| 1. |
- Albinsson, John, et al.
(författare)
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Combined use of Iteration, Quadratic Interpolation and an Extra Kernel for high-resolution 2D particle tracking : a first evaluation
- 2010
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Ingår i: 2010 ieee international ultrasonics symposium. - New York : IEEE Press. - 9781457703829 ; , s. 2000-2003
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Konferensbidrag (refereegranskat)abstract
- A novel 2D particle tracking method, that uses 1) iteration, 2) fast quadratic sub-pixel estimation (with only 28 multiplications per movement), and 3) a previous kernel, has been evaluated and compared with a full-search block-matching method. The comparison with high-frequency ultrasound data (40 MHz) was conducted in silico and on phantoms, which comprised lateral, diagonal, and ellipsoidal movement patterns with speeds of 0–15 mm/s. The mean tracking error was reduced by 68% in silico and 71% for the phantom measurements. When only sub-pixel estimation was used, the decrease in the tracking error was 61% in silico and 57% for the phantom measurements. As well as decreasing the tracking error, the new method only used 70% of the computational time needed by the full-search block-matching method. With a fast method having good tracking ability for high-frequency ultrasound data, we now have a tool to better investigate tissue movements and its dynamic functionality.
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| 2. |
- Geng, H., et al.
(författare)
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Incomplete B cell tolerance to cartilage oligomeric matrix protein in mice
- 2013
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Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 65:9, s. 2301-2309
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Cartilage oligomeric matrix protein (COMP) is a major noncollagenous component of cartilage and is used as a biomarker in rheumatoid arthritis and experimental arthritis. Injection of COMP leads to severe inflammatory joint disease, and antibodies play a critical role in mediating arthritis. The arthritogenicity of COMP might be due to the lack of self tolerance. This study was undertaken to determine the status of COMP-specific B cell tolerance using COMP-deficient mice. METHODS: Arthritis development and antibody responses were compared between COMP-sufficient and COMP-deficient littermates after immunization with rat COMP. Serum anti-COMP antibody levels were measured using a panel of recombinant mouse COMP proteins, and antibody-secreting cells were enumerated by enzyme-linked immunospot assays. A novel sandwich enzyme-linked immunosorbent assay was developed to assess COMP molecules in serum. RESULTS: COMP-sufficient mice, but not COMP-deficient mice, developed severe arthritis following immunization with rat COMP. However, anti-COMP antibody titers to native COMP and recombinant protein domains covering the entire mouse COMP sequence, except the less immunodominant type 3 repeat domains, were decreased in COMP-sufficient mice compared to COMP-deficient mice. In addition, COMP-sufficient mice had fewer B cells secreting COMP-reactive antibodies. Detectable levels of full-length COMP in arthritic COMP-sufficient B10.Q NCF-1(*/*) and healthy mice suggested systemic availability of COMP to the immune system. CONCLUSION: The lack of arthritis, together with high levels of COMP-specific antibodies, in COMP-deficient mice indicates that susceptibility to arthritis is COMP specific and that endogenous expression of COMP in wild-type mice tolerizes B cells in vivo.
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| 3. |
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| 4. |
- Li, Ping, et al.
(författare)
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Sparse regularized joint projection model for identifying associations of non-coding RNAs and human diseases
- 2022
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Ingår i: Knowledge-Based Systems. - Amsterdam : Elsevier. - 0950-7051 .- 1872-7409. ; 258
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Tidskriftsartikel (refereegranskat)abstract
- Current human biomedical research shows that human diseases are closely related to non-coding RNAs, so it is of great significance for human medicine to study the relationship between diseases and non-coding RNAs. Current research has found associations between non-coding RNAs and human diseases through a variety of effective methods, but most of the methods are complex and targeted at a single RNA or disease. Therefore, we urgently need an effective and simple method to discover the associations between non-coding RNAs and human diseases. In this paper, we propose a sparse regularized joint projection model (SRJP) to identify the associations between non-coding RNAs and diseases. First, we extract information through a series of ncRNA similarity matrices and disease similarity matrices and assign average weights to the similarity matrices of the two sides. Then we decompose the similarity matrices of the two spaces into low-rank matrices and put them into SRJP. In SRJP, we innovatively use the projection matrix to combine the ncRNA side and the disease side to identify the associations between ncRNAs and diseases. Finally, the regularization term in SRJP effectively improves the robustness and generalization ability of the model. We test our model on different datasets involving three types of ncRNAs: circRNA, microRNA and long non-coding RNA. The experimental results show that SRJP has superior ability to identify and predict the associations between ncRNAs and diseases. © 2022 The Author(s)
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| 5. |
- Stevens, DR, et al.
(författare)
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Cycloheximide resistance conferred by novel mutations in ribosomal protein L41 of Chlamydomonas reinhardtii
- 2001
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Ingår i: Molecular General Genetics. - Berlin : Springer-Verlag. - 0026-8925 .- 1432-1874. ; 264:6, s. 790-795
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Tidskriftsartikel (refereegranskat)abstract
- Although most eukaryotic cells are sensitive to the 80S ribosome inhibitor cycloheximide (CYH), naturally occurring CYH resistance is widespread amongst yeast species. The primary determinant of resistance appears to be a single residue within ribosomal protein L41; resistance is acquired by the substitution of a conserved proline (P-56) by a glutamate residue. We have isolated the L41 gene (RPL41) from the green alga Chlamydomonas and investigated the molecular basis of CYH resistance in various mutant strains. In both the wild-type strain and the mutant act-1, a proline is found at the key position in L41.; However, analysis of six independently isolated act-2 mutants reveals that all have point mutations that replace the proline with either leucine or serine. Of the two changes, the leucine mutation confers significantly higher levels of CYH resistance. This work identifies the ACT-2 locus as RPL41 and provides a possible dominant marker for nuclear transformation of C. reinhardtii.
