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Sökning: hsv:(MEDICAL AND HEALTH SCIENCES) > Licentiatavhandling

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1.
  • Davet, Natalie, 1979 (författare)
  • "Jag har alla åldrar i mig!" : En studie om ålderns betydelser i kulturaktiviteter avsedda för barn, ungdomar och pensionärer
  • 2020
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • This study investigates the production of age in three state-funded intergenerational projects, intended to increase age integration between young and old citizens. The main aim of the study is to contribute to the production of knowledge about age as a social category and power system. The study is a small scale one year project which focuses on municipal intergenerational culture activities in one of Sweden’s larger cities. Three intergenerational projects within the fine arts (theater, literature and photography), were selected for the present study. The research questions are: How is age conditioned by the organization of the activity? How is age constructed through interactions within the participant group, and are there any circumstances in which age loses significance through the participants' interactions?, Which age norms become prominent through the activity? The study takes a social constructionist approach due to Vivien Burr. The theoretical framework is based on the theories of Michel Foucault, but also Judith Butler’s ideas about position to analyze how age is constructed. The theoretical discussion relates to the emerging research field of critical age studies, connecting childhood and youth studies with the research field of social gerontology. The results show that age is made significant in different ways. The organized encounters and everyday interactions between young and old participants are regulated through the idea of age difference between young and old. The study shows that the participants are given different conditions and obligations based on both gender and age-related norms concerning freedom, control, technical knowledge, vulnerability, care needs, responsibility, agility and adaptability. The intergenerational activities appear to be organized in a tradition where adulthood becomes the dominant age norm that seems to lack any need for integration. The activities therefore put adulthood in a vague but at the same time superior position in relation to other age groups. On an age-related level, it is apparent that the ages of children, adolescents and the elderly are marked in relation to adulthood.
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2.
  • Erichsén, Eva, 1959- (författare)
  • Constipation in palliative care : Prevalence, definitions, symptom distress and risk-factors
  • 2015
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Background and aims: Constipation for patients in palliative care is common and described with variations in prevalence. Side -effects from opioid- treatment, is considered to be one of the main factors leading to constipation. The overall aim of the thesis was to study constipation among patients admitted to specialized palliative care- settings in Sweden. The specific aims of the thesis were 1) To describe and explore the prevalence, definition and symptom distress of constipation by applying different definitions of constipation, in patients admitted to specialized palliative care settings in Sweden. 2) To identify factors related to constipation in patients in specialized palliative care and comparing these factors for patients with different types of constipation to patients without constipation.Methods: A literature- search were conducted where prevalence of- and factors related to constipation was explored and included in a questionnaire, developed for this thesis. Data was collected in a cross- sectional design with a response rate of 50% and analysed with logistic regression.Results: A total of 485 patients from 38 specialized palliative care- units in Sweden participated. Prevalence of constipation for patients in specialized palliative care varied between 7- 43 % depending on definition used. Two different constipation- groups were identified: Medical constipation- group 23% (MCG) and Perceived constipation- group 35% (PCG). Three sub- groups was also identified: patients with i) only ≤ 3 defecations/week, 7%, ii) only perception of being constipated, 19%, and iii) patients with both ≤ 3 defecations/ week and perception of being constipated,16%. Several factors were found to be related to constipation as hospitalisation, absence of laxative- treatment, haemorrhoids, poor appetite, hard stool form and opioids.Conclusions: Prevalence of constipation may differ depending on definitions used. Distress from constipation and other factors related to constipation, than opioids, needs to be incorporated into the clinical constipation- assessment. Validated constipation assessment tool needs to be developed.
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3.
  • Holmström, Paul, 1948 (författare)
  • Bringing System Dynamics into Action Research
  • 2017
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • System Dynamics simulation is a computer-aided approach to policy analysis and design, often carried out by external experts in simulation. System Dynamics is particularly useful in complicated and complex situations, such as healthcare. However, research has shown that few models in healthcare are implemented.Within System Dynamics there are methods for group model building or participatory modelling, where simulation models generate insights for organizational learning. The aim of this thesis is to study how System Dynamics can be a useful tool for healthcare practitioners in action research settings, building more on the needs and issues of a group.Thirteen cases are described in detail to illustrate the what is similar and different from a process / action research perspective, so that general conclusions can be made.The thesis concludes that action research approaches are useful when more time is spent on initial stages identifying issues relevant to the participants. Using Causal Loop Diagrams creates shared maps and understanding of how issues are connected. The shared understanding is increased through experimentation and learning from simulation models so that the group can converge on solutions that they agree on and thus lower the threshold for implementation.
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5.
