1. |
|
|
2. |
- Andersson, Ingemar, 1950-
(författare)
-
Rehabilitering vid långvarig smärta
- 2010. - 2
-
Ingår i: Smärta och smärtbehandling. - Stockholm : Liber. - 9789147084135 ; , s. 401-409
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
3. |
|
|
4. |
- Andersson, Ingemar, 1950-
(författare)
-
Långvarig smärta - en introduktion
- 2010. - 2
-
Ingår i: Smärta och smärtbehandling. - Stockholm : Liber. - 9789147084135 ; , s. 387-400
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
5. |
|
|
6. |
- Edberg, Anna-Karin, 1961-
(författare)
-
Omvårdnad vid kognitiv svikt
- 2011
-
Ingår i: Kognitiv medicin. - Stockholm : Norstedts Förlag. - 9789113023229 ; , s. 418-429
-
Bokkapitel (populärvet., debatt m.m.)
|
|
7. |
|
|
8. |
|
|
9. |
- Marina, N., et al.
(författare)
-
Potential Clinical Application of Angiotensin 2 Receptor Agonists
- 2015
-
Ingår i: The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. - : Elsevier. - 9780128013649 ; , s. 149-153
-
Bokkapitel (refereegranskat)abstract
- In this chapter, we explore the factors influencing the selection of a clinical target for the early clinical development of an AT2 (AT2R) agonist for use in man. We discuss the requirements for an Investigational New Drug application. The only available oral AT2R agonist with an extensive preclinical documentation, outlined in previous chapters, is used as the model for this discussion. The growing body of preclinical data in a wide range of areas relevant to clinical applications justifies human proof of concept clinical studies with compound 21 or other AT2R agonists in several indication areas. © 2015 Elsevier Inc.
|
|
10. |
- Düringer, Caroline, et al.
(författare)
-
HAMLET; a novel tool to identify apoptotic pathways in tumor cells.
- 2005
-
Ingår i: Application of apoptosis to cancer treatment.. - Berlin/Heidelberg : Springer-Verlag. - 9781402033032 ; , s. 223-245
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Tumor cells often carry mutations in genes that control cell survival, and become resistant to signals that trigger cell death. Yet, some cell death pathways remain intact in tumor cells. If identified, these pathways might be exploited to selectively remove tumor cells. HAMLET (human α-lactalbumin made lethal to tumor cells) is a protein-lipid complex derived from human milk that activates cell death programs in tumor cells but not in healthy differentiated cells. We use HAMLET as a tool to identify apoptosis and apoptosis-like cell death mechanisms in tumor cells and to understand if these mechanisms differ between tumor and healthy cells. HAMLET interacts with the cell surface, translocates into the cytoplasm and accumulates in cell nuclei, where it disrupts the chromatin. Recent in vivo studies have shown that HAMLET maintains the tumoricidal activity in glioblastoma, papilloma and bladder cancer models, with no significant side effects. The results suggest that HAMLET should be explored as a new therapeutic agent with selectivity for the tumor and with little toxicity for adjacent healthy tissue. Such therapies are a much-needed complement to conventional treatments, to reduce the side effects and improve the selectivity.
|
|