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| 6. |
- Guo, Xiaoyi, et al.
(författare)
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Subspace projection-based weighted echo state networks for predicting therapeutic peptides
- 2023
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Ingår i: Knowledge-Based Systems. - Amsterdam : Elsevier. - 0950-7051 .- 1872-7409. ; 263
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Tidskriftsartikel (refereegranskat)abstract
- Detection of therapeutic peptide is a major research direction in the current biopharmaceutical field. However, traditional biochemical experimental detection methods take a lot of time. As supplementary methods for biochemical experiments, the computational methods can improve the efficiency of therapeutic peptide detection. Currently, most machine learning-based therapeutic peptide identification algorithms do not consider the processing of noisy samples. We propose a therapeutic peptide classifier, called weighted echo state networks based on subspace projection (WESN-SP), which reduces the bias caused by high-dimensional noisy features and noisy samples. WESN-SP is trained by sparse Bayesian learning algorithm (SBL) and introduces a weight coefficient for each sample by kernel dependence maximization-based subspace projection. The experimental results show that WESN-SP has better performance than other existing methods. © 2023 The Author(s). Published by Elsevier B.V.
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| 7. |
- Hedenberg, Klas, 1968-, et al.
(författare)
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Obstacle Detection For Thin Horizontal Structures
- 2008
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Ingår i: World Congress on Engineering and Computer Science. - Hong Kong : International Association of Engineers. - 9789889867102 ; , s. 689-693
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Konferensbidrag (refereegranskat)abstract
- Many vision-based approaches for obstacle detection often state that vertical thin structure is of importance, e.g. poles and trees. However, there are also problem in detecting thin horizontal structures. In an industrial case there are horizontal objects, e.g. cables and fork lifts, and slanting objects, e.g. ladders, that also has to be detected. This paper focuses on the problem to detect thin horizontal structures. The system uses three cameras, situated as a horizontal pair and a vertical pair, which makes it possible to also detect thin horizontal structures. A comparison between a sparse disparity map based on edges and a dense disparity map with a column and row filter is made. Both methods use the Sum of Absolute Difference to compute the disparity maps. Special interest has been in scenes with thin horizontal objects. Tests show that the sparse dense method based on the Canny edge detector works better for the environments we have tested.
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| 8. |
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| 9. |
- Stasiunas, Antanas, et al.
(författare)
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Compression, adaptation and efferent control in a revised outer hair cell functional model
- 2005
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Ingår i: Medical Engineering and Physics. - Amsterdam : Elsevier. - 1350-4533 .- 1873-4030. ; 27:9, s. 780-789
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Tidskriftsartikel (refereegranskat)abstract
- In the cochlea of the inner ear, outer hair cells (OHC) together with the local passive structures of the tectorial and basilar membranes comprise non-linear resonance circuits with the local and central (afferent–efferent) feedback. The characteristics of these circuits and their control possibilities depend on the mechanomotility of the OHC. The main element of our functional model of the OHC is the mechanomotility circuit with the general transfer characteristic y = k tanh(x − a). The parameter k of this characteristic reflects the axial stiffness of the OHC, and the parameter a working position of the hair bundle. The efferent synaptic signals act on the parameter k directly and on the parameter a indirectly through changes in the membrane potential. The dependences of the sensitivity and selectivity on changes in the parameters a and k are obtained by the computer simulation. Functioning of the model at low-level input signals is linear. Due to the non-linearity of the transfer characteristic of the mechanomotility circuit the high-level signals are compressed. For the adaptation and efferent control, however, the transfer characteristic with respect to the initial operating point should be asymmetrical (a > 0). The asymmetry relies on the deflection of the hair bundle from the axis of the OHC.
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| 10. |
- Stålhammar, Anna, et al.
(författare)
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Policies for labour management - existence and content
- 2008
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Ingår i: Scandinavian Journal of Caring Sciences. - : Blackwell Publishing. - 0283-9318 .- 1471-6712. ; 22:2, s. 259-264
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: To prevent dystocia, it is important to have criteria for labour onset and policies for diagnosing and treating uterine inertia. Uterine inertia is often followed by complications such as prolonged labour, caesarean section, instrumental labour and a negative birth experience, and prevention and proper treatment are therefore important. The Swedish National Board of Health and Welfare has stipulated that labour wards should have policies for labour management. The aim of this study was to investigate the extent to which labour wards in Sweden have such policies. For those wards with policies for labour management, a further aim was to study the content of the policies. METHODS: A descriptive survey presenting information from 48 of 49 labour wards in Sweden. Descriptive statistics were used. RESULTS: Three of the 48 labour wards had written policies concerning all four main issues of interest. Written policies existed regarding criteria for labour onset at 11 wards, diagnosis of uterine inertia at 13 wards and treatment of uterine inertia at 21 wards. Seventeen wards had written policies for when during the progress of labour neuraxial analgesia was recommended. CONCLUSIONS: The majority of labour wards in Sweden did not have written policies, and there was no consensus among the wards regarding criteria for diagnosing labour onset and uterine inertia, policies for treatment of uterine inertia, or about recommendations for when to use neuraxial analgesia. It is possible that the lack of policies could imply a risk for nonevidence-based labour management.
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