  • Lendaro, Eva, 1989 (författare)
  • On the use of Phantom Motor Execution for the treatment of Phantom Limb Pain
  • 2020
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Phantom limb pain (PLP) is a common complaint among amputees and despite having been studied for centuries, it remains a mysterious object of debate among researcher. To date, a vast number of ways to treat PLP has been proposed in the literature, however none of them has proven to be universally effective, thus creating uncertainty on how to operate clinically. The uncertainty is largely attributable to the scarcity of well conducted randomized controlled trials (RCTs) to prove the efficacy of PLP treatments. Phantom Motor Execution (PME) -exertion of voluntary phantom limb movements – aims at restoring the control over the phantom limb and the exercise of such control has been hypothesized to reverse neural changes implicated in PLP. Preliminary evidence supporting this hypothesis has been provided by clinical investigations on upper limb amputees. The main purpose of this Licentiate thesis was to enable a RCT on the use of PME for the treatment of PLP in order to provide robust and unbiased evidence for clinical practice. However, the implementation and kick-off of this clinical investigation required to complete few preparatory steps. For example, most amputees and PLP patients have lower limb amputation, thus PME needed to be adapted and validated for this population. Further, the RCT protocol needed to be carefully planned and made openly accessible, as per guidelines for conducting and publishing clinical RCT. Finally, a secondary aim of this thesis emerged with the need of providing long term relief from PLP to patient. Preliminary evidence seemed to indicate that in order to maintain pain relief, periodic rehearsal of the phantom motor skills acquired through PME is necessary. This raised the question of whether it is beneficial and possible to translate the technology from clinic to home use, question that was explored employing both quantitative and qualitative methods from engineering, medical anthropology, and user interface design. The work conducted within this thesis resulted in the extension of PME to lower limb patients by proposal and validation of a new and more user-friendly recording configuration to record EMG signals. The use of PME was then shown to be efficacious in relieving PLP with a case study on a patient. The protocol for the RCT was then designed and published. These two first steps permitted the establishment of the RCT, which is currently ongoing and expected to close in March 2021. With regard to the secondary aim of this thesis, the work conducted enabled PME to be used by the patients in the comfort of their home, while it also allowed investigate the benefits and challenges generally faced (not only by PME) in the transition from the clinic to home and its effects on treatment adherence. The work conducted is presented in the three appended publications. Future work includes the presentation of the results of the RCT. Further, having a way to modulate PLP is an incredibly useful tool to study the neural basis of PLP. By capitalizing on this tool, we are currently conducting brain imaging studies using fMRI and electroencephalography that are the main focus of the work that lies ahead.
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6.
  • Lindgren, Anne (författare)
  • Pregnancy-related low back and pelvic girdle pain : with reference to joint hypermobility and treatment
  • 2020
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Objectives: To explore if joint mobility, as a measure of connective tissue quality, could be a predictor for pregnancy-related low back pain after pregnancy and to evaluate local corticosteroid injection treatment in women with persistent pelvic girdle pain long after childbirth.Material and methods: To investigate joint mobility in relation to pain, 200 women were examined repeatedly from early pregnancy until three months after delivery. Their mobility in left fourth finger abduction in early pregnancy was compared with clinically assessed low back and pelvic pain 3 months after delivery. To evaluate local corticosteroid injection treatment, 36 women with persistent PGP were included in a randomised controlled trial (RCT) and randomised to either corticosteroid injection or saline injection on one occasion at the ischial spine bilaterally, with a follow-up after four weeks. In both studies, the women were asked about obstetric history, to complete a pain drawing, estimate their level of pain on a visual analogue scale (0-100) and estimate how they manage their everyday activities on a questionnaire, Disability Rating Index (DRI). In the RCT, the 36 women also completed Short Form 36 (SF-36), a quality of life questionnaire, six-minute walk test (6MWT), and isometric trunk flexion and extension were examined.Results: Women with low back and pelvic pain three months after pregnancy had increased finger laxity in early pregnancy. The larger the finger angle and the more pregnancies, the greater the risk of low back and pelvic pain after pregnancy. In the RCT, at follow-up, the women who received corticosteroid injection treatment improved in walking ability, estimated physical ability and isometric trunk extension more than those who received saline injections.Conclusions: Increased joint mobility, as measured by finger joint mobility, together with the number of previous pregnancies, may be an indicator of low back and pelvic pain postpartum. One single corticosteroid injection treatment to intra-pelvic structures improved function in women with persistent PGP which may indicate a source of pain.
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7.
