6, s. 623-643
  • Tidskriftsartikel (refereegranskat)abstract
    • Many real-world engineering design problems involve the simultaneous optimization of several conflicting objectives. In this paper, a method combining the straggle genetic crowding algorithm with Pareto-based population ranking is proposed to elicit trade-off frontiers. The new method has been tested on a variety of published problems, reliably locating both discontinuous Pareto frontiers as well as multiple Pareto frontiers in multi-modal search spaces. Other published multi-objective genetic algorithms are less robust in locating both global and local Pareto frontiers in a single optimization. For example, in a multi-modal test problem a previously published non-dominated sorting GA (NSGA) located the global Pareto frontier in 41% of the optimizations, while the proposed method located both global and local frontiers in all test runs. Additionally, the algorithm requires little problem specific tuning of parameters.
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  • Bruder, CEG, et al. (författare)
  • High resolution deletion analysis of constitutional DNA from neurofibromatosis type 2 (NF2) patients using microarray-CGH
  • 2001
  • Ingår i: Human Molecular Genetics. - Oxford, United Kingdom : Oxford University Press. - 0964-6906 .- 1460-2083. ; 1, s. 271-
  • Tidskriftsartikel (refereegranskat)abstract
    • Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder whose hallmark is bilateral vestibular schwannoma. It displays a pronounced clinical heterogeneity with mild to severe forms. The NF2 tumor suppressor (merlin/schwannomin) has been cloned and extensively analyzed for mutations in patients with different clinical variants of the disease. Correlation between the type of the NF2 gene mutation and the patient phenotype has been suggested to exist. However, several independent studies have shown that a fraction of NF2 patients with various phenotypes have constitutional deletions that partly or entirely remove one copy of the NF2 gene. The purpose of this study was to examine a 7 Mb interval in the vicinity of the NF2 gene in a large series of NF2 patients in order to determine the frequency and extent of deletions. A total of 116 NF2 patients were analyzed using high-resolution array-comparative genomic hybridization (CGH) on an array covering at least 90% of this region of 22q around the NF2 locus. Deletions, which remove one copy of the entire gene or are predicted to truncate the schwannomin protein, were detected in 8 severe, 10 moderate and 6 mild patients. This result does not support the correlation between the type of mutation affecting the NF2 gene and the disease phenotype. This work also demonstrates the general usefulness of the array-CON methodology for rapid and comprehensive detection of small (down to 40 kb) heterozygous and/or homozygous deletions occurring in constitutional or tumor-derived DNA.
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