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- Wickbom, Anna, 1970-, et al.
(författare)
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Ischemisk kolit
- 2012
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Ischemisk kolit är den vanligaste formen av intestinal ischemi. Tillståndet omfattar ett kliniskt spektrum från mild, övergående mukosaischemi (ca 80-85% av fallen) till potentiellt livshotande transmuralt tarmgangrän (ca 15%). Kolon sigmoideum, descendens och vänster flexur är oftast drabbade (75%) medan rektum vanligtvis inte är afficierad. Denna utbredning förklaras av att proximala kolon får sin blodförsörjning via a. mesenterica superior och kolon descendens och sigmoideum via a. mesenterica inferior medan rektum får sin blodförsörjning även via grenar från a. iliaca interna. Området, där de två mesenterialkärlen möts, är hemodynamiskt vulnerabelt med stor variation avseende utvecklade kollateraler. Sjukdomen förekommer framför allt hos äldre personer, men kan ses även hos yngre.
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| 3. |
- Wong, Sui-Weng, et al.
(författare)
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Development of Steatohepatitis and Fibrosis in Chronic HBV Infection Is Linked to Inflammatory Responses Mediated by IL-13 and CCL11
- 2019
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Ingår i: SSRN Electronic Journal. - : Elsevier BV. - 1556-5068.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: In view of the importance of chronic HBV (CHB) infection and the global burden of non-alcoholic fatty liver disease (NAFLD), it is imperative to understand the potential interplay between the two diseases.Methods: Here, we retrospectively investigated the association between NAFLD and CHB infection in the context of liver fibrosis. Among the 522 consecutive CHB patients who underwent transient elastography between year 2013 and 2016, we studied 449 subjects in the current investigation.Findings: CAP and LSM scores were generally higher in patients with steatosis and fibrosis or cirrhosis. Antiviral treatment had significantly reduced the HBV viral load. Other liver function markers showed a significant positive correlation with both CAP and LSM scores. Plasma IL-13 was independently associated with increased CAP score where every increase of 1 unit of IL-13 was associated with an increase in CAP score by 0.98 unit. CCL11 was independently associated with LSM with every increase of CCL11 by a unit that, in turn, was associated with an increase of LSM score.Interpretations: Together, we found that there was a high concurrence of NAFLD among patients with CHB. The presence of metabolic syndrome and chronic inflammation in CHB patients were two independent factors that led to progression of liver cirrhosis, with IL-13 playing the key role in linking the metabolic with the inflammatory components. Plasma markers of liver steatosis and fibrosis progression are key to development of cell-targeted therapies exploiting specific molecular pathways.
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