  • Lundgren, Dan (författare)
  • Ledarskap och psykosocial arbetsmiljö i kommunal äldreomsorg : Skillnader och likheter mellan särskilt boende och hemtjänst
  • 2015
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Introduction. Municipal eldercare is increasingly multifaceted. First line managers in nursing homes and home help services are responsible for personnel, budget and processes. The resources and work conditions of these managers have changed over time. The first line manager is often responsible not only for economic but also for quality development of their unit. Research focusing on first line management within municipal eldercare is lacking in specific contexts, for example, research on leadership in nursing homes and home help services.Aims. The aim of this thesis is to study and analyze perceptions of leadership in eldercare. The main objective is to analyze differences in leaders’ and nursing assistants’ perceptions of leadership in nursing homes and home help services, and to study leadership factors and their associations with psychosocial work environment among nursing assistants who are engaged in eldercare.Design and methods. This thesis is based on two studies, and uses cross-sectional data from two different surveys: the Developmental Leadership Questionnaire, DLQ (Larsson, 2006a) and a Questionnaire for Psychological and Social factors at Work, QPS, (Dallner, et al.,2000). Assessments from 21 leaders and 95 nursing assistants in nursing homes and home help services were analyzed in study I. Assessments from 1132 nursing assistants in nursing homes and in home help services (n=844 nursing homes and n=288, home help service units) were analyzed in article II. The data were analyzed with descriptive and analytic statistics.Results. Nursing assistants in nursing homes assessed their leaders to be more controlling and observant than nursing assistants in home help services. According the leaders self assessment, leaders in home help services were less successful at being supportive, being a good example, and promoting creativity than leaders in nursing homes. Psychosocial work environment was related to leadership factors, but stronger associations occurred more frequently in nursing homes than in home help services. The leadership factors empowering leadership, support from superiors, focus on human resources and control over decisions were associated with better results on all the variables that were related to the psychosocial work environment in both nursing homes and in home help services.Conclusions and implications for practice. Organisational differences in conducting leadership in old age care must be considered. Some leadership characteristics are better conditions for creating and maintaining a positive psychosocial work environment for nursing assistants in nursing homes and home help services. Due to the differences in organisational settings, it is important to consider the differences in conditions for conducting leadership. To influence nursing assistants’ performance and to increase quality in eldercare in the long term, appropriate leadership is necessary. Therefore, it is important for the leaders to provide support in work, help to develop skills, encourage employees to participate in important decisions, and show interest in nursing assistants’ well-being. Also, the leaders might benefit if they reduce the specialisation of work, which counteracts the possibility to have variation in work in nursing homes and home help services. In particular, nursing homes should benefit if they reduce the amount of role conflicts, and if nursing assistants receive reasonable quantitative work demands. The municipality eldercare should take into account the organisational differences in conducting leadership in nursing homes in relation to home help services. Recruiting leaders with characteristics that are desirable in the specific context will create better conditions for a good psychosocial work environment in nursing homes and home help services.
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8.
  • Thunander Sundbom, Lena, 1970- (författare)
  • The influence of gender and psychological distress on adherence to prescribed medication
  • 2014
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Background: The lack of adherence to drug therapy is a major problem; it can contribute to significant deterioration of disease and increased health-care costs. Improving medication adherence is a big challenge; there is no simple solution to the problem. It is thus essential to improve our knowledge of non-adherence (NA) and its causes.Aims: The aims of the thesis were to study the influence of gender and psychological distress on self-reported, intentional and unintentional non-adherent behaviour, and to investigate the reasons for NA.Methods: A population-based study that included a postal questionnaire was carried out in a cross-section of the general Swedish population (n=7,985, aged 18-84 years). The response rate was 61.1% (n=4,875) and current prescription drug use was reported by 2,802 participants. The questionnaire covered use of prescription drugs, NA to the drug regimens, reasons for NA, economic status, attitudes to drugs, and the presence of somatic or mental problems, and also included the Hospital Anxiety and Depression Scale questionnaire.Results: The results showed differences in various self-reported non-adherent behaviour patterns and reasons for NA between the genders. In most cases, these remained after controlling for confounders such as socioeconomic factors and attitudes to drugs that are known to differ between women and men. Associations were also found between symptoms of anxiety and/or depression and the presence of intentional or unintentional non-adherent behaviour (with a stronger average association for intentional NA), and between anxiety/depression and some of the reasons given for NA, e.g. adverse drug reactions (ADRs).Conclusions: Although it was not possible to confirm causal relationships, this thesis emphasises the effects of gender and psychological distress on NA. In summary, both gender and anxiety and/or depression influenced non-adherent behaviour and the reasons given for NA. For instance, ADRs seemed to influence the decision not to take the drug as prescribed, especially among women and participants under psychological distress. It is suggested that a deep understanding of the causes of NA and of the impact of gender and psychological distress on the outcomes would help those aiming to improve adherence to prescribed medication.
