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Sökning: WFRF:(Worth A) > (2020-2021)

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1.
  • Grosche, S, et al. (författare)
  • Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
  • 2021
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 6618-
  • Tidskriftsartikel (refereegranskat)abstract
    • Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we investigate the role of rare variants in eczema susceptibility. We meta-analyze 21 study populations including 20,016 eczema cases and 380,433 controls. Rare variants are imputed with high accuracy using large population-based reference panels. We identify rare exonic variants in DUSP1, NOTCH4, and SLC9A4 to be associated with eczema. In DUSP1 and NOTCH4 missense variants are predicted to impact conserved functional domains. In addition, five novel common variants at SATB1-AS1/KCNH8, TRIB1/LINC00861, ZBTB1, TBX21/OSBPL7, and CSF2RB are discovered. While genes prioritized based on rare variants are significantly up-regulated in the skin, common variants point to immune cell function. Over 20% of the single nucleotide variant-based heritability is attributable to rare and low-frequency variants. The identified rare/low-frequency variants located in functional protein domains point to promising targets for novel therapeutic approaches to eczema.
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5.
  • Helvig, Sanne de Jong, et al. (författare)
  • A comparison of lab-scale free rotating wind turbines and actuator disks
  • 2021
  • Ingår i: Journal of Wind Engineering and Industrial Aerodynamics. - : Elsevier BV. - 0167-6105 .- 1872-8197. ; 209
  • Tidskriftsartikel (refereegranskat)abstract
    • Planar particle image velocimetry was conducted upstream and in the near-wake of a lab-scale free-rotating wind turbine model and compared to several actuator disks with the same dimensions. The Reynolds number of the incoming flow is order 10(4). Actuator disks with different designs and solidities were tested, and the process of actuator disk selection is explicitly shown. The drag, mean velocity and mean vorticity in the wake of the disks were compared to that of the rotating model. For the disk that was the best match, the Reynolds stresses and swirling strength are also presented. The instantaneous swirling strength illustrated that despite similar mean fields, the instantaneous phenomena were significantly different. Distinct tip vortices were present in the wake of the rotating model but were absent from the wake of the actuator disk. Proper orthogonal decomposition was used to further investigate the underlying phenomena in the two flows, again demonstrating the importance of tip vortices when studying the rotating model and the lack of such distinct vortices when using the actuator disk. Hence, despite well-matched mean characteristics, the instantaneous structures in the two flows remain distinct.
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