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Sökning: WFRF:(de Angelis Martin Hrabe) > (2010) > CIN85 regulates dop...

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice

Shimokawa, Noriaki (författare)
Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
Haglund, Kaisa (författare)
Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
Hölter, Sabine M (författare)
Institute of Developmental Genetics, Helmholtz Zentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg, Germany
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Grabbe, Caroline (författare)
Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
Kirkin, Vladimir (författare)
Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
Koibuchi, Noriyuki (författare)
Department of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma, Japan
Schultz, Christian (författare)
Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Goethe University, Frankfurt (Main), Germany
Rozman, Jan (författare)
Molecular Nutritional Medicine, Else-Kroner-Fresenius Center, Technische Universitat Munchen, Freising-Weihenstephan, Germany
Hoeller, Daniela (författare)
Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
Qiu, Chun-Hong (författare)
Department of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma, Japan
Londoño, Marina B (författare)
Department of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma, Japan
Ikezawa, Jun (författare)
Department of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma, Japan
Jedlicka, Peter (författare)
Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Goethe University, Frankfurt (Main), Germany
Stein, Birgit (författare)
Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
Schwarzacher, Stephan W (författare)
Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Goethe University, Frankfurt (Main), Germany,Institute of Developmental Genetics, Helmholtz Zentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg, Germany
Wolfer, David P (författare)
Institute of Anatomy, University of Zurich, and Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland
Ehrhardt, Nicole (författare)
Molecular Nutritional Medicine, Else-Kroner-Fresenius Center, Technische Universitat Munchen, Freising-Weihenstephan, Germany
Heuchel, Rainer (författare)
Karolinska Institutet,Uppsala universitet,Ludwiginstitutet för cancerforskning
Nezis, Ioannis (författare)
Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
Brech, Andreas (författare)
Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
Schmidt, Mirko H H (författare)
Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
Fuchs, Helmut (författare)
Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany
Gailus-Durner, Valerie (författare)
Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany
Klingenspor, Martin (författare)
Molecular Nutritional Medicine, Else-Kroner-Fresenius Center, Technische Universitat Munchen, Freising-Weihenstephan, Germany
Bogler, Oliver (författare)
Departments of Neurosurgery, Neuro-Oncology and Brain Tumor Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Wurst, Wolfgang (författare)
Institute of Developmental Genetics, Helmholtz Zentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg, Germany
Deller, Thomas (författare)
Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Goethe University, Frankfurt (Main), Germany
de Angelis, Martin Hrabé (författare)
Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany
Dikic, Ivan (författare)
Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt (Main), Germany
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 (creator_code:org_t)
2010-06-15
2010
Engelska.
Ingår i: EMBO Journal. - : European Molecular Biology Organization. - 0261-4189 .- 1460-2075. ; 29:14, s. 2421-2432
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Despite extensive investigations of Cbl-interacting protein of 85 kDa (CIN85) in receptor trafficking and cytoskeletal dynamics, little is known about its functions in vivo. Here, we report the study of a mouse deficient of the two CIN85 isoforms expressed in the central nervous system, exposing a function of CIN85 in dopamine receptor endocytosis. Mice lacking CIN85 exon 2 (CIN85(Deltaex2)) show hyperactivity phenotypes, characterized by increased physical activity and exploratory behaviour. Interestingly, CIN85(Deltaex2) animals display abnormally high levels of dopamine and D2 dopamine receptors (D2DRs) in the striatum, an important centre for the coordination of animal behaviour. Importantly, CIN85 localizes to the post-synaptic compartment of striatal neurons in which it co-clusters with D2DRs. Moreover, it interacts with endocytic regulators such as dynamin and endophilins in the striatum. Absence of striatal CIN85 causes insufficient complex formation of endophilins with D2DRs in the striatum and ultimately decreased D2DR endocytosis in striatal neurons in response to dopamine stimulation. These findings indicate an important function of CIN85 in the regulation of dopamine receptor functions and provide a molecular explanation for the hyperactive behaviour of CIN85(Deltaex2) mice.

Ämnesord

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Nyckelord

CIN85
dopamine receptor
endocytosis hyperactivity
synapse
MEDICINE
MEDICIN

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