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9.
  • Deyhle Jr, Richard (författare)
  • Cross-modal Imaging in Lung Research: From µCT dosimetry to synchrotron phase contrast microtomography biomechanical insights in preclinical lung injury models
  • 2024
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Lung diseases continue to present a large burden to public health, especially in industrialized countries. For abetter understanding of the underlying patho-mechanisms in lung related diseases as well as for testing theefficacy of novel therapies, preclinical studies in animal models are indispensable. The significance of preclinical X-ray based micro-computed tomography (µCT) research lies in its ability to provide high-resolution, non-invasive lung imaging of small animals as the air inside the lung acts as a natural contrast and to image the lung parenchyma longitudinally to assess functional and morphological alterations and test efficacy of therapeutic interventions. This often requires requires imaging protocols that balance between sufficient image quality and clinically relevant radiation absorbed doses. A reproducible method for evaluation of absorbed radiation absorbed doses is desirable. Absorbed radiation absorbed doses were measured in a polymethyl methacrylate (PMMA) phantom using standard TLD and a novel type of OSLD made form household salt. Four imaging protocols from MILabs “xUHR-µCT” scanner were tested. A large discrepancy was observed from results compared to vendor-provided values. The results indicate a need for thorough empirical dose measurements prior to performing longitudinal studies. Four-dimensional imaging, allows for investigation of the dynamics of regional lung functional parameters simultaneously with structural deformation of the lung as a function of time. It is of significant interest to have direct visualization and quantification of interstitial lung diseases at spatial resolutions beyond the capabilities of clinical and conventional absorption-based only CT. Thus far, the high intensity of synchrotron X-ray light sources offer a tool to investigate dynamic morphological and mechanistic features, enabling dynamic in-vivo microscopy. This investigation elucidates the direct effects of interventions targeting the pathophysiology of Acute Respiratory Distress Syndrome (ARDS) and Ventilator-Induced Lung Injury (VILI) on the terminal airways and alveolar microstructure within intact lungs. In such conditions, the relationship between microscopic strain within the mechanics of the alveolar structure and the broader mechanical characteristics and viscoelastic properties of the lungs remains poorly understood. A time-resolved synchrotron phase-contrast micro-computed tomography imaging acquisition protocol based on the synchronization between the mechanical ventilation and the cardiac activity was used to resolve the lung parenchyma motion with an effective isotropic voxel size of 6 µm. Quantitative maps of microscopic local lung tissue strain within aerated lung alveolar tissue under protective mechanical ventilation in anesthetized rats were obtained. This approach was used to assess the effect of alterations in lung tissue biomechanics induced by lung injury at 7 days after single-dose, intratracheal bleomycin instillation in combination with short-term high-tidal volume (VT) mechanical ventilation. Overall, this work address the aspects of radiation exposure to in experimental imaging of small animals and lays a foundation for a more nuanced understanding of lung injury and mechanical ventilation. In the future, it may result in a more effective and less injurious respiratory support for patients with acute lung injury or chronic lung diseases.
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10.
  • Erici, Sten (författare)
  • Challenging patient communication in a medical education curriculum - Perspectives on learning with simulated patients
  • 2023
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Being able to manage challenging patient communication and the associated emotional burden is a vital skill for physicians that is regularly utilized in clinical work. Therefore, it is reasonable that medical students get the opportunity to acquire and develop the relevant knowledge and skills related to challenging patient communication during their education. Simulated patient scenarios are useful learning activities known to improve the managing of challenging patient communication. Understanding student and teacher perceptions of vital communicative strategies and how to effectively organize learning activities, including simulated patients, within the curriculum, can enhance students' communicative progression.The aim of this thesis is to explore perceptions of learning in a simulated patient scenario from three different perspectives: students, simulated patients, and teachers. Additionally, we aim to examine the communicative approaches perceived as vital to manage challenging patient communication and how they are learned from a programme perspective. Furthermore, we seek to explore the relationship between patient simulation and adjacent learning activities.A qualitative approach was applied. Individual interviews and a narrative survey were conducted with students, teachers, and a simulated patient as part of two separate studies during the 9th semester of a medical programme. Curriculum documents served as a framework.Our findings indicate that simulated patients in learning how to manage challenging patient communication is perceived beneficial for developing professional identity and self-knowledge. It is crucial that the learning activity enables student centred learning, supported by flexible simulated patients. Self-knowledge and the ability to convey empathy is perceived as essential in handling challenging patient communication. The organization of learning activities is perceived to be enhanced by interweaving activities related to learning medical knowledge and patient communication, including simulated patients.
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