SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

WFRF:(van der Pal Helena J.H.)
 

Search: WFRF:(van der Pal Helena J.H.) > (2024) > Cumulative Absolute...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Cumulative Absolute Risk of Subsequent Colorectal Cancer After Abdominopelvic Radiotherapy Among Childhood Cancer Survivors : A PanCareSurFup Study

Heymer, Emma J. (author)
University of Birmingham
Jóźwiak, Katarzyna (author)
Kremer, Leontien C. (author)
Princess Maxima Center for Pediatric Oncology/Hematology,Academic Medical Center of University of Amsterdam (AMC)
show more...
Winter, David L. (author)
University of Birmingham
de Vathaire, Florent (author)
Centre for Research in Epidemiology and Population Health (CESP)
Sunguc, Ceren (author)
University of Birmingham
Sugden, Elaine (author)
University of Birmingham
Kok, Judith L. (author)
Princess Maxima Center for Pediatric Oncology/Hematology
van der Pal, Helena J.H. (author)
Princess Maxima Center for Pediatric Oncology/Hematology
Hjorth, Lars (author)
Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
Jakab, Zsuzsanna (author)
Semmelweis University
Maule, Milena M. (author)
University of Turin
Haupt, Riccardo (author)
Gaslini Children's Hospital
Bagnasco, Francesca (author)
Gaslini Children's Hospital
Terenziani, Monica (author)
Istituto Nazionale dei Tumori
Diallo, Ibrahima (author)
Centre for Research in Epidemiology and Population Health (CESP)
Gunnes, Maria W. (author)
Norwegian Radium Hospital,Cancer Registry of Norway, Institute of Population-Based Cancer Research
Sommer, Grit (author)
University of Bern
Zaletel, Lorna Zadravec (author)
Institute of Oncology, Ljubljana
Kuehni, Claudia E. (author)
University of Bern,University Children's Hospital Bern
Winther, Jeanette F. (author)
Aarhus University Hospital,Danish Cancer Society
Lähteenmäki, Päivi M. (author)
Turku University Hospital
Gudmundsdottir, Thorgerdur (author)
National University Hospital of Iceland,Danish Cancer Society
Allodji, Rodrigue S. (author)
Centre for Research in Epidemiology and Population Health (CESP)
Skinner, Roderick (author)
University of Newcastle upon Tyne
Ronckers, Cécile M. (author)
Princess Maxima Center for Pediatric Oncology/Hematology,Carl von Ossietzky University of Oldenburg
Hawkins, Michael M. (author)
University of Birmingham
Reulen, Raoul C. (author)
University of Birmingham
Teepen, Jop C. (author)
Princess Maxima Center for Pediatric Oncology/Hematology
show less...
 (creator_code:org_t)
2024
2024
English 12 s.
In: Journal of Clinical Oncology. - 0732-183X. ; 42:3, s. 336-347
Related links:
http://dx.doi.org/10...
show more...
https://lup.lub.lu.s...
https://doi.org/10.1...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • PURPOSE Childhood cancer survivors are at the risk of developing subsequent colorectal cancers (CRCs), but the absolute risks by treatment modality are uncertain. We quantified the absolute risks by radiotherapy treatment characteristics using clinically accessible data from a Pan-European wide case-control study nested within a large cohort of childhood cancer survivors: the PanCareSurFup Study. METHODS Odds ratios (ORs) from a case-control study comprising 143 CRC cases and 143 controls nested within a cohort of 69,460 survivors were calculated. These, together with standardized incidence ratios for CRC for this cohort and European general population CRC incidence rates and survivors' mortality rates, were used to estimate cumulative absolute risks (CARs) by attained age for different categories of radiation to the abdominopelvic area. RESULTS Overall, survivors treated with abdominopelvic radiotherapy treatment (ART) were three times more likely to develop a subsequent CRC than those who did not receive ART (OR, 3.1 [95% CI, 1.4 to 6.6]). For male survivors treated with ART, the CAR was 0.27% (95% CI, 0.17 to 0.59) by age 40 years, 1.08% (95% CI, 0.69 to 2.34) by age 50 years (0.27% expected in the general population), and 3.7% (95% CI, 2.36 to 7.80) by age 60 years (0.95% expected). For female survivors treated with ART, the CAR was 0.29% (95% CI, 0.18 to 0.62) by age 40 years, 1.03% (95% CI, 0.65 to 2.22) by age 50 years (0.27% expected), and 3.0% (95% CI, 1.91 to 6.37) by age 60 years (0.82% expected). CONCLUSION We demonstrated that by age 40 years survivors of childhood cancer treated with ART already have a similar risk of CRC as those age 50 years in the general population for whom population-based CRC screening begins in many countries. This information should be used in the development of survivorship guidelines for the risk stratification of survivors concerning CRC risk.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view