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Träfflista för sökning "WFRF:(Weaver B) srt2:(2005-2009)"

Search: WFRF:(Weaver B) > (2005-2009)

  • Result 1-8 of 8
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1.
  • Birney, Ewan, et al. (author)
  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
  • 2007
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
  • Journal article (peer-reviewed)abstract
    • We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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2.
  • Adewumi, Oluseun, et al. (author)
  • Characterization of human embryonic stem cell lines by the International Stem Cell Initiative
  • 2007
  • In: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 25:7, s. 803-816
  • Journal article (peer-reviewed)abstract
    • The International Stem Cell Initiative characterized 59 human embryonic stem cell lines from 17 laboratories worldwide. Despite diverse genotypes and different techniques used for derivation and maintenance, all lines exhibited similar expression patterns for several markers of human embryonic stem cells. They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue- nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3. Nevertheless, the lines were not identical: differences in expression of several lineage markers were evident, and several imprinted genes showed generally similar allele-specific expression patterns, but some gene-dependent variation was observed. Also, some female lines expressed readily detectable levels of XIST whereas others did not. No significant contamination of the lines with mycoplasma, bacteria or cytopathic viruses was detected.
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  • Gössling, Stefan, et al. (author)
  • Synthesis and conclusions
  • 2009. - 1
  • In: Sustainable tourism futures. - London : Routledge. - 9780415996198 - 0415996198 ; , s. 299-306
  • Book chapter (peer-reviewed)
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  • Result 1-8 of 8
Type of publication
journal article (4)
book chapter (2)
editorial collection (1)
conference paper (1)
Type of content
peer-reviewed (7)
other academic/artistic (1)
Author/Editor
Weaver, D. (2)
Jacobs, P. (1)
Weaver, C. (1)
Martin, M. (1)
Mackey, J. (1)
Howell, A (1)
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Nikolaev, Sergey (1)
Lindblad-Toh, Kersti ... (1)
Colom, P. (1)
Antonarakis, Stylian ... (1)
Dermitzakis, Emmanou ... (1)
Estivill, Xavier (1)
Flicek, Paul (1)
Guigo, Roderic (1)
Valencia, Alfonso (1)
Adewumi, Oluseun (1)
Aflatoonian, Behrouz (1)
Ahrlund-Richter, Lar ... (1)
Amit, Michal (1)
Andrews, Peter W. (1)
Beighton, Gemma (1)
Bello, Paul A. (1)
Benvenisty, Nissim (1)
Berry, Lorraine S. (1)
Bevan, Simon (1)
Blum, Barak (1)
Brooking, Justin (1)
Chen, Kevin G. (1)
Choo, Andre B. H. (1)
Churchill, Gary A. (1)
Corbel, Marie (1)
Damjanov, Ivan (1)
Draper, Jon S. (1)
Dvorak, Petr (1)
Emanuelsson, Katarin ... (1)
Fleck, Roland A. (1)
Ford, Angela (1)
Gertow, Karin (1)
Gertsenstein, Marina (1)
Gokhale, Paul J. (1)
Hamilton, Rebecca S. (1)
Hampl, Ales (1)
Healy, Lyn E. (1)
Hovatta, Outi (1)
Hyllner, Johan (1)
Imreh, Marta P. (1)
Itskovitz-Eldor, Jos ... (1)
Jackson, Jamie (1)
Johnson, Jacqueline ... (1)
Jones, Mark (1)
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University
Lund University (4)
Uppsala University (2)
Linnaeus University (2)
Karolinska Institutet (2)
Royal Institute of Technology (1)
Stockholm University (1)
Language
English (8)
Research subject (UKÄ/SCB)
Social Sciences (4)
Natural sciences (1)
Medical and Health Sciences (1)

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